Production Method 1

105163-69-7

822-27-5

Reaction Conditions

1.1 Reagents: Aniline ,  tert-Butyl hypochlorite Solvents: Dichloromethane

Reference

2-(4-Pyridyl)ethyl as a protective group for sulfur functionality

Katritzky, Alan R.; et al, Journal of Organic Chemistry, 1986, 51(25), 4914-20

Production Method 2

27970-36-1

822-27-5

Reaction Conditions

1.1 Reagents: Samarium Solvents: Tetrahydrofuran
1.2 Reagents: Ammonium chloride Solvents: Water

Reference

Metallic samarium promoted reductive dimerization cyclization of gem-diactivated alkenes, reductive debromination of vic-dibromides, and reduction of sodium alkyl thiosulfates in aqueous media

Wang, Lei; et al, Tetrahedron, 1999, 55(35), 10695-10712

Production Method 3

19942-78-0

822-27-5

Reaction Conditions

1.1 Reagents: Amberlyst A 26OH Solvents: Water ;  5 h, 60 °C

Reference

An efficient metal-free synthesis of organic disulfides from thiocyanates using poly-ionic resin hydroxide in aqueous medium

Sengupta, Debasish; et al, Tetrahedron Letters, 2013, 54(18), 2277-2281

Production Method 4

822-27-5

Reaction Conditions

1.1 Reagents: Iodine Solvents: Methanol ;  rt; 10 min, rt

Reference

Design, synthesis, and biological evaluation of largazole derivatives: alteration of the zinc-binding domain

Su, Jinyue; et al, Tetrahedron, 2014, 70(42), 7763-7769

Production Method 5

78622-30-7

822-27-5

Reaction Conditions

Reference

Reduction of organic sulfonic acids, sodium sulfonates, and sulfonic esters to the corresponding disulfides with polyphosphoric acid derivatives, potassium iodide and the tetrabutylammonium iodide system

Oae, Shigeru; et al, Bulletin of the Chemical Society of Japan, 1983, 56(12), 3813-17

Production Method 6

111-83-1

2720-80-1

822-27-5

Reaction Conditions

Reference

Rearrangement of O,S-dialkyl dithiocarbonates to S,S-dialkyl dithiocarbonates catalyzed by tricaprylmethylammonium chloride

Degani, Iacopo; et al, Synthesis, 1981, (2), 149-51

Production Method 7

822-27-5

Reaction Conditions

1.1 Reagents: S8 Catalysts: 2-tert-Butyl-1,1,3,3-tetramethylguanidine ;  25 °C → 90 °C; 22 min, 90 °C

Reference

Organic superbase-catalyzed oxidation of alkanethiols to dialkyl disulfides by elemental sulfur

Zhang, Zihan; et al, Research on Chemical Intermediates, 2023, 49(10), 4503-4521

Production Method 8

94805-33-1

822-27-5

Reaction Conditions

1.1 Reagents: Methanaminium, N,N,N-trimethyl-, (T-4)-fluorotrioxochromate(1-) (1:1) Solvents: Acetonitrile ;  160 min, rt

Reference

Oxidation coupling of organic thiols to disulphides with tetramethylammonium fluorochromate(VI) (TMAFC)

Imanieh, Hosein; et al, Proceedings of ECSOC-10, 2006, ,

Production Method 9

111-83-1

822-27-5

Reaction Conditions

1.1 Reagents: Potassium sulfide Catalysts: Acetylacetone ,  Nickel chloride hexahydrate Solvents: Dimethylformamide ,  Water ;  6 h, 110 °C; 110 °C → rt
1.2 Reagents: Hydrochloric acid Solvents: Water ;  pH 7

Reference

Symmetrical disulfide synthesis via nickel-catalysis using potassium sulfide as sulfur source

Soleiman-Beigi, Mohammad; et al, Monatshefte fuer Chemie, 2016, 147(10), 1759-1763

Production Method 10

629-27-6

822-27-5

Reaction Conditions

1.1 Reagents: Thiourea ,  Sodium bicarbonate Catalysts: Cobalt phthalocyanine (sulfonated) Solvents: Water ,  Polyethylene glycol ;  2 h, 80 - 90 °C

