Production Method 1

2991-42-6

830-43-3

Reaction Conditions

1.1 Reagents: Ammonium hydroxide ;  3 - 4 h, 0 °C

Reference

Unexpected C=N bond formation via NaI-catalyzed oxidative de-tetra-hydrogenative cross-couplings between N,N-dimethyl aniline and sulfamides

Zheng, Yang; et al, RSC Advances, 2015, 5(62), 50113-50117

Production Method 2

1372629-25-8

830-43-3

Reaction Conditions

1.1 Reagents: Trifluoromethanesulfonic acid Solvents: Toluene ;  3 h, 80 °C
1.2 Reagents: Sodium carbonate Solvents: Water ;  rt

Reference

Bronsted Acid Promoted N-Dealkylation of N-Alkyl(sulfon)amides

Gu, Linghui; et al, ChemistrySelect, 2021, 6(33), 8839-8842

Production Method 3

1286478-99-6

830-43-3

Reaction Conditions

1.1 Reagents: Dess-Martin periodinane Solvents: 1,1,1,3,3,3-Hexafluoro-2-propanol ,  Water ;  0.5 h, 40 °C

Reference

Hypervalent organoiodine promoted dearylation reaction of N-aryl sulfonamides

Song, Mengmeng; et al, Youji Huaxue, 2020, 40(8), 2433-2441

Production Method 4

830-43-3

Reaction Conditions

1.1 Reagents: Oxygen Catalysts: Copper oxide (CuO) Solvents: Dimethyl sulfoxide ;  8 h, 100 °C

Reference

Cu(II)-catalyzed decarboxylation/elimination of N-arylsulfonyl amino acids to primary aryl sulfonamides

Zhou, Liandi; et al, Synthetic Communications, 2016, 46(15), 1299-1306

Production Method 5

657-70-5

830-43-3

Reaction Conditions

1.1 Reagents: Sodium nitrite ,  Hydrochloric acid ,  Sulfuric acid ,  Phosphorus oxychloride Solvents: Ethanol ,  Water

Reference

Synthesis and hypoglycemic activity of trifluoromethylated sulfonylureas

Perron, Y. G.; et al, Journal of Medicinal & Pharmaceutical Chemistry, 1961, 4, 41-9

Production Method 6

825-83-2

830-43-3

Reaction Conditions

1.1 Reagents: tert-Butyl hydroperoxide ,  Ammonia ,  Oxygen Catalysts: Iodine Solvents: Acetonitrile ,  Water ;  16 h, rt → 100 °C; 100 °C → rt
1.2 Reagents: Water ;  rt

Reference

A general iodine-mediated synthesis of primary sulfonamides from thiols and aqueous ammonia

Feng, Jian-Bo; et al, Organic & Biomolecular Chemistry, 2016, 14(29), 6951-6954

Production Method 7

14874-70-5

46061-31-8

830-43-3

Reaction Conditions

1.1 Reagents: Triphenylphosphine ,  Sodium pyrosulfite ,  Sodium azide Catalysts: Tetrabutylammonium bromide Solvents: Acetonitrile ,  Water ;  12 h, 80 °C

Reference

Metal-free construction of primary sulfonamides through three diverse salts

Wang, Ming; et al, Green Chemistry, 2018, 20(24), 5469-5473

Production Method 8

455-14-1

830-43-3

Reaction Conditions

1.1 -
2.1 Reagents: Triphenylphosphine ,  Sodium pyrosulfite ,  Sodium azide Catalysts: Tetrabutylammonium bromide Solvents: Acetonitrile ,  Water ;  12 h, 80 °C

Reference

Metal-free construction of primary sulfonamides through three diverse salts

Wang, Ming; et al, Green Chemistry, 2018, 20(24), 5469-5473

Production Method 9

2991-42-6

830-43-3

Reaction Conditions

1.1 Reagents: Ammonium hydroxide Solvents: Water ;  16 h, rt
1.2 Reagents: Hydrochloric acid Solvents: Water ;  < pH 9

Reference

Tetrahydropyridines via FeCl3-Catalyzed Carbonyl-Olefin Metathesis

Rykaczewski, Katie A.; et al, Organic Letters, 2020, 22(7), 2844-2848

Production Method 10

2991-42-6

830-43-3

Reaction Conditions

1.1 Reagents: Ammonia Solvents: Dichloromethane ;  -78 °C

Reference

Identification of the first potent, selective and bioavailable PPARα antagonist

Bravo, Yalda; et al, Bioorganic & Medicinal Chemistry Letters, 2014, 24(10), 2267-2272

