Cas no 827-25-8 (2-Bromo-4-chloro-6-nitrophenylamine)

2-Bromo-4-chloro-6-nitrophenylamine is a halogenated nitroaniline derivative primarily used as an intermediate in organic synthesis. Its distinct substitution pattern—bromo, chloro, and nitro groups on the phenylamine scaffold—makes it a versatile building block for pharmaceuticals, agrochemicals, and specialty dyes. The electron-withdrawing nitro group enhances reactivity in nucleophilic aromatic substitution, while the halogen substituents provide sites for further functionalization. This compound exhibits high purity and stability under standard storage conditions, ensuring reliable performance in multi-step synthetic routes. Its well-defined structure allows precise control in the synthesis of complex heterocycles and fine chemicals, making it valuable for research and industrial applications.
2-Bromo-4-chloro-6-nitrophenylamine structure
827-25-8 structure
Product Name:2-Bromo-4-chloro-6-nitrophenylamine
CAS No:827-25-8
MF:C6H4BrClN2O2
MW:251.465159416199
MDL:MFCD08275709
CID:83112
PubChem ID:11064884
Update Time:2025-05-19

2-Bromo-4-chloro-6-nitrophenylamine Chemical and Physical Properties

Names and Identifiers

    • 2-Bromo-4-chloro-6-nitrophenylamine
    • 2-Bromo-4-chloro-6-nitroaniline
    • 2-Bromo-4-chloro-6-nitrobenzenamine (ACI)
    • Aniline, 2-bromo-4-chloro-6-nitro- (6CI, 8CI)
    • AC-1573
    • FT-0633003
    • AKOS005354317
    • NPCIWMOFULRTDX-UHFFFAOYSA-N
    • SY064514
    • 827-25-8
    • AM62110
    • DS-0215
    • 2-bromo-4-chloro-6-nitro-aniline
    • 6-bromo-4-chloro-2-nitroaniline
    • PS-5873
    • DTXSID90453945
    • CS-0096783
    • 2-Bromo-4-chloro-6-nitro-phenylamine
    • SCHEMBL202693
    • A19781
    • A19725
    • MFCD08275709
    • Benzenamine, 2-bromo-4-chloro-6-nitro-
    • (2-bromo-4-chloro-6-nitro-phenyl)-amine
    • EN300-187004
    • 2-Bromo-4-chloro-6-nitrobenzenamine
    • STL495528
    • DB-001471
    • BBL035990
    • MDL： MFCD08275709
    • Inchi： 1S/C6H4BrClN2O2/c7-4-1-3(8)2-5(6(4)9)10(11)12/h1-2H,9H2
    • InChI Key： NPCIWMOFULRTDX-UHFFFAOYSA-N
    • SMILES： [O-][N+](C1C(N)=C(Br)C=C(Cl)C=1)=O

Computed Properties

  • Exact Mass: 249.91400
  • Monoisotopic Mass: 249.91447g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 1
  • Hydrogen Bond Acceptor Count: 1
  • Heavy Atom Count: 12
  • Rotatable Bond Count: 1
  • Complexity: 187
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: 2.9
  • Topological Polar Surface Area: 71.8?2

Experimental Properties

  • Density: 1.909±0.06 g/cm3 (20 oC 760 Torr),
  • Melting Point: 106 oC
  • Boiling Point: 329.275°C at 760 mmHg
  • Flash Point: 152.94°C
  • Refractive Index: 1.677
  • Solubility: Almost insoluble (0.04 g/l) (25 o C),
  • PSA: 71.84000
  • LogP: 3.69730

2-Bromo-4-chloro-6-nitrophenylamine Security Information

2-Bromo-4-chloro-6-nitrophenylamine Customs Data

  • HS CODE：2921420090
  • Customs Data：

    China Customs Code:

    2921420090

    Overview:

    2921420090 Other aniline derivatives and their salts. VAT:17.0% Tax refund rate:9.0% Regulatory conditions:nothing MFN tariff:6.5% general tariff:30.0%

    Declaration elements:

    Product Name, component content, use to

    Summary:

    HS:2921420090 aniline derivatives and their salts VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

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2-Bromo-4-chloro-6-nitrophenylamine Suppliers

