Production Method 1

830-03-5

Reaction Conditions

1.1 Catalysts: Silica ;  50 min, rt

Reference

Highly efficient solvent-free acetylation of alcohols with acetic anhydride catalyzed by recyclable sulfonic acid catalyst (SBA-15-Ph-Pr-SO3H) - An environmentally benign method

Zareyee, Daryoush; et al, Canadian Journal of Chemistry, 2012, 90(5), 464-468

Production Method 2

830-03-5

Reaction Conditions

1.1 Catalysts: Silica ,  12-Tungstosilicic acid ;  3 min, 25 °C
1.2 Reagents: Water ;  25 °C

Reference

Acetylation of alcohols and phenols using continuous-flow, tungstosilicic acid-supported, monolith microreactors with scale-up capability

He, Ping; et al, Journal of Flow Chemistry, 2012, 2, 47-51

Production Method 3

830-03-5

Reaction Conditions

1.1 Catalysts: Titania ;  40 min, 25 °C

Reference

TiO2, a simple and an efficient catalyst for esterification of phenols under solvent-free condition

Pasha, Mohamed Afzal; et al, Indian Journal of Chemistry, 2008, (4), 597-600

Production Method 4

830-03-5

Reaction Conditions

1.1 Reagents: Pyridine Solvents: Dichloromethane ;  0 °C → rt; 3 h, rt

Reference

NIS/TBHP Induced Regioselective Selenation of (Hetero)Arenes via Direct C-H Functionalization

Ding, Chaochao; et al, ChemCatChem, 2018, 10(23), 5397-5401

Production Method 5

830-03-5

Reaction Conditions

1.1 Catalysts: Ferric perchlorate Solvents: Acetic acid ;  24 h, rt

Reference

Catalytic acetylation of alcohols and phenols with ferric perchlorate in acetic acid

Heravi, Majid M.; et al, Catalysis Communications, 2006, 7(3), 136-139

Production Method 6

830-03-5

Reaction Conditions

1.1 Catalysts: Cesium hydrogen tetracosa-μ-oxododecaoxo[μ12-[phosphato(3-)-κO:κO:κO:κO′:κO′:κO′… Solvents: Acetonitrile ;  30 min, 50 °C

Reference

Characterization of novel Cs and K substituted phosphotungstic acid modified MCM-41 catalyst and its catalytic activity towards acetylation of aromatic alcohols

Rana, Surjyakanta; et al, Journal of Chemical Sciences (Bangalore, 2012, 124(5), 1117-1125

Production Method 7

1849-36-1

830-03-5

Reaction Conditions

1.1 Catalysts: 1H-1,4-Diazepine, 2,3-dihydro-5,7-dimethyl-, compd. with perchlorate (1:1) ;  rt; 4 h, 40 °C
1.2 Reagents: Sodium bicarbonate Solvents: Water ;  neutralized, cooled

Reference

Diazepinium perchlorate: a neutral catalyst for mild, solvent-free acetylation of carbohydrates and other substances

Giri, Santosh Kumar; et al, RSC Advances, 2017, 7(22), 13653-13667

Production Method 8

155164-63-9

830-03-5

Reaction Conditions

1.1 rt; 5 min, 150 °C; cooled

Reference

Catalyst-free esterification of alcohols using 2-acyl-4,5-dichloropyridazinones under microwave conditions

Kim, Bo Ram; et al, Tetrahedron, 2013, 69(15), 3234-3237

Production Method 9

122-79-2

830-03-5

Reaction Conditions

1.1 Reagents: Ceric ammonium nitrate ;  2 - 4 min, rt; 3 min, heated

Reference

Solid-state regioselective nitration of activated hydroxyaromatics and hydroxycoumarins with cerium(IV) ammonium nitrate