Production Method 11

778592-02-2

830-43-3

Reaction Conditions

1.1 Reagents: Periodic acid Solvents: Acetonitrile ;  18 h, rt

Reference

Novel N-dealkylation of N-alkyl sulfonamides and N,N-dialkyl sulfonamides with periodic acid catalyzed by chromium(III) acetate hydroxide

Xu, Liang; et al, Synlett, 2004, (11), 1901-1904

Production Method 12

455-24-3

830-43-3

Reaction Conditions

1.1 Reagents: N-Chlorophthalimide ,  Sulfur dioxide ,  Lithium tetrafluoroborate ,  Pyridinium, 1-fluoro-2,4,6-trimethyl-, tetrafluoroborate(1-) (1:1) Catalysts: Tetrakis(acetonitrile)copper(1+) tetrafluoroborate Solvents: Acetonitrile ;  16 h, 30 - 35 °C
1.2 Reagents: Ammonium hydroxide ,  Diisopropylethylamine Solvents: Water ;  2 - 16 h, rt

Reference

One-Pot Synthesis of Sulfonamides from Unactivated Acids and Amines via Aromatic Decarboxylative Halosulfonylation

Pedersen, P. Scott; et al, Journal of the American Chemical Society, 2023, 145(39), 21189-21196

Production Method 13

128796-45-2

830-43-3

Reaction Conditions

1.1 Reagents: α,α-Diphenyl-N-sulfinylbenzenemethanamine ;  2 h, 160 °C; 160 °C → rt
1.2 Reagents: Cesium carbonate Catalysts: Dichloro[1,2-di(methoxy-κO)ethane]nickel ,  4,4′-Dinonyl-2,2′-bipyridine Solvents: 1,4-Dioxane ;  16 h, 80 °C; 80 °C → rt
1.3 Reagents: Trichloroisocyanuric acid ;  20 min, rt
1.4 Solvents: Water ;  24 h, rt
1.5 Reagents: Methanesulfonic acid ;  rt; 30 min, rt
1.6 Reagents: Sodium bicarbonate Solvents: Water ;  rt

Reference

Nickel(II)-Catalyzed Addition of Aryl and Heteroaryl Boroxines to the Sulfinylamine Reagent TrNSO: The Catalytic Synthesis of Sulfinamides, Sulfonimidamides and Primary Sulfonamides

Lo, Pui Kin Tony ; et al, Journal of the American Chemical Society, 2021, 143(38), 15576-15581

Production Method 14

89520-63-8

830-43-3

Reaction Conditions

1.1 Reagents: Iodine ;  20 min, rt
1.2 Reagents: Ammonia Solvents: Ethanol ,  Water ;  3 h, rt

Reference

Sulfonamide formation from sodium sulfinates and amines or ammonia under metal-free conditions at ambient temperature

Yang, Kai; et al, Green Chemistry, 2015, 17(3), 1395-1399

Production Method 15

2991-42-6

830-43-3

Reaction Conditions

1.1 Solvents: Pyridine ;  1 h, 80 °C
1.2 Reagents: Hydrochloric acid Solvents: Water
2.1 Reagents: Dess-Martin periodinane Solvents: 1,1,1,3,3,3-Hexafluoro-2-propanol ,  Water ;  0.5 h, 40 °C

Reference

Hypervalent organoiodine promoted dearylation reaction of N-aryl sulfonamides

Song, Mengmeng; et al, Youji Huaxue, 2020, 40(8), 2433-2441

Production Method 16

128796-39-4

830-43-3

Reaction Conditions

1.1 1 h, 120 °C
2.1 Reagents: α,α-Diphenyl-N-sulfinylbenzenemethanamine ;  2 h, 160 °C; 160 °C → rt
2.2 Reagents: Cesium carbonate Catalysts: Dichloro[1,2-di(methoxy-κO)ethane]nickel ,  4,4′-Dinonyl-2,2′-bipyridine Solvents: 1,4-Dioxane ;  16 h, 80 °C; 80 °C → rt
2.3 Reagents: Trichloroisocyanuric acid ;  20 min, rt
2.4 Solvents: Water ;  24 h, rt
2.5 Reagents: Methanesulfonic acid ;  rt; 30 min, rt
2.6 Reagents: Sodium bicarbonate Solvents: Water ;  rt