Tiancheng Chemical (Jiangsu) Co., Ltd
Gold Member
Audited Supplier Audited Supplier
(CAS:827-25-8)2-溴-4-氯-6-硝基苯胺
Order Number:LE1639699;LE179
Stock Status:in Stock
Quantity:25KG,200KG,1000KG
Purity:99%
Pricing Information Last Updated:Friday, 20 June 2025 12:30
Price ($):discuss personally
Suzhou Senfeida Chemical Co., Ltd
Gold Member
Audited Supplier Audited Supplier
(CAS:827-25-8)2-BROMO-4-CHLORO-6-N
Order Number:1639699
Stock Status:in Stock
Quantity:Company Customization
Purity:98%
Pricing Information Last Updated:Monday, 14 April 2025 21:49
Price ($):discuss personally

2-Bromo-4-chloro-6-nitrophenylamine Related Literature

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Additional information on 2-Bromo-4-chloro-6-nitrophenylamine

Introduction to 2-Bromo-4-Chloro-6-Nitrophenylamine (CAS No. 827-25-8)

2-Bromo-4-chloro-6-nitrophenylamine (CAS No. 827-25-8) is a highly specialized aromatic amine compound with significant applications in various fields of chemistry, particularly in pharmaceuticals, agrochemicals, and advanced materials synthesis. This compound is characterized by its unique structure, which includes a phenyl ring substituted with bromine, chlorine, and nitro groups at the 2-, 4-, and 6-positions, respectively. The presence of these substituents imparts distinctive electronic and steric properties to the molecule, making it a valuable intermediate in the synthesis of complex organic compounds.

The chemical structure of 2-bromo-4-chloro-6-nitrophenylamine is highly symmetrical, with the nitro group (-NO?) exerting strong electron-withdrawing effects, while the bromine and chlorine atoms contribute to both electron-withdrawing and steric effects. This combination of functional groups makes the compound highly reactive under specific conditions, enabling its use in a wide range of organic reactions such as nucleophilic substitutions, electrophilic aromatic substitutions, and coupling reactions.

Recent advancements in synthetic methodologies have significantly enhanced the production efficiency and purity of 2-bromo-4-chloro-6-nitrophenylamine. For instance, researchers have developed novel catalytic systems that facilitate the selective substitution of halogen atoms on aromatic rings without affecting other functional groups. These innovations have not only improved the yield of the compound but also reduced the environmental footprint associated with its synthesis.

In terms of applications, 2-bromo-4-chloro-6-nitrophenylamine has found extensive use in the development of antimicrobial agents, herbicides, and dyes. Its ability to undergo multiple types of chemical transformations makes it an ideal building block for constructing complex molecular architectures. For example, in pharmaceutical chemistry, this compound serves as a key intermediate in the synthesis of novel antibiotics and anticancer drugs.

Moreover, 2-bromo-4-chloro-6-nitrophenylamine has gained attention in materials science due to its potential as a precursor for advanced polymers and nanomaterials. Recent studies have demonstrated that derivatives of this compound can be used to create high-performance polymers with tailored electronic properties, making them suitable for applications in electronics and optoelectronics.

The synthesis of 2-bromo-4-chloro-6-nitrophenylamine typically involves multi-step processes that require precise control over reaction conditions. A common approach involves the nitration of an amino-substituted bromochlorobenzene derivative followed by further functionalization to introduce additional substituents. The optimization of these steps has been a focus of recent research efforts, leading to more efficient and scalable production methods.

In conclusion, 2-bromo-4-chloro-6-nitrophenylamine (CAS No. 827-25-8) is a versatile compound with a wide range of applications across various chemical disciplines. Its unique structure and reactivity make it an invaluable tool for researchers and industry professionals alike. As ongoing research continues to uncover new synthetic pathways and applications for this compound, its significance in modern chemistry is expected to grow further.

827-25-8 (2-Bromo-4-chloro-6-nitrophenylamine) Related Products

Recommended suppliers
Tiancheng Chemical (Jiangsu) Co., Ltd
(CAS:827-25-8)2-溴-4-氯-6-硝基苯胺
LE1639699;LE179
Purity:99%/99%
Quantity:25KG,200KG,1000KG/25KG,200KG,1000KG
Price ($):Inquiry/Inquiry
Email
Suzhou Senfeida Chemical Co., Ltd
(CAS:827-25-8)2-BROMO-4-CHLORO-6-N
1639699
Purity:98%
Quantity:Company Customization
Price ($):Inquiry
Email