Ganguly, Nemai C.; et al, Journal of Chemical Research, 2005, (11), 733-735

Production Method 10

830-03-5

Reaction Conditions

Reference

Mercuration of diethyl aryl phosphate with mercuric acetate

El-Sawi, E.; et al, Journal of the Indian Chemical Society, 1981, 58(9), 831-5

Production Method 11

104-04-1

830-03-5

Reaction Conditions

1.1 Reagents: Sodium nitrite Solvents: Acetic acid ,  Acetic anhydride
1.2 Reagents: Water

Reference

Conversion of N-Aromatic Amides to O-Aromatic Esters

Glatzhofer, Daniel T.; et al, Organic Letters, 2002, 4(14), 2349-2352

Production Method 12

1014-66-0

830-03-5

Reaction Conditions

1.1 Catalysts: Sulfuric acid (silica-bound) Solvents: Dichloromethane ;  45 min, rt

Reference

An efficient and convenient method for desilylation-acetylation of trimethylsilyl ethers catalyzed by silica sulfuric acid

Jin, Tong-Shou; et al, Asian Journal of Chemistry, 2008, 20(7), 5005-5010

Production Method 13

13483-16-4

830-03-5

Reaction Conditions

1.1 20 min, 80 °C

Reference

Chemoselective acylation of amines, thiols, and phenols using 2,4,6-triacyloxy-1,3,5-triazine (TAT) as a new and effective reagent under mild condition

Gholap, Somnath S.; et al, Journal of the Indian Chemical Society, 2009, 86(2), 179-182

Production Method 14

830-03-5

Reaction Conditions

1.1 Reagents: Pyridine Catalysts: 4-(Dimethylamino)pyridine Solvents: Dichloromethane ;  2 h, rt

Reference

Lens culinaris: A new biocatalyst for reducing carbonyl and nitro groups

Ferreira, Daniele Alves; et al, Biotechnology and Bioprocess Engineering, 2012, 17(2), 407-412

Production Method 15

830-03-5

Reaction Conditions

1.1 Catalysts: Bismuth trichloride Solvents: Acetic acid

Reference

A convenient and chemoselective acetylation and formylation of alcohols and phenols using acetic acid and ethyl formate in the presence of Bi(III) salts

Mohammadpoor-Baltork, Iraj; et al, Journal of Chemical Research, 2001, (7), 280-282

Production Method 16

127-09-3

830-03-5

Reaction Conditions

1.1 Reagents: (Diethylamino)sulfur trifluoride Catalysts: 4-(Dimethylamino)pyridine Solvents: Acetonitrile ;  rt; 6 h, rt

Reference

Acylation of phenols to phenolic esters with organic salts

Zhang, Zhanrong; et al, Green Chemistry, 2022, 24(24), 9763-9771

Production Method 17

155164-63-9

830-03-5

Reaction Conditions

1.1 5 min, rt → 100 °C

Reference

Rapid and ecofriendly esterification of alcohols with 2-acylpyridazinones

Kim, Bo Ram; et al, Bulletin of the Korean Chemical Society, 2013, 34(11), 3410-3414

Production Method 18

155164-63-9

830-03-5

Reaction Conditions

1.1 Catalysts: Aluminum chloride Solvents: Tetrahydrofuran ;  1 min, rt
1.2 5 min, rt
1.3 Reagents: Water ;  10 min, rt

Reference

Facile esterification of alcohols with 2-acyl-4,5-dichloropyridazin-3(2h)-ones under Friedel-Crafts conditions

Kim, Bo Ram; et al, Synlett, 2014, 25(13), 1909-1915

Production Method 19

108-22-5

830-03-5

Reaction Conditions

1.1 Catalysts: Aluminum triflate ;  5 min, rt

Reference

Al(OTf)3 as a highly efficient catalyst for the rapid acetylation of alcohols, phenols, and thiophenols under solvent-free conditions

Kamal, Ahmed; et al, Tetrahedron Letters, 2007, 48(22), 3813-3818

Production Method 20

104-04-1

830-03-5

Reaction Conditions

1.1 Reagents: Sodium nitrite Solvents: Acetic acid ,  Acetic anhydride ;  24 h, 0 °C → rt

Reference

Sodium nitrite

McCullough, Kevin J., e-EROS Encyclopedia of Reagents for Organic Synthesis, 2016, 1, 1-11

