Cas no 82380-18-5 (2-Fluoro-4-hydroxybenzonitrile)

2-Fluoro-4-hydroxybenzonitrile structure
82380-18-5 structure
Product Name:2-Fluoro-4-hydroxybenzonitrile
CAS No:82380-18-5
MF:C7H4FNO
MW:137.111165046692
MDL:MFCD00192177
CID:60432
PubChem ID:24866150
Update Time:2024-10-27

2-Fluoro-4-hydroxybenzonitrile Chemical and Physical Properties

Names and Identifiers

    • 4-Cyano-3-fluorophenol
    • 2-FLUORO-4-HYDROXYBENZONITRILE (4-CYANO-3-FLUOROPHENOL)
    • FCP
    • 2-Fluoro-4-hydroxybe
    • 4-Cyano-3-fluorophenol 4-Hydroxy-2-fluorobenzonitrile
    • 2-FLUORO-4-HYDROXYBENZONITRILE FOR SYNTH
    • 3-fluoro-4-cyanopehenol
    • Fluoro-4-hydroxybenzonitr
    • 2-Fluoro-4-hydroxybenzonitrile
    • 2-FLUORO-4-BENZONITRILE
    • 4-Hydroxy-2-fluorobenzonitrile
    • 3-fluoro-4-cyanophenol
    • BENZONITRILE, 2-FLUORO-4-HYDROXY-
    • 2-fluoro-4-hydroxybenzenecarbonitrile
    • 2-fluoro-4-hydroxy-benzonitrile
    • 8H8
    • PubChem3495
    • PubChem2610
    • 4wh7
    • fluoro-4-hydroxybenzonitrile
    • 2-fluoro4-hydroxybenzonitrile
    • KSC448A5L
    • 6-fluoro-4-hydroxy benzonitrile
    • 4-hydroxy-2-fluoro-benzo
    • 2-Fluoro-4-hydroxybenzonitrile, 99% 5GR
    • 4-Cyano-3-fluorophenol 4-Hydroxy-2-fluorobenzonitrile
    • 2-Fluoro-4-hydroxybenzonitrile (ACI)
    • 4-Nitrile-3-fluorophenol
    • 2-Fluoro-4-hydroxybenzonitrile,99%
    • 2-Fluoro-4-hydroxybenzonitrile, 99%
    • W-200564
    • DS-1517
    • F0462
    • J-512485
    • 2-Fluoro-4-hydroxy benzonitrile
    • DTXSID30370440
    • InChI=1/C7H4FNO/c8-7-3-6(10)2-1-5(7)4-9/h1-3,10
    • AB04647
    • CS-W007999
    • F9994-0496
    • DB-028062
    • AC-4069
    • BH-0414
    • MFCD00192177
    • BP-20210
    • Q27456884
    • NS00038195
    • 82380-18-5
    • 3-FLUORO-4-HYDROXYBENZONITRILE (4-CYANO-2-FLUOROPHENOL)
    • EN300-73306
    • SCHEMBL176946
    • AKOS005063965
    • SY016474
    • Z1157728598
    • EC 422-810-7
    • DB-056663
    • 4-hydroxy-2-fluoro-benzonitrile
    • MDL： MFCD00192177
    • Inchi： 1S/C7H4FNO/c8-7-3-6(10)2-1-5(7)4-9/h1-3,10H
    • InChI Key： REIVHYDACHXPNH-UHFFFAOYSA-N
    • SMILES： N#CC1C(F)=CC(O)=CC=1
    • BRN： 4741066

Computed Properties

  • Exact Mass: 137.028
  • Monoisotopic Mass: 137.028
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 1
  • Hydrogen Bond Acceptor Count: 3
  • Heavy Atom Count: 10
  • Rotatable Bond Count: 0
  • Complexity: 162
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Surface Charge: 0
  • Tautomer Count: 3
  • XLogP3: 1.4
  • Topological Polar Surface Area: 44

Experimental Properties

  • Color/Form: solid
  • Density: 1.450(lit.)
  • Melting Point: 123.0 to 127.0 deg-C
  • Boiling Point: 285.4±25.0 °C at 760 mmHg
  • Flash Point: 126.4℃
  • Refractive Index: 1.558
  • PH: 4.2 (H2O, 20℃)(saturated aqueous solution)
  • Solubility: 4.7g/l
  • PSA: 44.02000
  • LogP: 1.40298
  • Solubility: Not determined

