Cas no 83-48-7 (Stigmasterol)

Stigmasterol is a phytosterol found in various plant sources, including soybeans and calabar beans. It serves as a precursor in the synthesis of steroid hormones, vitamin D3, and other biologically active compounds. Its chemical structure features a double bond at the C22 position, distinguishing it from other sterols like β-sitosterol. Stigmasterol is valued for its role in pharmaceutical and nutraceutical applications, particularly in cholesterol management and anti-inflammatory research. It exhibits potential antioxidant properties and is studied for its effects on lipid metabolism. The compound is typically isolated via solvent extraction or chromatography, ensuring high purity for industrial and research use. Its stability and bioavailability make it a versatile intermediate in organic synthesis.
Stigmasterol structure
Stigmasterol structure
Product Name:Stigmasterol
CAS No:83-48-7
MF:C29H48O
MW:412.690829277039
MDL:MFCD00003630
CID:34296
PubChem ID:24899523
Update Time:2025-11-02

Stigmasterol Chemical and Physical Properties

Names and Identifiers

    • Stigmasterol
    • 3BETA-HYDROXY-24-ETHYL-5,22-CHOLESTADIENE
    • [3B-HYDROXY-24-ETHYL-D] ZZ-CHOLESTADIENE
    • 5,22-STIGMASTADIEN-3-BETA-OL
    • 5,22-CHOLESTADIEN-24B-ETHYL-3BETA-OL
    • 5,22-CHOLESTADIEN-24BETA-ETHYL-3BETA-OL
    • (24S)-5,22-STIGMASTADIEN-3BETA-OL
    • STIGMASTERIN
    • Stigmasta-5,22-dien-3-ol,(3b,22E)-
    • STIGMASTEROL(AS)
    • STIGMASTEROL(P) PrintBack
    • (3β,22E)-StigMasta-5,22-dien-3-ol
    • 22-Dehydro-24-ethylcholesterol
    • 24S-ethylcholest-5,22-dien-3β-ol
    • 3β-Hydroxy-24-ethyl-5,22-cholestadiene
    • 5,22-stigmastadien-3β-ol
    • 5,22-StigMastadiene-3β-ol
    • Anti-stiffness factor
    • isofucosterol
    • PHYTOSTEROL
    • stigmasta-5,22-dien-3β-ol
    • Stigmastero
    • STIGMASTEROL (STIGMASTERIN)
    • STIGMASTEROL(P)
    • SULFISOXAZOLE
    • Stigmasta-5,22-dien-3beta-ol
    • Stigmasta-5
    • [ "Stigmasta-5", "22-dien-3-ol" ]
    • 110801
    • beta-Stigmasterol
    • D5-Stigmasterol
    • Stigmasterin; Phytosterol; beta-Stigmasterol; D5-Stigmasterol; 110801
    • (3β,22E)-Stigmasta-5,22-dien-3-ol (ACI)
    • Stigmasta-5,22-dien-3β-ol (8CI)
    • (24S)-24-Ethylcholesta-5,22-dien-3β-ol
    • (24S)-5,22-Stigmastadien-3β-ol
    • (24S)-Stigmast-5,22-dien-3β-ol
    • 24-Ethyl-5,22-cholestadien-3β-ol
    • 24β-Ethyl-5,22-cholestadien-3β-ol
    • MeSH ID: D013265
    • NSC 8095
    • Stigmasta-5,22(E)-dien-3β-ol
    • β-Stigmasterol
    • Δ5,22-Stigmastadien-3β-ol
    • Δ5-Stigmasterol
    • MDL: MFCD00003630
    • Inchi: 1S/C29H48O/c1-7-21(19(2)3)9-8-20(4)25-12-13-26-24-11-10-22-18-23(30)14-16-28(22,5)27(24)15-17-29(25,26)6/h8-10,19-21,23-27,30H,7,11-18H2,1-6H3/b9-8+/t20-,21-,23+,24+,25-,26+,27+,28+,29-/m1/s1
    • InChI Key: HCXVJBMSMIARIN-PHZDYDNGSA-N
    • SMILES: C[C@@]12[C@@H]([C@H](C)/C=C/[C@@H](CC)C(C)C)CC[C@H]1[C@@H]1CC=C3C[C@H](CC[C@]3(C)[C@H]1CC2)O

Computed Properties

  • Exact Mass: 412.37100
  • Monoisotopic Mass: 412.371
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 1
  • Hydrogen Bond Acceptor Count: 1
  • Heavy Atom Count: 30
  • Rotatable Bond Count: 5
  • Complexity: 674
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 9
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 1
  • Undefined Bond Stereocenter Count: 0
  • Molecular Weight: 412.7
  • Surface Charge: 0
  • XLogP3: 8.6
  • Topological Polar Surface Area: 20.2