Production Method 21

830-03-5

Reaction Conditions

1.1 Reagents: Sodium hydroxide Solvents: Water ;  10 h, 0.3 MPa, 140 °C; 140 °C → rt
1.2 30 min, rt → 80 °C

Reference

An improved synthesis of a β-blocker celiprolol hydrochloride

Ji, Li; et al, Journal of Chemical Research, 2011, 35(11), 640-643

Production Method 22

830-03-5

Reaction Conditions

1.1 Catalysts: Aluminum triflate ;  2 h, rt

Reference

Al(OTf)3 as a highly efficient catalyst for the rapid acetylation of alcohols, phenols, and thiophenols under solvent-free conditions

Kamal, Ahmed; et al, Tetrahedron Letters, 2007, 48(22), 3813-3818

Production Method 23

830-03-5

Reaction Conditions

1.1 Catalysts: Poly(vinylpyrrolidone) ,  Zirconium chloride (ZrCl4) Solvents: Chloroform ,  Hexane ;  1.67 h, reflux

Reference

Polyvinylpyrrolidone-supported zirconium nanoparticles: synthesis, characterization, efficiency as a new polymer nanocomposite catalyst for one-step transesterification reaction

Azadi, Sedigheh; et al, Monatshefte fuer Chemie, 2023, 154(2), 239-248

Production Method 24

20443-91-8

830-03-5

Reaction Conditions

1.1 Reagents: Bismuth nitrate Catalysts: Dabco ;  3 min, heated

Reference

Solvent-free DABCO-catalyzed one-pot conversion of tetrahydropyranyl ethers into acetates by the action of bismuth(III) nitrate under microwave irradiation

Asadolah, K.; et al, Russian Journal of Organic Chemistry, 2009, 45(7), 1110-1111

Production Method 25

62-31-7

830-03-5

Reaction Conditions

1.1 Reagents: Diisopropylcarbodiimide ,  1-Hydroxybenzotriazole Solvents: Dimethylformamide ;  2 h, rt
1.2 Reagents: Potassium carbonate Solvents: Dimethylformamide ;  12 h, rt

Reference

A Magnetic Biomimetic Nanocatalyst for Cleaving Phosphoester and Carboxylic Ester Bonds under Mild Conditions

Zheng, Yan; et al, Organic Letters, 2006, 8(15), 3215-3217

Production Method 26

14874-70-5

830-03-5

Reaction Conditions

Reference

Water-soluble acylating agents: preparation of 2-acylthio-1-alkylpyridinium salts and acylation of phenols, acids, and (or) amines with these salts in an aqueous phase

Sakakibara, Tohru; et al, Bulletin of the Chemical Society of Japan, 1988, 61(1), 247-53

Production Method 27

830-03-5

Reaction Conditions

1.1 Reagents: Potassium carbonate Catalysts: Tris(2,2′-bipyridyl)ruthenium(II) chloride Solvents: Acetonitrile ;  3 - 6 h, rt
1.2 Solvents: Water

Reference

Site-selective phenol acylation mediated by thioacids via visible light photoredox catalysis

Shi, Lili; et al, Organic Chemistry Frontiers, 2018, 5(8), 1312-1319

4-Nitrophenyl acetate Raw materials

• Isopropenyl acetate
• Sodium acetate
• 4'-Nitroacetanilide
• Phenyl acetate
• Triacetyl Cyanurate
• Borate(1-),tetrafluoro-
• 4-nitrobenzene-1-thiol
• Benzene,1-nitro-4-[(trimethylsilyl)oxy]-
• 2H-Pyran, tetrahydro-2-(4-nitrophenoxy)-
• Dopamine hydrochloride
• 3(2H)-Pyridazinone,2-acetyl-4,5-dichloro-

4-Nitrophenyl acetate Preparation Products

• 4-Nitrophenyl acetate (830-03-5)

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• Solvents and Organic Chemicals Organic Compounds Benzenoids Phenol esters Phenol esters
• Solvents and Organic Chemicals Organic Compounds Benzenoids Phenol esters
• Solvents and Organic Chemicals Organic Compounds Acids/Esters

• 1956-06-5(4-Nitrophenyl propionate)
• 17639-39-3(H-Gly-ONp)
• 19786-48-2(Methyl 4-Nitrophenoxyacetate)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)