2-Fluoro-4-hydroxybenzonitrile Security Information

  • Symbol: GHS05 GHS07 GHS09
  • Prompt：warning
  • Signal Word：Danger
  • Hazard Statement： H302,H318,H411
  • Warning Statement： P273,P280,P305+P351+P338
  • Hazardous Material transportation number：UN 3077 9 / PGIII
  • WGK Germany：2
  • Hazard Category Code： 20/21/22-36/37/38
  • Safety Instruction： 26-36
  • Hazardous Material Identification： Xn
  • HazardClass：9
  • PackingGroup：III
  • Storage Condition：Store at room temperature

2-Fluoro-4-hydroxybenzonitrile Customs Data

  • HS CODE：29269095

2-Fluoro-4-hydroxybenzonitrile Pricemore >>

Related Categories No. Product Name Cas No. Purity Specification Price update time Inquiry
Fluorochem
008675-1g
2-Fluoro-4-hydroxybenzonitrile
 82380-18-5 98%
1g
 ￡10.00 2022-02-28
Fluorochem
008675-5g
2-Fluoro-4-hydroxybenzonitrile
 82380-18-5 98%
5g
 ￡11.00 2022-02-28
Fluorochem
008675-10g
2-Fluoro-4-hydroxybenzonitrile
 82380-18-5 98%
10g
 ￡19.00 2022-02-28
Fluorochem
008675-25g
2-Fluoro-4-hydroxybenzonitrile
 82380-18-5 98%
25g
 ￡31.00 2022-02-28
Fluorochem
008675-100g
2-Fluoro-4-hydroxybenzonitrile
 82380-18-5 98%
100g
 ￡83.00 2022-02-28
SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd.
F103201-1g
2-Fluoro-4-hydroxybenzonitrile
 82380-18-5 99%
1g
 ￥29.90 2023-09-03
SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd.
F103201-25g
2-Fluoro-4-hydroxybenzonitrile
 82380-18-5 99%
25g
 ￥116.90 2023-09-03
SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd.
F103201-5g
2-Fluoro-4-hydroxybenzonitrile
 82380-18-5 99%
5g
 ￥30.90 2023-09-03
SHANG HAI YI EN HUA XUE JI SHU Co., Ltd.
R010328-1g
2-Fluoro-4-hydroxybenzonitrile
 82380-18-5 97%
1g
 ￥83 2024-05-21
SHANG HAI YI EN HUA XUE JI SHU Co., Ltd.
R010328-25g
2-Fluoro-4-hydroxybenzonitrile
 82380-18-5 97%
25g
 ￥670 2024-05-21

2-Fluoro-4-hydroxybenzonitrile Production Method

Production Method 1

Reaction Conditions
1.1 Reagents: Cesium carbonate ,  Sodium iodide Solvents: Dimethylformamide ;  12 h, 55 °C
Reference
Application of Aryloximes as Solid-Phase Ketone Linkers
Lepore, Salvatore D.; et al, Organic Letters, 2003, 5(1), 7-10

Production Method 2

Reaction Conditions
1.1 Reagents: Formic acid ,  Triethylamine ,  Oxygen Catalysts: Copper bromide (CuBr) Solvents: Acetonitrile ;  5 min, rt; 48 h, rt
Reference
Synergistic Photo-Copper-Catalyzed Hydroxylation of (Hetero)aryl Halides with Molecular Oxygen
Zhang, Xin; et al, Organic Letters, 2018, 20(3), 708-711

Production Method 3

Reaction Conditions
1.1 Reagents: Diisopropylethylamine ,  Water Catalysts: Nickel sulfate (NiSO4) ,  4,4′-Dimethoxy-2,2′-bipyridine ,  2767997-30-6 Solvents: Acetonitrile ;  24 h, rt
1.2 Reagents: Water ;  rt
Reference
Discovery and characterization of a novel perylenephotoreductant for the activation of aryl halides
Li, Min; et al, Journal of Catalysis, 2021, 399, 111-120

Production Method 4

Reaction Conditions
1.1 Reagents: Sodium acetate ,  Hydroxyamine hydrochloride Solvents: Formic acid ,  Water ;  12 h, 80 °C
Reference
One pot synthesis of aryl nitriles from aromatic aldehydes in a water environment
Lin, Hongyan; et al, RSC Advances, 2021, 11(39), 24232-24237

Production Method 5

Reaction Conditions
Reference
Benzoate derivatives having positive dielectric anisotropy and liquid crystal compositions containing them
, European Patent Organization, , ,

Production Method 6

Reaction Conditions
1.1 Reagents: Aluminum chloride Solvents: Toluene
Reference
Preparation of cyanofluorophenol from 2,4-difluorobenzonitrile and alcohols
, Japan, , ,

