Production Method 1

90076-65-6

82113-65-3

Reaction Conditions

1.1 Reagents: Sulfuric acid Solvents: Water ;  55 - 60 °C

Reference

Syntheses and lipophilicity measurement of Nα/N-terminus-1,1-dihydroperfluoroalkylated α-amino acids and small peptides

DesMarteau, Darryl D.; et al, Journal of Fluorine Chemistry, 2007, 128(10), 1326-1334

Production Method 2

90076-65-6

82113-65-3

Reaction Conditions

1.1 Reagents: Sulfuric acid Solvents: Water ;  70 °C

Reference

A one-pot synthesis of a ternary nanocomposite based on mesoporous silica, polyaniline and silver

Rosa, Ana Claudia De Abreu; et al, RSC Advances, 2013, 3(48), 26142-26148

Production Method 3

421-85-2

335-05-7

82113-65-3

Reaction Conditions

1.1 -
1.2 Reagents: Sodium methoxide ,  Hexamethyldisilazane
1.3 -

Reference

2,6-Difluorophenylxenon(II) bis(fluorosulfonyl)amide, -bis(trifluoromethylsulfonyl)amide, -tris(fluorosulfonyl)methanide and -bis(trifluoromethylsulfonyl)methanide as new C-Xe-N and C-Xe-C compounds

Yagupolskii, Yurii L.; et al, Journal of Fluorine Chemistry, 2002, 113(2), 143-146

Production Method 4

82113-65-3

82113-65-3

Reaction Conditions

1.1 Reagents: Neodymium sesquioxide Solvents: Water ;  7 h, 90 °C

Reference

Complexation reaction for Ln(III)/TBP in ionic liquid

Li, Rui-rui; et al, Yuanzineng Kexue Jishu, 2017, 51(3), 396-403

Production Method 5

90076-65-6

82113-65-3

Reaction Conditions

1.1 Reagents: Sulfuric acid ;  rt → 90 °C

Reference

Ionic liquid silver salt complexes for propene/propane separation

Agel, Friederike; et al, Physical Chemistry Chemical Physics, 2011, 13(2), 725-731

Production Method 6

91742-21-1

82113-65-3

Reaction Conditions

1.1 Reagents: Sulfuric acid

Reference

N-Fluorobis(trifluoromethanesulfonyl)imide. An improved synthesis

Desmarteau, Darryl D.; et al, Journal of Fluorine Chemistry, 1991, 52(1), 7-12

Production Method 7

91742-21-1

82113-65-3

Reaction Conditions

Reference

Tetrahetero-substituted methanes with a carbon-halogen bond

Il'chenko, A. Y., Science of Synthesis, 2005, 18, 1135-1201

Production Method 8

82113-65-3

82113-65-3

Reaction Conditions

1.1 Solvents: Benzene ;  24 h, rt

Reference

Isolation of a Dicationic Platinum Complex with Two Accessible Coordination Sites

Bowring, Miriam A.; et al, Organometallics, 2013, 32(19), 5266-5268

Production Method 9

82113-65-3

82113-65-3

Reaction Conditions

1.1 Reagents: Titanium Solvents: Water ;  2 d, reflux

Reference

Rational Optimization of Lewis-Acid Catalysts for the Direct Amination of Alcohols, Part 1 - Activity Descriptors for Metal Triflates and Triflimides

Payard, Pierre-Adrien; et al, European Journal of Organic Chemistry, 2020, 2020(22), 3219-3224

Production Method 10

335-05-7

82113-65-3

Reaction Conditions

Reference

Synthesis and structures of alkaline earth metal salts of bis[(trifluoromethyl)sulfonyl]imide

Xue, Lixin; et al, Solid State Sciences, 2005, 7(3), 311-318

Production Method 11

82113-65-3

82113-65-3

Reaction Conditions

1.1 Reagents: Titanium Solvents: Water ;  48 h, reflux

Reference

Rational Optimization of Lewis-Acid Catalysts for Direct Alcohol Amination, Part 2 - Titanium Triflimide as New Active Catalyst