Reference

Nickel(II)-Catalyzed Addition of Aryl and Heteroaryl Boroxines to the Sulfinylamine Reagent TrNSO: The Catalytic Synthesis of Sulfinamides, Sulfonimidamides and Primary Sulfonamides

Lo, Pui Kin Tony ; et al, Journal of the American Chemical Society, 2021, 143(38), 15576-15581

Production Method 17

62-57-7

2991-42-6

830-43-3

Reaction Conditions

1.1 Reagents: Sodium hydroxide Solvents: Water ;  rt
1.2 Reagents: Hydrochloric acid Solvents: Water ;  pH 2 - 3, cooled
2.1 Reagents: Oxygen Catalysts: Copper oxide (CuO) Solvents: Dimethyl sulfoxide ;  8 h, 100 °C

Reference

Cu(II)-catalyzed decarboxylation/elimination of N-arylsulfonyl amino acids to primary aryl sulfonamides

Zhou, Liandi; et al, Synthetic Communications, 2016, 46(15), 1299-1306

4-(trifluoromethyl)benzene-1-sulfonamide Raw materials

• 4-(Trifluoromethyl)benzoic acid
• 4-(trifluoromethyl)benzene-1-thiol
• 2-amino-2-methylpropanoic acid
• Borate(1-),tetrafluoro-
• 4-(Trifluoromethyl)benzenesulfonyl chloride
• [4-(trifluoromethyl)phenyl]boronic acid
• Boroxin, tris[4-(trifluoromethyl)phenyl]-
• 2-amino-4-(trifluoromethyl)benzene-1-sulfonamide
• Benzenesulfonamide, N-(1-methylethyl)-4-(trifluoromethyl)-
• N-(4-Methylphenyl)-4-(trifluoromethyl)benzenesulfonamide
• sodium 4-(Trifluoromethyl)benzene-1-sulfinate
• N-tert-butyl-4-(trifluoromethyl)benzene-1-sulfonamide
• P-trifluoromethylaniline

4-(trifluoromethyl)benzene-1-sulfonamide Preparation Products

• 4-(trifluoromethyl)benzene-1-sulfonamide (830-43-3)

• 1. Excellent kinetics of single-phase Gd-doped ceria fuel electrodes in solid oxide cells?
  Andreas Nenning,Manuel Holzmann,Jürgen Fleig,Alexander K. Opitz Mater. Adv., 2021,2, 5422-5431
• 2. Establishing the accuracy of position-specific carbon isotope analysis of propane by GC-pyrolysis-GC-IRMS
  ChangjieLiu,PengLiu,XiaofengWang,XiaoqiangLi,JuskeHorita
• 3. Excimer and exciplex formation in a pair of bright phosphorescent isomers constructed from Cu3(pyrazolate)3 and Cu3I3 coordination luminophores?
  Shun-Ze Zhan,Mian Li,Xiao-Ping Zhou,Dan Li,Seik Weng Ng RSC Adv., 2011,1, 1457-1459
• 4. Emergence of microfluidic wearable technologies
  Joo Chuan Yeo,Kenry Lab Chip, 2016,16, 4082-4090
• 5. Excimer emission and magnetoluminescence of radical-based zinc(ii) complexes doped in host crystals?
  Shojiro Kimura,Tetsuro Kusamoto Chem. Commun., 2020,56, 11195-11198

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzenesulfonamides
• Pharmaceutical and Biochemical Products Medicinal Building Blocks Fluorine containing Building Blocks

• 672-58-2(3-(trifluoromethyl)benzene-1-sulfonamide)
• 873002-39-2(N-methyl-4-(trifluoromethyl)benzene-1-sulfonamide)
• 950500-72-8(4-[4-(trifluoromethyl)phenyl]benzenesulfonamide)
• 951625-11-9(2,5-Bis(trifluoromethyl)benzenesulfonamide)
• 1869-24-5(2-(Trifluoromethyl)benzenesulfonamide)
• 1630983-00-4(4-(Difluoromethyl)benzene-1-sulfonamide)
• 146533-45-1(2,4-Bis(trifluoromethyl)benzenesulfonamide)
• 1261622-17-6(2-methyl-4-(trifluoromethyl)benzene-1-sulfonamide)
• 1261584-18-2(4-Methyl-2-(trifluoromethyl)benzenesulfonamide)
• 39213-22-4(3,5-bis(Trifluoromethyl)benzene-1-sulfonamide)