Production Method 7

Reaction Conditions
1.1 Solvents: Dimethylformamide ;  8 h, reflux
Reference
Synthesis, mesomorphic and fluorescent properties of 1,3,4-oxadiazoles/thiadiazoles with a terminal 3-fluoro-4-cyanophenyl group
Zhong, Wen-Yue; et al, Tetrahedron, 2023, 144,

Production Method 8

Reaction Conditions
1.1 Catalysts: Sodium cyanide Solvents: Dimethylformamide ;  3 - 8 h, reflux
Reference
Study on the preparation of 3-fluoro-4-cyanophenol
Zhuang, Xin-jie; et al, Qingdao Keji Daxue Xuebao, 2003, 24(1), 24-27

Production Method 9

Reaction Conditions
Reference
Liquid-crystal compositions containing 3-fluoro-4-cyanophenyl trans-4-(4-substituted phenyl)cyclohexanecarboxlates
, Japan, , ,

Production Method 10

Reaction Conditions
1.1 Reagents: Hydrogen ,  Sulfuric acid Catalysts: Hexadecyltrimethylammonium bromide ,  Tetrabutylammonium bromide ,  Platinum ,  Sulfuric acid magnesium salt (1:1) Solvents: Water ;  4 h, 1.6 - 1.8 atm, rt; rt → -5 °C
1.2 Reagents: Sodium nitrite Solvents: Water ;  -5 °C; 30 min, 0 - 5 °C
1.3 Reagents: Potassium iodide Catalysts: Sodium thiosulfate Solvents: Water ;  0 - 5 °C; 30 min, 5 °C → 30 °C; 3 h, 40 °C → 60 °C
2.1 Solvents: Dimethylformamide ;  8 h, reflux
Reference
Synthesis, mesomorphic and fluorescent properties of 1,3,4-oxadiazoles/thiadiazoles with a terminal 3-fluoro-4-cyanophenyl group
Zhong, Wen-Yue; et al, Tetrahedron, 2023, 144,

Production Method 11

Reaction Conditions
1.1 Reagents: Sodium hydroxide ,  Iodine ,  β-Cyclodextrin ,  Potassium iodide Solvents: Water ;  pH 2 - 3, 0 - 5 °C
2.1 Catalysts: Sodium cyanide Solvents: Dimethylformamide ;  3 - 8 h, reflux
Reference
Study on the preparation of 3-fluoro-4-cyanophenol
Zhuang, Xin-jie; et al, Qingdao Keji Daxue Xuebao, 2003, 24(1), 24-27

Production Method 12

Reaction Conditions
1.1 Solvents: Methanol
2.1 Reagents: Aluminum chloride Solvents: Toluene
Reference
Preparation of cyanofluorophenol from 2,4-difluorobenzonitrile and alcohols
, Japan, , ,

2-Fluoro-4-hydroxybenzonitrile Raw materials

2-Fluoro-4-hydroxybenzonitrile Preparation Products

2-Fluoro-4-hydroxybenzonitrile Suppliers

Amadis Chemical Company Limited
Gold Member
Audited Supplier Audited Supplier
(CAS:82380-18-5)3-Fluoro-4-Cyanophenol
Order Number:A10027
Stock Status:in Stock
Quantity:500g
Purity:99%
Pricing Information Last Updated:Thursday, 29 August 2024 14:59
Price ($):250.0
Suzhou Senfeida Chemical Co., Ltd
Gold Member
Audited Supplier Audited Supplier
(CAS:82380-18-5)2-Fluoro-4-hydroxybenzonitrile
Order Number:sfd22457
Stock Status:in Stock
Quantity:200kg
Purity:99.9%
Pricing Information Last Updated:Friday, 19 July 2024 14:39
Price ($):discuss personally
Jiangsu Xinsu New Materials Co., Ltd
Gold Member
Audited Supplier Audited Supplier
(CAS:82380-18-5)
Order Number:SFD906
Stock Status:in Stock
Quantity:25KG,200KG,1000KG
Purity:99%
Pricing Information Last Updated:Wednesday, 11 December 2024 17:02
Price ($):

2-Fluoro-4-hydroxybenzonitrile Related Literature

Related Categories

82380-18-5 (2-Fluoro-4-hydroxybenzonitrile) Related Products

Recommended suppliers
Amadis Chemical Company Limited
(CAS:82380-18-5)3-Fluoro-4-Cyanophenol
A10027
Purity:99%
Quantity:500g
Price ($):250.0
Email
Suzhou Senfeida Chemical Co., Ltd
(CAS:82380-18-5)2-Fluoro-4-hydroxybenzonitrile
sfd22457
Purity:99.9%
Quantity:200kg
Price ($):Inquiry
Email