Production Method 1

98-67-9

825-90-1

Reaction Conditions

1.1 Reagents: Sodium hydroxide Solvents: Ethanol ,  Water ;  heated

Reference

Preparation and Characterization of Transparent Polycarbonate with High Flame Retardancy and Smoke Suppression

Wang, Bingtao; et al, ACS Applied Polymer Materials, 2023, 5(8), 6463-6471

Production Method 2

98-67-9

636-78-2

825-90-1

36747-37-2

Reaction Conditions

1.1 Reagents: Sodium hydroxide Solvents: Water ;  pH 7 - 8

Reference

Synthesis and application of amino-carboxylic based high performance superplasticizer for concrete

Xu, Chen, Asian Journal of Chemistry, 2014, 26(17), 5393-5395

Production Method 3

65-85-0

825-90-1

36747-37-2

Reaction Conditions

1.1 Reagents: Sulfuric acid ;  2 h, 85 °C
2.1 Reagents: Sodium hydroxide Solvents: Water ;  pH 7 - 8

Reference

Synthesis and application of amino-carboxylic based high performance superplasticizer for concrete

Xu, Chen, Asian Journal of Chemistry, 2014, 26(17), 5393-5395

Production Method 4

825-90-1

Reaction Conditions

1.1 2 h, 45 °C
1.2 -
1.3 Reagents: Hydrogen Catalysts: (SP-4-2)-Chlorotris(triphenylphosphine)rhodium Solvents: Dichloromethane ,  1,4-Dioxane ;  115 bar, rt
1.4 Reagents: Potassium carbonate Solvents: Toluene ,  Dimethylacetamide ;  9 h, 120 °C

Reference

Electrochemical performance of membranes based on hydrogenated polynorbornenes functionalized with imide side groups containing sulfonated fluorinated moieties

Santiago, Arlette A.; et al, Journal of Membrane Science, 2012, 403, 403-404

4-Hydroxybenzenesulfonic Acid Sodium Salt Raw materials

• Benzoic acid
• 4-Hydroxybenzenesulfonic acid
• 4-Sulfobenzoic acid

4-Hydroxybenzenesulfonic Acid Sodium Salt Preparation Products

• Benzoic acid, 4-sulfo-,sodium salt (1:?) (36747-37-2)
• 4-Hydroxybenzenesulfonic Acid Sodium Salt (825-90-1)

• 1. An apparatus for determining small amounts of alchohol in sour milk and urine
  Analyst, 1964,89, 272-275
• 2. An integrated cathode and solid electrolyte via in situ polymerization with significantly reduced interface resistance?
  Jialiang Yuan,Ran Dong,Yuan Li,Yang Liu,Zhuo Zheng,Yuxia Liu,Yan Sun,Benhe Zhong,Zhenguo Wu,Xiaodong Guo Chem. Commun., 2021,57, 13004-13007
• 3. An atlas of endohedral Sc2S cluster fullerenes?
  Li-Hua Gan,Rui Wu,Jian-Lei Tian,Patrick W. Fowler Phys. Chem. Chem. Phys., 2017,19, 419-425
• 4. An approach to C–N activation: coupling of arenesulfonyl hydrazides and arenesulfonyl chlorides with tert-amines via a metal-, oxidant- and halogen-free anodic oxidation??
  M. Sheykhan,S. Khani,S. Shaabanzadeh,M. Joafshan Green Chem., 2017,19, 5940-5948
• 5. An inter-tangled network of redox-active and conducting polymers as a cathode for ultrafast rechargeable batteries
  Jieun Kim,Han-Saem Park,Tae-Hee Kim,Sung Yeol Kim,Hyun-Kon Song Phys. Chem. Chem. Phys., 2014,16, 5295-5300

• Solvents and Organic Chemicals Organic Compounds Hydrocarbons

Introduction to Sodium Salt of 4-Hydroxybenzenesulfonic Acid (CAS No. 825-90-1)

The Sodium Salt of 4-Hydroxybenzenesulfonic Acid, with the chemical identifier CAS No. 825-90-1, is a widely recognized compound in the field of pharmaceuticals and chemical research. This compound, also known as sodium 4-hydroxybenzenesulfonate, has garnered significant attention due to its versatile applications and the growing body of research surrounding its properties and potential uses.

4-Hydroxybenzenesulfonic acid sodium salt is an important intermediate in the synthesis of various pharmaceuticals and specialty chemicals. Its unique structure, featuring both a hydroxyl group and a sulfonate group, makes it a valuable building block for more complex molecules. The sulfonate group enhances its solubility in water, while the hydroxyl group allows for further functionalization, making it a versatile reagent in organic synthesis.

Recent studies have highlighted the potential of Sodium Salt of 4-Hydroxybenzenesulfonic Acid in drug development. Its ability to act as a chelating agent has been explored in the design of metal-based drugs, which are being investigated for their efficacy in treating various diseases, including cancer. The compound's stability under different pH conditions also makes it suitable for use in formulations that require controlled release mechanisms.

In addition to its pharmaceutical applications, Sodium Salt of 4-Hydroxybenzenesulfonic Acid has found utility in industrial processes. It is used as a surfactant and corrosion inhibitor in various manufacturing processes. Its ability to form stable complexes with metals makes it effective in preventing corrosion in metal surfaces, thereby extending the lifespan of industrial equipment.

The compound's role in environmental chemistry cannot be overlooked either. Researchers have been investigating its potential use in water treatment processes. Its chelating properties help in removing heavy metals from wastewater, making it an environmentally friendly option for water purification. The increasing emphasis on sustainable practices has led to a surge in research focused on optimizing the use of Sodium Salt of 4-Hydroxybenzenesulfonic Acid in such applications.

The synthesis of Sodium Salt of 4-Hydroxybenzenesulfonic Acid typically involves the sulfonation of phenol followed by neutralization with sodium hydroxide. This process is well-documented and widely used due to its efficiency and scalability. Advances in synthetic methodologies have further refined this process, leading to higher yields and purer products. These improvements have not only enhanced the cost-effectiveness of producing the compound but also opened up new avenues for its application.

The pharmacological properties of Sodium Salt of 4-Hydroxybenzenesulfonic Acid have been extensively studied. Research indicates that it exhibits antioxidant properties, which could be beneficial in combating oxidative stress-related diseases. Additionally, its ability to modulate enzyme activity has led to investigations into its potential as an anti-inflammatory agent. These findings have sparked interest among researchers looking for novel therapeutic agents.

In conclusion, the Sodium Salt of 4-Hydroxybenzenesulfonic Acid (CAS No. 825-90-1) is a multifaceted compound with significant applications across various sectors. Its role in pharmaceuticals, industrial processes, and environmental chemistry underscores its importance as a chemical intermediate. As research continues to uncover new uses and benefits, the demand for high-quality Sodium Salt of 4-Hydroxybenzenesulfonic Acid is expected to grow, driving further innovation and development.

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