Experimental Properties

  • Color/Form: Cryst.
  • Density: 0.9639 (rough estimate)
  • Melting Point: 166.0 to 170.0 deg-C
  • Boiling Point: 490.4°C at 760 mmHg
  • Flash Point: 138
  • Refractive Index: 1.5000 (estimate)
  • Solubility: chloroform: soluble50 mg/ml
  • Water Partition Coefficient: Insoluble
  • PSA: 20.23000
  • LogP: 7.80080
  • Vapor Pressure: 1.62X10-10 mm Hg at 25 °C (est)
  • Merck: 8815
  • Specific Rotation: -50 o (c=2, CHCl3)
  • λmax: 226(MeOH)(lit.)
  • Solubility: Soluble in hot ethanol, ether, acetone, benzene, chloroform and other organic solvents, insoluble in water

Stigmasterol Security Information

Stigmasterol Customs Data

  • HS CODE:2906199090
  • Customs Data:

    China Customs Code:

    2906199090

    Overview:

    2906199090. Other naphthenic alcohols,Cycloenol and cycloterpenol. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:5.5%. general tariff:30.0%

    Declaration elements:

    Product Name, component content, use to

    Summary:

    2906199090. cyclanic, cyclenic or cyclotherpenic alcohols. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%

Stigmasterol Pricemore >>

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Stigmasterol Production Method

Production Method 1

Reaction Conditions
1.1 Reagents: Sodium hydride Solvents: Hexamethylphosphoramide
Reference
Reductive cleavage of tert-butyldimethylsilyl ethers with sodium hydride
Shekhani, Mohammed Saleh; et al, Tetrahedron Letters, 1988, 29(47), 6161-2

Production Method 2

Reaction Conditions
1.1 Catalysts: Azobisisobutyronitrile ,  Pentafluorobenzenethiol Solvents: Chlorobenzene ;  rt → 80 °C; 3 h, 80 °C
Reference
Thiol catalyzed aerobic debenzylation of alcohols and amines
Lardy, Samuel W.; et al, ChemRxiv, 2021, 1, 1-12

Production Method 3

Reaction Conditions
1.1 Reagents: Hydrochloric acid Solvents: Methanol ;  overnight, rt
Reference
Two new steroids dehydroadynerizoside and neristigmol from Nerium oleander leaves
Siddiqui, B. S.; et al, Polish Journal of Chemistry, 2006, 80(3), 445-452

Production Method 4

Reaction Conditions
1.1 Reagents: Sodium bicarbonate Solvents: Methyl ethyl ketone ,  Water
Reference
Synthesis of brassinolide. Part II. A simple synthesis of steroidal 3α,5-cyclo-6-ones and their efficient transformation to steroidal 2-en-6-ones
Aburatani, Masakazu; et al, Synthesis, 1987, (2), 181-3

Production Method 5

Reaction Conditions
1.1 Reagents: Hydrochloric acid Solvents: Water ;  2 h, reflux
Reference
A New 3,4-seco-Lupane Derivative from Lasianthus gardneri
Dallavalle, Sabrina; et al, Journal of Natural Products, 2004, 67(5), 911-913

Production Method 6

Reaction Conditions
1.1 Catalysts: Dibutyltin oxide Solvents: Methanol ,  Chloroform ;  6 h, 50 °C
Reference
Mild and selective deprotection method of acetylated steroids and diterpenes by dibutyltin oxide
Wang, Shao-Min; et al, Steroids, 2007, 72(1), 26-30

Production Method 7

Reaction Conditions
1.1 Reagents: Potassium bicarbonate Solvents: Acetone ,  Water ;  6 h, reflux
Reference
Improvement of synthetic method of Brassinosteroids
Ruensamran, Wanwikar; et al, Kamphaengsaen International Natural Products Symposium: The Relationship between Living Organisms and Environment, 2010, 208, 208-215

Production Method 8

Reaction Conditions
1.1 Reagents: Potassium tert-butoxide Catalysts: 2982793-44-0 ;  48 h, 120 °C
Reference
Triazole backbone ligand in an unprecedented efficient manganese catalyst for use in transfer hydrogenation
Liang, Qianqian; et al, Science China: Chemistry, 2023, 66(7), 2028-2036

Production Method 9

Reaction Conditions
1.1 Reagents: Triethylamine Solvents: Methyl ethyl ketone
2.1 Reagents: Sodium bicarbonate Solvents: Methyl ethyl ketone ,  Water
Reference
Synthesis of brassinolide. Part II. A simple synthesis of steroidal 3α,5-cyclo-6-ones and their efficient transformation to steroidal 2-en-6-ones
Aburatani, Masakazu; et al, Synthesis, 1987, (2), 181-3

