Production Method 1

25322-68-3

82209-36-7

Reaction Conditions

1.1 Reagents: Thionyl chloride ;  cooled; rt; 22 h, rt
1.2 Reagents: Sodium azide Solvents: Dimethylformamide ;  16 h, 85 °C
1.3 Reagents: Triphenylphosphine Solvents: Tetrahydrofuran ;  24 h, rt
1.4 Reagents: Water ;  24 h, rt

Reference

Selective Inhibition of Human Brain Tumor Cells through Multifunctional Quantum-Dot-Based siRNA Delivery

Jung, Jongjin; et al, Angewandte Chemie, 2010, 49(1), 103-107

Production Method 2

3386-18-3

82209-36-7

Reaction Conditions

1.1 Reagents: Thionyl chloride ;  0 °C; 0 °C → 25 °C; 2 h, 25 °C
1.2 Reagents: Sodium azide Solvents: Dimethylformamide ;  12 h, 85 °C
1.3 Reagents: Triphenylphosphine Solvents: Tetrahydrofuran ,  Water ;  4 h, 25 °C; 12 h

Reference

Monovalent, reduced-size quantum dots for imaging receptors on living cells

Howarth, Mark; et al, Nature Methods, 2008, 5(5), 397-399

Amino-PEG8-amine Raw materials

• Polyethylene Glycol
• Nonaethylene glycol

Amino-PEG8-amine Preparation Products

• Amino-PEG8-amine (82209-36-7)

• 1. An amplified fluorescence detection of T4 polynucleotide kinase activity based on coupled exonuclease III reaction and a graphene oxide platform?
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  Rongning Liang,Tanji Yin,Ruiqing Yao,Wei Qin RSC Adv., 2016,6, 73308-73312
• 5. An assay for the enzyme N-acetyl-β-d-glucosaminidase (NAGase) based on electrochemical detection using screen-printed carbon electrodes (SPCEs)
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• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Dialkyl ethers
• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Ethers Dialkyl ethers

Professional Introduction to Compound with CAS No. 82209-36-7 and Product Name: Amino-PEG8-amine

The compound with CAS No. 82209-36-7 and the product name Amino-PEG8-amine represents a significant advancement in the field of pharmaceutical chemistry and biotechnology. This compound, characterized by its unique molecular structure, has garnered considerable attention due to its versatile applications in drug delivery systems, biomaterials, and therapeutic agents. The presence of both amino and polyethylene glycol (PEG) functional groups makes it a highly valuable intermediate in the synthesis of novel biomolecules and pharmacological agents.

Amino-PEG8-amine is a derivative of polyethylene glycol (PEG), which is renowned for its biocompatibility, stability, and ability to enhance the pharmacokinetic properties of therapeutic agents. The introduction of amino groups into the PEG chain introduces reactive sites that can be utilized for further chemical modifications, enabling the development of complex conjugates and prodrugs. This flexibility has made Amino-PEG8-amine a cornerstone in the design of targeted drug delivery systems, where it serves as a linker between therapeutic moieties and targeting ligands.

Recent advancements in nanomedicine have highlighted the importance of PEG-based polymers in improving the efficacy and safety of drug formulations. Studies have demonstrated that PEGylation, the process of attaching PEG chains to molecules, can significantly reduce immunogenicity and increase circulation time in vivo. Amino-PEG8-amine, with its bifunctional nature, offers an excellent platform for such modifications. For instance, researchers have utilized this compound to develop polymeric micelles that can encapsulate hydrophobic drugs, enhancing their solubility and bioavailability.

In the realm of biomaterials, Amino-PEG8-amine has been explored for its potential in creating biodegradable scaffolds for tissue engineering. The PEG moiety provides hydrophilicity, while the amino groups allow for covalent attachment to biomolecules such as growth factors and cytokines. This has led to promising results in regenerative medicine, where controlled release of bioactive molecules is crucial for tissue repair and regeneration.

Moreover, the pharmaceutical industry has leveraged Amino-PEG8-amine in the development of enzyme inhibitors and receptor antagonists. The PEG chain acts as a steric barrier, reducing enzyme degradation while maintaining binding affinity. For example, conjugates of therapeutic proteins with Amino-PEG8-amine have shown prolonged half-lives in clinical trials, reducing dosing frequency and improving patient compliance.

One of the most exciting applications of Amino-PEG8-amine is in the field of antibody-drug conjugates (ADCs). ADCs are a class of biopharmaceuticals designed to deliver cytotoxic agents directly to cancer cells while minimizing systemic toxicity. The PEG moiety in Amino-PEG8-amine helps mask the antibody from rapid clearance by phagocytic cells, thereby extending its circulation time. This property is critical for ensuring that the payload reaches its target site effectively.

Recent studies have also explored the use of Amino-PEG8-amine in gene therapy vectors. The ability to modify both ends of the PEG chain allows for the creation of compact and stable nucleic acid delivery systems. These vectors have shown promise in delivering therapeutic genes to target tissues with high efficiency, opening new avenues for treating genetic disorders.

The synthetic route to Amino-PEG8-amine involves well-established chemical methodologies that ensure high purity and yield. The process typically begins with the polymerization of ethylene oxide to form PEG chains of desired molecular weight. Subsequent functionalization introduces amino groups at both ends of the chain using reagents such as hydrazine or diamines. This step is critical for achieving the desired bifunctional nature of the compound.

Quality control measures are stringent to ensure that Amino-PEG8-amine meets pharmaceutical-grade standards. Analytical techniques such as high-performance liquid chromatography (HPLC), nuclear magnetic resonance (NMR) spectroscopy, and mass spectrometry are employed to verify purity and structural integrity. These methods provide confidence that the compound will perform consistently in biological systems.

The versatility of Amino-PEG8-amine extends beyond its applications in pharmaceuticals. Researchers have also utilized this compound in diagnostic imaging agents, where it serves as a contrast agent for magnetic resonance imaging (MRI). The PEG moiety enhances relaxivity while allowing for further functionalization with targeting ligands.

In conclusion,Amino-PEG8-amine represents a multifaceted compound with broad applications across multiple disciplines within chemistry and biology. Its unique properties make it an indispensable tool for developing innovative therapeutics and biomaterials. As research continues to uncover new uses for this compound, its significance is likely to grow even further.

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