Production Method 1

874-90-8

82504-06-1

Reaction Conditions

1.1 Reagents: N-Iodosuccinimide Catalysts: [1,1,1-Trifluoro-N-[(trifluoromethyl)sulfonyl]methanesulfonamidato-κN](triphenyl… Solvents: Dichloromethane ,  Toluene ;  14 h, 85 °C

Reference

Gold(I)-catalyzed iodination of arenes

Leboeuf, David; et al, Synlett, 2014, 25(3), 399-402

Production Method 2

2296-23-3

82504-06-1

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Dimethylformamide ;  3 h, rt

Reference

Pd-catalyzed cross-electrophile Coupling/C-H alkylation reaction enabled by a mediator generated via C(sp3)-H activation

Wu, Zhuo; et al, Chemical Science, 2021, 12(24), 8531-8536

Production Method 3

2296-23-3

82504-06-1

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Dimethylformamide ;  3 h, rt

Reference

Pd-Catalyzed ipso,meta-Dimethylation of ortho-Substituted Iodoarenes via a Base-Controlled C-H Activation Cascade with Dimethyl Carbonate as the Methyl Source

Wu, Zhuo; et al, Journal of the American Chemical Society, 2021, 143(12), 4524-4530

Production Method 4

767-00-0

82504-06-1

Reaction Conditions

1.1 Reagents: Ammonium hydroxide ,  Iodine ,  Potassium iodide Solvents: Water ;  20 h, rt
2.1 Reagents: Potassium carbonate Solvents: Acetone ;  90 min, rt → 70 °C

Reference

Direct Cu-mediated aromatic 18F-labeling of highly reactive tetrazines for pretargeted bioorthogonal PET imaging

Garcia-Vazquez, Rocio; et al, Chemical Science, 2021, 12(35), 11668-11675

Production Method 5

5399-03-1

82504-06-1

10496-75-0

Reaction Conditions

1.1 Solvents: Acetonitrile-d3 ,  Water-d2 ;  35 °C

Reference

The Element Effect in Nucleophilic Aromatic Photosubstitution (SN2Ar*)

Wubbels, Gene G.; et al, Organic Letters, 2007, 9(15), 2803-2806

Production Method 6

874-90-8

82504-06-1

Reaction Conditions

1.1 Reagents: 1,3-Diiodo-5,5-dimethyl-2,4-imidazolidinedione Catalysts: S8 Solvents: Acetonitrile ;  24 h, rt

Reference

Elemental Sulfur-mediated Aromatic Halogenation

Matsuoka, Junpei; et al, Journal of Organic Chemistry, 2024, 89(1), 770-777

Production Method 7

2296-23-3

82504-06-1

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Acetone ;  90 min, rt → 70 °C

Reference

Direct Cu-mediated aromatic 18F-labeling of highly reactive tetrazines for pretargeted bioorthogonal PET imaging

Garcia-Vazquez, Rocio; et al, Chemical Science, 2021, 12(35), 11668-11675

Production Method 8

7188-38-7

529-28-2

82504-06-1

Reaction Conditions

1.1 Reagents: Trifluoromethanesulfonic anhydride ,  Phenoxathiin S-oxide Solvents: Dichloromethane ;  -78 °C; 15 min, -78 °C; -78 °C → rt; 1 h, rt
1.2 Reagents: Sodium acetate Catalysts: Tris(4-bromophenyl)amine ;  15 min, 30 °C
1.3 Solvents: Dimethyl sulfoxide ;  20 h, 60 °C
1.4 Solvents: Water

Reference

A general arene C-H functionalization strategy via electron donor-acceptor complex photoactivation

Dewanji, Abhishek; et al, Nature Chemistry, 2023, 15(1), 43-52

Production Method 9

7188-38-7

529-28-2

82504-06-1

Reaction Conditions

1.1 Reagents: Trifluoromethanesulfonic anhydride ,  Phenoxathiin S-oxide Solvents: Dichloromethane ;  -78 °C; 15 min, -78 °C; -78 °C → rt; 1 h, rt
1.2 Reagents: Sodium acetate Catalysts: Tris(4-bromophenyl)amine Solvents: Dimethyl sulfoxide ;  20 h, 60 °C
1.3 Reagents: Water

Reference

A general arene C-H functionalization strategy via electron donor-acceptor complex photoactivation