Reference

Europhtal (8020) efficiently catalyzes the aerobic oxidation of in situ generated thiols to symmetric disulfides (disulfanes)

Abbasi, Mohammad; et al, Journal of Organometallic Chemistry, 2017, 833, 10-17

Production Method 11

629-27-6

822-27-5

Reaction Conditions

1.1 Reagents: Thiourea ,  Sodium bicarbonate ,  Manganese oxide (MnO2) Catalysts: Sodium dodecyl sulfate Solvents: Water ;  3.5 h, 80 °C

Reference

Distinct catalytic effect of micellar solution of sodium dodecyl sulfate (SDS) for one-pot conversion of alkyl halides to disulfides via an odorless process using thiourea and MnO2

Firouzabadi, Habib; et al, Bulletin of the Chemical Society of Japan, 2010, 83(6), 698-702

Production Method 12

629-27-6

822-27-5

Reaction Conditions

1.1 Reagents: Thiourea ,  Sodium carbonate ,  Manganese oxide (MnO2) Solvents: Water ,  Polyethylene glycol ;  10 h, 30 - 35 °C

Reference

A one-pot, efficient, and odorless synthesis of symmetrical disulfides using organic halides and thiourea in the presence of manganese dioxide and wet polyethylene glycol (PEG-200)

Firouzabadi, Habib; et al, Tetrahedron Letters, 2010, 51(3), 508-509

Production Method 13

3386-35-4

822-27-5

Reaction Conditions

1.1 Reagents: Thiourea ,  Sodium carbonate ,  Graphene (oxide) Solvents: Acetonitrile ,  Water ;  3 - 12 h, 80 °C

Reference

Graphene Oxide-Assisted One-Pot and Odorless Synthesis of Symmetrical Disulfides Using Primary and Secondary Alkyl Halides (Tosylates) and Thiourea as Sulfur Source Reagent

Khalili, Dariush, Phosphorus, 2015, 190(11), 1727-1734

Production Method 14

822-27-5

Reaction Conditions

1.1 Reagents: Sodium iodide ,  Hydrogen peroxide Solvents: Ethyl acetate ,  Water ;  rt; 1 h, rt

Reference

Palladium-Catalyzed Carbonylative Synthesis of Aryl Selenoesters Using Formic Acid as an Ex Situ CO Source

Yano de Albuquerque, Danilo ; et al, Journal of Organic Chemistry, 2022, 87(1), 595-605

Production Method 15

94805-33-1

822-27-5

Reaction Conditions

1.1 Reagents: Permanganic acid (HMnO4), potassium salt (1:1) Solvents: Dichloromethane ;  2.45 h, reflux

Reference

Ion exchange catalysis in oxidation of organic compounds with KMnO4

Shaabani, Ahmad; et al, Synthetic Communications, 2003, 33(6), 1057-1065

Production Method 16

2432-34-0

822-27-5

Reaction Conditions

1.1 Reagents: Nickel acetate Solvents: Methanol

Reference

A convenient one-pot synthesis of disulfides from thioacetates via nickel boride catalyzed methanolysis and disproportionation

Choi, Jaesung; et al, Synlett, 1995, (10), 1073-4

Production Method 17

111-83-1

822-27-5

Reaction Conditions

1.1 Reagents: Thiourea ,  Sodium bicarbonate Catalysts: Cobalt phthalocyanine (sulfonated) Solvents: Water ,  Polyethylene glycol ;  3 h, 80 - 90 °C

Reference

Europhtal (8020) efficiently catalyzes the aerobic oxidation of in situ generated thiols to symmetric disulfides (disulfanes)

Abbasi, Mohammad; et al, Journal of Organometallic Chemistry, 2017, 833, 10-17

Production Method 18

111-83-1

822-27-5

Reaction Conditions

1.1 Reagents: Carbon tetrachloride ,  Sodium sulfide (Na2S), hydrate (1:3) Solvents: Polyethylene glycol ;  90 min, rt

Reference

One-Pot Synthesis of Organic Disulfides (Disulfanes) from Alkyl Halides Using Sodium Sulfide Trihydrate and Hexachloroethane or Carbon Tetrachloride in the Poly(ethylene glycol) (PEG-200)

