Production Method 1

998-40-3

82358-61-0

Reaction Conditions

1.1 Reagents: Nitromethane ;  15 min, < 50 °C; 16 h, rt

Reference

A Convenient Method for the Asymmetric Synthesis of Fluorinated α-Amino Acids from Alcohols

Drouet, Fleur; et al, European Journal of Organic Chemistry, 2014, 2014(6), 1195-1201

Production Method 2

998-40-3

82358-61-0

Reaction Conditions

1.1 Solvents: Nitromethane ;  > 50 °C; 16 h, rt

Reference

Preparation of (Cyanomethylene)tributylphosphorane: A new Mitsunobu-type reagent

Sakamoto, Izumi; et al, Chemical & Pharmaceutical Bulletin, 2005, 53(11), 1508-1509

Production Method 3

998-40-3

82358-61-0

Reaction Conditions

1.1 Solvents: Nitromethane

Reference

New Narwedine and Galanthamine Derivatives as Potential Alzheimer Therapeutics

Welzig, Stefan, 1997, , ,

Tributyl(cyanomethyl)phosphonium Chloride Raw materials

• Tributyl Phosphine

Tributyl(cyanomethyl)phosphonium Chloride Preparation Products

• Tributyl(cyanomethyl)phosphonium Chloride (82358-61-0)

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• Solvents and Organic Chemicals Organic Compounds Organophosphorus compounds Tetraalkylphosphonium compounds
• Catalysts and Inorganic Chemicals Catalysts

Recent Advances in the Application of Tributyl(cyanomethyl)phosphonium Chloride (CAS: 82358-61-0) in Chemical Biology and Pharmaceutical Research

Tributyl(cyanomethyl)phosphonium Chloride (CAS: 82358-61-0) is a versatile organophosphorus compound that has garnered significant attention in recent years due to its unique chemical properties and potential applications in chemical biology and pharmaceutical research. This research briefing aims to provide an overview of the latest advancements in the utilization of this compound, focusing on its role as a key intermediate in organic synthesis, its biological activities, and its emerging applications in drug discovery and development.

Recent studies have highlighted the importance of Tributyl(cyanomethyl)phosphonium Chloride as a precursor in the synthesis of various biologically active molecules. Its ability to act as a phosphonium ylide precursor has been exploited in the construction of complex molecular architectures, including heterocyclic compounds and functionalized alkenes. A 2023 study published in the Journal of Organic Chemistry demonstrated its efficacy in facilitating the Wittig reaction under mild conditions, yielding high-purity products with excellent stereoselectivity.

In the realm of chemical biology, researchers have explored the compound's potential as a protein modification reagent. The phosphonium moiety's unique reactivity allows for selective labeling of cysteine residues in proteins, enabling the study of protein-protein interactions and post-translational modifications. A recent Nature Chemical Biology paper (2024) reported the development of a novel probe based on Tributyl(cyanomethyl)phosphonium Chloride for real-time monitoring of enzymatic activity in live cells.

Pharmaceutical applications of this compound have expanded significantly, particularly in the development of kinase inhibitors and antimicrobial agents. Its structural features make it an attractive scaffold for designing small molecule modulators of various biological targets. A 2024 study in the European Journal of Medicinal Chemistry described a series of novel anticancer agents derived from Tributyl(cyanomethyl)phosphonium Chloride derivatives, showing promising activity against multiple cancer cell lines with improved selectivity profiles.

The safety profile and pharmacokinetic properties of Tributyl(cyanomethyl)phosphonium Chloride derivatives have been the subject of recent investigations. While the parent compound shows moderate cytotoxicity, structural modifications have been shown to significantly improve biocompatibility. Current research efforts are focused on optimizing the compound's properties for in vivo applications, with particular attention to reducing off-target effects and improving metabolic stability.

Looking forward, the unique chemical properties of Tributyl(cyanomethyl)phosphonium Chloride continue to inspire innovative applications across multiple disciplines. Its combination of synthetic versatility and biological activity makes it a valuable tool for both fundamental research and applied pharmaceutical development. Future research directions may include exploring its potential in targeted drug delivery systems and as a component of novel biomaterials for medical applications.

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