Dewanji, Abhishek; et al, ChemRxiv, 2021, 1, 1-9

Production Method 10

767-00-0

82504-06-1

Reaction Conditions

1.1 Reagents: Ammonium hydroxide ,  Iodine Solvents: Methanol ,  Water ;  rt; 3 h, rt
1.2 Reagents: Sodium thiosulfate Solvents: Water ;  rt
1.3 Reagents: Hydrochloric acid Solvents: Water ;  < pH 2
2.1 Reagents: Potassium carbonate Solvents: Dimethylformamide ;  3 h, rt

Reference

Pd-Catalyzed ipso,meta-Dimethylation of ortho-Substituted Iodoarenes via a Base-Controlled C-H Activation Cascade with Dimethyl Carbonate as the Methyl Source

Wu, Zhuo; et al, Journal of the American Chemical Society, 2021, 143(12), 4524-4530

Production Method 11

767-00-0

82504-06-1

Reaction Conditions

1.1 Reagents: Ammonium hydroxide ,  Iodine Solvents: Methanol ;  rt; 3 h, rt
1.2 Reagents: Sodium thiosulfate Solvents: Water
1.3 Reagents: Hydrochloric acid Solvents: Water ;  < pH 2
2.1 Reagents: Potassium carbonate Solvents: Dimethylformamide ;  3 h, rt

Reference

Pd-catalyzed cross-electrophile Coupling/C-H alkylation reaction enabled by a mediator generated via C(sp3)-H activation

Wu, Zhuo; et al, Chemical Science, 2021, 12(24), 8531-8536

3-Iodo-4-methoxybenzonitrile Raw materials

• 4-Methoxybenzonitrile
• 2-Iodo-4-nitroanisole
• Tert-BUTYL ISOCYANIDE
• 2-Iodoanisole
• 4-Hydroxybenzonitrile
• 4-hydroxy-3-iodobenzonitrile

3-Iodo-4-methoxybenzonitrile Preparation Products

• 3-Iodo-4-methoxybenzonitrile (82504-06-1)
• 2-Methoxy-5-nitrobenzonitrile (10496-75-0)

• 1. An integrated droplet-digital microfluidic system for on-demand droplet creation, mixing, incubation, and sorting?
  Lab Chip, 2019,19, 524-535
• 2. An integrated microfluidic platform for sensitive and rapid detection of biological toxins?
  Robert J. Meagher,Anson V. Hatch,Ronald F. Renzi,Anup K. Singh Lab Chip, 2008,8, 2046-2053
• 3. An amide probe as a selective Al3+ and Fe3+ sensor inside the HeLa and a549 cell lines: Pictet–Spengler reaction for the rapid detection of tryptophan amino acid?
  Bidyut Kumar Kundu,Rinky Singh,Ritudhwaj Tiwari,Debasis Nayak New J. Chem., 2019,43, 4867-4877
• 4. An approach to the structure and vibrational analysis of cis- and trans-3-chlorostyrene through IR/Raman and INS spectroscopies and theoretical ab initio/DFT calculations?
  J. M. Granadino-Roldán,M. Fernández-Gómez,A. Navarro,T. Pe?a Ruiz,U. A. Jayasooriya Phys. Chem. Chem. Phys., 2004,6, 1133-1143
• 5. An amorphous carbon nitride/NiO/CoN-based composite: a highly efficient nonprecious electrode for supercapacitors and the oxygen evolution reaction?
  Huifang Yang,Haoran Guo,Peidong Fan,Xinpan Li,Wenlu Ren,Rui Song Nanoscale, 2020,12, 7024-7034

• 2961-62-8(Benzonitrile,4-hydroxy-3,5-diiodo-, sodium salt (1:1))
• 1689-83-4(3,5-Diiodo-4-hydroxybenzonitrile)
• 652997-59-6(Benzonitrile, 4-iodo-3-(phenylmethoxy)-)
• 652997-56-3(Benzonitrile, 4-iodo-3-methoxy-)
• 50597-88-1(3-Iodo-4-methoxytoluene)
• 834907-45-8(4-Hydroxy-3-iodo-5-methoxybenzonitrile)
• 2296-23-3(4-hydroxy-3-iodobenzonitrile)
• 3336-40-1(Benzonitrile,3,5-diiodo-4-methoxy-)
• 103604-48-4(1-Naphthalenecarbonitrile,5-iodo-6-methoxy-)
• 50381-90-3(&nbsp;)