Abbasi, Mohammad; et al, Synlett, 2015, 26(9), 1185-1190

Production Method 19

3386-35-4

822-27-5

Reaction Conditions

1.1 Reagents: Sodium hydroxide ,  Silica ,  S8 ;  3 min; 5 min

Reference

Facile solvent-free generation of disulfide dianion and its use for preparation of symmetrical disulfides

Kiasat, Ali Reza; et al, Phosphorus, 2008, 183(1), 178-182

Production Method 20

3386-35-4

822-27-5

Reaction Conditions

1.1 Reagents: Thiourea ,  Sodium carbonate ,  S8 Solvents: Water ,  Polyethylene glycol ;  12 h, 70 °C

Reference

One-pot efficient synthesis of disulfides from alkyl halides and alkyl tosylates using thiourea and elemental sulfur without contamination by higher polysulfides

Abbasi, Mohammad; et al, Journal of the Iranian Chemical Society, 2013, 10(2), 201-205

Production Method 21

27970-36-1

822-27-5

Reaction Conditions

1.1 Reagents: Samarium ,  Titanium tetrachloride Solvents: Tetrahydrofuran

Reference

Novel reduction of sodium alkyl thiosulfates to disulfides with the TiCl4/Sm system

Guo, Hong Yun; et al, Chinese Chemical Letters, 1997, 8(3), 191-192

Production Method 22

27970-36-1

822-27-5

Reaction Conditions

1.1 Reagents: Samarium Solvents: Water ;  4 h, 90 °C

Reference

A novel reduction of sodium alkyl thiosulfates using samarium metal without an activating agent in water

Wang, Lei; et al, Tetrahedron Letters, 2002, 43(45), 8141-8143

Production Method 23

111-87-5

822-27-5

Reaction Conditions

1.1 Reagents: Triphenylphosphine Catalysts: 4,4′-Azopyridine Solvents: Acetonitrile ;  20 min, 80 °C
1.2 Reagents: Ammonium thiocyanate ;  5 h, 80 °C

Reference

Heteroaromatic azo compounds as efficient and recyclable reagents for direct conversion of aliphatic alcohols into symmetrical disulfides

Iranpoor, Nasser; et al, Tetrahedron Letters, 2012, 53(51), 6913-6915

Production Method 24

111-87-5

822-27-5

Reaction Conditions

1.1 Reagents: Dicyclohexylcarbodiimide ,  Cuprous chloride
1.2 Catalysts: Benzenemethanaminium, N,N,N-triethyl-, (T-4)-tetrathioxomolybdate(2-) (2:1) Solvents: Acetonitrile

Reference

One-pot conversion of alcohols to disulfides mediated by benzyltriethylammonium tetrathiomolybdate

Sinha, Surajit; et al, Tetrahedron, 1999, 55(51), 14769-14776

Production Method 25

19942-78-0

822-27-5

Reaction Conditions

1.1 Reagents: Samarium ,  Titanium tetrachloride Solvents: Tetrahydrofuran

Reference

Preparation of dialkyl disulfides via reduction of alkyl thiocyanates with TiCl4/Sm system

Guo, Hongyun; et al, Synthetic Communications, 1997, 27(15), 2721-2724

Production Method 26

19942-78-0

822-27-5

Reaction Conditions

1.1 Reagents: Titanocene dichloride ,  Samarium Solvents: Tetrahydrofuran ;  0.5 h, 70 °C
1.2 Solvents: Tetrahydrofuran ;  0 °C; 0 °C → rt; 0.5 h, rt

Reference

Reductive cleavage of the carbon-sulfur bond by samarium/Cp2TiCl2 system for the synthesis of dialkyl disulfides

Jia, Xue-Shun; et al, Chinese Journal of Chemistry, 2005, 23(3), 303-304

Production Method 27

10489-23-3

822-27-5

Reaction Conditions

1.1 Reagents: Hexamethylphosphoramide ,  Samarium iodide (SmI2) Solvents: Tetrahydrofuran
1.2 Reagents: Hydrochloric acid Solvents: Water