Stigmasterol Raw materials

Stigmasterol Preparation Products

Stigmasterol Suppliers

Tiancheng Chemical (Jiangsu) Co., Ltd
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(CAS:83-48-7)Stigmasterol
Order Number:LE10415;LE957
Stock Status:in Stock
Quantity:25KG,200KG,1000KG
Purity:99%
Pricing Information Last Updated:Friday, 20 June 2025 12:03
Price ($):discuss personally
Amadis Chemical Company Limited
Gold Member
Audited Supplier Audited Supplier
(CAS:83-48-7)Stigmasterol
Order Number:A840582
Stock Status:in Stock
Quantity:500g/100g/25g
Purity:99%
Pricing Information Last Updated:Friday, 30 August 2024 06:50
Price ($):294.0/501.0/201.0

Stigmasterol Spectrogram

1H NMR 300 MHz DMSO
1H NMR
13C NMR
13C NMR

Additional information on Stigmasterol

Stigmasterol (CAS No. 83-48-7): A Comprehensive Guide to Its Properties, Applications, and Market Trends

Stigmasterol (CAS No. 83-48-7) is a plant-derived phytosterol that has garnered significant attention in recent years due to its versatile applications in pharmaceuticals, nutraceuticals, and cosmetics. As a natural sterol, it shares structural similarities with cholesterol but offers unique bioactive properties. This article delves into the molecular characteristics, health benefits, industrial uses, and emerging market trends of stigmasterol, addressing common queries like "stigmasterol benefits" and "stigmasterol vs beta-sitosterol."

Chemically classified as Δ5,22-stigmastadien-3β-ol, stigmasterol is a white crystalline powder with the molecular formula C29H48O. Its CAS number 83-48-7 serves as a unique identifier in chemical databases. The compound is predominantly extracted from soybean oil, calabar bean, or other plant sources, making it a sought-after ingredient in vegan supplements and plant-based formulations. Researchers have identified its potential in modulating lipid metabolism, which aligns with trending searches such as "natural cholesterol-lowering agents" and "plant sterols for heart health."

The pharmacological profile of stigmasterol reveals anti-inflammatory, antioxidant, and immunomodulatory effects. Recent studies highlight its role in hormone synthesis, particularly as a precursor for progesterone in the pharmaceutical industry. This connects to popular inquiries like "stigmasterol for hormonal balance" and "sterols in skincare." In cosmetic formulations, its ability to reinforce skin barrier function has made it a key component in anti-aging creams and eczema treatments, responding to the growing demand for clean beauty ingredients.

Industrial applications of CAS 83-48-7 extend to food fortification, where it's used as a nutraceutical additive in functional foods targeting cardiovascular health. Market analysts note a 12% annual growth in the phytosterol market, driven by consumer interest in "plant-derived wellness solutions." The compound's GRAS (Generally Recognized As Safe) status by FDA further bolsters its adoption in dietary supplements addressing queries like "is stigmasterol safe" and "stigmasterol dosage recommendations."

Emerging research explores stigmasterol's potential in neuroprotective therapies, with preclinical studies suggesting benefits in neurodegenerative conditions. This aligns with trending health topics such as "natural nootropics" and "plant compounds for brain health." The compound's apoptosis-inducing properties in certain cell lines have also sparked interest in oncological research, though this remains an area of active investigation.

From a commercial perspective, stigmasterol production has adapted to sustainability trends, with manufacturers implementing green extraction technologies to meet demand for eco-friendly phytochemicals. Analytical techniques like HPLC and GC-MS ensure the purity of CAS 83-48-7 products, a critical factor for pharmaceutical-grade applications. The global market is projected to reach USD 420 million by 2027, fueled by increasing awareness of plant-based therapeutics and answers to searches like "where to buy high-purity stigmasterol."

Quality standards for stigmasterol vary by application, with USP-grade material required for medicinal use and food-grade specifications for nutraceuticals. Regulatory frameworks in major markets address purity concerns reflected in queries such as "stigmasterol side effects" and "stigmasterol drug interactions." The compound's stability profile allows for versatile formulation in tablets, softgels, and topical preparations, making it adaptable to diverse product development needs.

Future directions for stigmasterol research include exploring its synergistic effects with other bioactive compounds and developing novel delivery systems to enhance bioavailability. These advancements respond to industry demands for next-generation nutraceuticals and more effective natural therapeutic agents. As consumer preference shifts toward plant-based solutions, stigmasterol (CAS No. 83-48-7) stands poised to play an increasingly prominent role in health and wellness formulations worldwide.

Recommended suppliers
Tiancheng Chemical (Jiangsu) Co., Ltd
(CAS:83-48-7)Stigmasterol
LE10415;LE957
Purity:99%/99%
Quantity:25KG,200KG,1000KG/25KG,200KG,1000KG
Price ($):Inquiry/Inquiry
Email
Amadis Chemical Company Limited
(CAS:83-48-7)Stigmasterol
A840582
Purity:99%/99%/99%
Quantity:500g/100g/25g
Price ($):294.0/501.0/201.0
Email