Production Method 1

586-77-6

829-02-7

Reaction Conditions

1.1 Reagents: Sodium nitrite Solvents: Acetic acid ,  Water ;  10 min, rt; overnight, rt

Reference

Synthesis of functionalized macrocyclic compounds as Na+ and K+ receptors: a mild and high yielding nitration in water of mono and bis 2-methoxyaniline functionalized crown ethers

Gunnlaugsson, Thorfinnur; et al, Journal of the Chemical Society, 2002, (17), 1954-1962

Production Method 2

594-70-7

829-02-7

Reaction Conditions

1.1 Reagents: Copper bromide (CuBr2) Solvents: Acetonitrile

Reference

Alkyl nitrite-metal halide deamination reactions. 7. Synthetic coupling of electrophilic bromination with substitutive deamination for selective synthesis of multiply brominated aromatic compounds from arylamines

Doyle, Michael P.; et al, Journal of Organic Chemistry, 1980, 45(13), 2570-5

Production Method 3

586-77-6

829-02-7

937-23-5

Reaction Conditions

1.1 Reagents: tert-Butyl nitrite ,  Oxygen Solvents: tert-Butanol ;  9 h, 60 °C

Reference

Solvent-controlled chemoselective N-dealkylation-N-nitrosation or C-nitration of N-alkyl anilines with tert-butyl nitrite

Guo, Xuanhua; et al, Organic Chemistry Frontiers, 2019, 6(19), 3401-3407

Production Method 4

586-77-6

829-02-7

937-23-5

Reaction Conditions

1.1 Reagents: tert-Butyl nitrite ,  Oxygen Solvents: Water ;  4 h, rt

Reference

Solvent-controlled chemoselective N-dealkylation-N-nitrosation or C-nitration of N-alkyl anilines with tert-butyl nitrite

Guo, Xuanhua; et al, Organic Chemistry Frontiers, 2019, 6(19), 3401-3407

Production Method 5

586-77-6

829-02-7

937-23-5

64230-27-9

Reaction Conditions

1.1 Reagents: Trichloroacetic acid ,  Sodium nitrite Solvents: Chloroform

Reference

Aromatic tertiary amines and butyl nitrite

Verardo, Giancarlo; et al, Tetrahedron, 1990, 46(12), 4303-32

Production Method 6

586-77-6

829-02-7

Reaction Conditions

1.1 Reagents: Triphenylphosphine ,  Bromine ,  Silver nitrate Solvents: Acetonitrile ;  rt; 5 min, rt

Reference

Highly chemoselective nitration of aromatic amines using the Ph3P/Br2/AgNO3 system

Iranpoor, Nasser; et al, Tetrahedron Letters, 2006, 47(38), 6879-6881

Production Method 7

3460-18-2

829-02-7

Reaction Conditions

1.1 Reagents: Cesium fluoride Solvents: Dimethylformamide

Reference

Some unexpected products from attempted halogen exchange in 2-nitrohaloaromatic systems

Morgan, S. E.; et al, Tetrahedron Letters, 1978, (48), 4837-8

Production Method 8

586-77-6

829-02-7

937-23-5

Reaction Conditions

1.1 Reagents: tert-Butyl nitrite Catalysts: Tempo Solvents: Acetonitrile ;  0.5 h, rt

Reference

Highly selective sp3 C-N bond activation of tertiary anilines modulated by steric and thermodynamic factors

Jia, Xiaodong; et al, Green Chemistry, 2017, 19(23), 5568-5574

N,N-Dimethyl 4-bromo-2-nitroaniline Raw materials

• 4-Bromo-N,N-dimethylaniline
• 1,4-Dibromo-2-nitrobenzene
• 2-Methyl-2-nitropropane

N,N-Dimethyl 4-bromo-2-nitroaniline Preparation Products

• N,N-Dimethyl 4-bromo-2-nitroaniline (829-02-7)
• Benzenamine,4-bromo-N-methyl-N-nitroso- (937-23-5)
• Benzenamine, 2,4-dibromo-N,N-dimethyl- (64230-27-9)

• 1. Enantio- & chemo-selective preparation of enantiomerically enriched aliphatic nitro alcohols using Candida parapsilosis ATCC 7330
  Sowmyalakshmi Venkataraman RSC Adv., 2015,5, 73807-73813
• 2. Empowering microfluidics by micro-3D printing and solution-based mineral coating?
  Hongxia Li,Aikifa Raza,Qiaoyu Ge,Jin-You Lu,TieJun Zhang Soft Matter, 2020,16, 6841-6849
• 3. Emerging 2D hybrid nanomaterials: towards enhanced sensitive and selective conductometric gas sensors at room temperature
  Hanie Hashtroudi,Ian D. R. Mackinnon J. Mater. Chem. C, 2020,8, 13108-13126
• 4. Embedding heteroatoms: an effective approach to create porphyrin-based functional materials
  Norihito Fukui,Keisuke Fujimoto,Hideki Yorimitsu,Atsuhiro Osuka Dalton Trans., 2017,46, 13322-13341
• 5. Emerging investigator series: first-principles and thermodynamics comparison of compositionally-tuned delafossites: cation release from the (001) surface of complex metal oxides?
  Joseph W. Bennett,Diamond T. Jones,Blake G. Hudson,Joshua Melendez-Rivera,Robert J. Hamers,Sara E. Mason Environ. Sci.: Nano, 2020,7, 1642-1651

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Nitrobenzenes
• Solvents and Organic Chemicals Organic Compounds Amines/Sulfonamides

• 302800-13-1(5-Bromo-N-methyl-2-nitroaniline)
• 918948-27-3(1-Naphthalenamine, 4-bromo-2-nitro-N-phenyl-)
• 863604-71-1(5-Bromo-N-isopropyl-2-nitroaniline)
• 683274-50-2(N-Isopropyl 4-bromo-2-nitroaniline)
• 875-51-4(4-Bromo-2-nitroaniline)
• 6311-47-3(5-Bromo-2-nitro-n-phenylaniline)
• 53484-26-7(4-Bromo-n-methyl-2-nitroaniline)
• 4603-74-1(N-(4-bromophenyl)-2,4-dinitroaniline)
• 610-38-8(4-Bromo-1,2-dinitrobenzene)
• 56136-82-4(4-Bromo-N-ethyl-2-nitroaniline)