Reference

Novel reductive cleavage reaction of thiobenzoates with samarium diiodide: convenient synthesis of disulfides

Yoo, Byung Woo; et al, Synthetic Communications, 2000, 30(23), 4317-4322

Production Method 28

3944-72-7

822-27-5

Reaction Conditions

Reference

Reduction of organic sulfonic acids, sodium sulfonates, and sulfonic esters to the corresponding disulfides with polyphosphoric acid derivatives, potassium iodide and the tetrabutylammonium iodide system

Oae, Shigeru; et al, Bulletin of the Chemical Society of Japan, 1983, 56(12), 3813-17

Production Method 29

7795-95-1

822-27-5

Reaction Conditions

1.1 Reagents: Hydrotritelluride, boryl-, sodium salt (1:1) Solvents: Dimethylformamide

Reference

Reductive dimerization of aromatic sulfonyl derivatives to disulfides using sodium tellurated borohydride

Suzuki, Hitomi; et al, Journal of Chemical Research, 1994, (2), 70-1

Production Method 30

3248-78-0

822-27-5

Reaction Conditions

1.1 Reagents: Sulfur

Reference

Formation of carbon-carbon and carbon-heteroatom bonds via organoboranes and organoborates

Negishi, Ei-Ichi; et al, Organic Reactions (Hoboken, 1985, 33,

Production Method 31

5813-91-2

822-27-5

Reaction Conditions

Reference

Hydrogenolysis of thioamides with molybdenum sulfide as a catalyst

Konuma, Kenji; et al, Nippon Kagaku Kaishi, 1982, (7), 1187-92

Production Method 32

2690-08-6

822-27-5

Reaction Conditions

Reference

Desulfuration using plasma techniques. III. Reaction to thioethers

Suhr, Harald; et al, Liebigs Annalen der Chemie, 1980, (3), 441-6

Production Method 33

2690-08-6

822-27-5

Reaction Conditions

Reference

Aqueous high-temperature chemistry of carbo- and heterocycles. Part 16. Model sulfur compounds: a study of hydrogen sulfide generation

Katritzky, Alan R.; et al, Energy & Fuels, 1991, 5(6), 823-34

Production Method 34

67038-53-3

822-27-5

Reaction Conditions

Reference

The phase-transfer synthesis of unsymmetrical dialkyl sulfides via O,S-dialkyl dithiocarbonates

Degani, Iacopo; et al, Synthesis, 1979, (3), 178-81

Disulfide, dioctyl Raw materials

• Dioctyl sulfide
• 1-Octanol
• octane-1-sulfonic acid
• Octanethioamide
• Sodium S-octyl sulfurothioate
• 1-Iodooctane
• n-Octyl thiocyanate
• Octane-1-sulfonyl chloride
• 1-Octanesulfonic acid, pentyl ester
• Benzenecarbothioicacid, S-octyl ester
• 1-Bromooctane
• n-Octyl-Xanthate, Potassium Salt
• 1-Octanethiol
• n-Octyl-p-Toluenesulfonate
• Pyridine,4-[2-(octylthio)ethyl]-
• Ethanethioic acid, S-octyl ester
• Borane, trioctyl-
• Carbonodithioic acid, O-methyl S-octyl ester

Disulfide, dioctyl Preparation Products

• Disulfide, dioctyl (822-27-5)

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• 629-45-8(Butyl disulfide)
• 10496-18-1(1,2-Didecyldisulfane)
• 10496-16-9(Disulfide, diheptyl)
• 2500-88-1(1,2-dioctadecyldisulfane)
• 5348-83-4(Disulfide, ditetradecyl)
• 2757-37-1(1-(Dodecyldisulfanyl)dodecane)
• 112-51-6(Diamyl Disulfide)
• 10496-15-8(Di-n-hexyl disulfide)
• 1561-75-7(Disulfide, dihexadecyl)
• 64580-61-6(Disulfide, ethyl octyl)