Payard, Pierre-Adrien ; et al, European Journal of Organic Chemistry, 2020, 2020(22), 3225-3228

1,1,1-Trifluoro-N-((trifluoromethyl)sulfonyl)methanesulfonamide Raw materials

• Trifluoromethylsulfonamide
• Methanesulfonylfluoride, trifluoro-
• 1,1,1-Trifluoro-N-((trifluoromethyl)sulfonyl)methanesulfonamide
• Lithium bis(trifluoromethanesulphonyl)imide
• Sodium Bis(Trifluoromethylsulfonyl)Imide

1,1,1-Trifluoro-N-((trifluoromethyl)sulfonyl)methanesulfonamide Preparation Products

• 1,1,1-Trifluoro-N-((trifluoromethyl)sulfonyl)methanesulfonamide (82113-65-3)

• 1. Excellent electrochemical performance of LiFe0.4Mn0.6PO4 microspheres produced using a double carbon coating process?
  Yong Ping Huang,Tao Tao,Zheng Chen,Wei Han,Ying Wu,Chunjiang Kuang,Shaoxiong Zhou,Ying Chen J. Mater. Chem. A, 2014,2, 18831-18837
• 2. Fast synthesis of red Li3BaSrLn3(WO4)8:Eu3+ phosphors for white LEDs under near-UV excitation by a microwave-assisted solid state reaction method and photoluminescence studies
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• 3. Fc microparticles can modulate the physical extent and magnitude of complement activity?
  David White,Sean R. Stowell Biomater. Sci., 2017,5, 463-474
• 4. Emerging investigator series: bacteriophages as nano engineering tools for quality monitoring and pathogen detection in water and wastewater
  Fereshteh Bayat Environ. Sci.: Nano, 2021,8, 367-389
• 5. Establishing empirical design rules of nucleic acid templates for the synthesis of silver nanoclusters with tunable photoluminescence and functionalities towards targeted bioimaging applications?
  Jason Y. C. Lim,Yong Yu,Guorui Jin,Kai Li,Yi Lu,Jianping Xie Nanoscale Adv., 2020,2, 3921-3932

• Solvents and Organic Chemicals Organic Compounds Amines/Sulfonamides

Introduction to 1,1,1-Trifluoro-N-((trifluoromethyl)sulfonyl)methanesulfonamide (CAS No. 82113-65-3)

1,1,1-Trifluoro-N-((trifluoromethyl)sulfonyl)methanesulfonamide, also known by its CAS number 82113-65-3, is a versatile compound with significant applications in the fields of chemistry and pharmaceuticals. This compound is characterized by its unique trifluoromethyl and sulfonyl groups, which confer it with distinct chemical properties and reactivity profiles. In this article, we will delve into the structure, synthesis, properties, and applications of this compound, drawing on the latest research findings to provide a comprehensive overview.

The molecular formula of 1,1,1-Trifluoro-N-((trifluoromethyl)sulfonyl)methanesulfonamide is C₄H₂F₆N₂O₄S₂. The presence of multiple fluorine atoms and sulfonyl groups makes it a highly polar and stable molecule. These characteristics are crucial for its use in various chemical reactions and as an intermediate in the synthesis of more complex compounds.

The synthesis of 1,1,1-Trifluoro-N-((trifluoromethyl)sulfonyl)methanesulfonamide can be achieved through several methods. One common approach involves the reaction of trifluoromethanesulfonyl chloride with trifluoroacetonitrile in the presence of a base. This reaction is typically carried out under controlled conditions to ensure high yields and purity. Recent advancements in synthetic methodologies have led to more efficient and environmentally friendly processes, such as the use of green solvents and catalysts.

In terms of physical properties, 1,1,1-Trifluoro-N-((trifluoromethyl)sulfonyl)methanesulfonamide is a white crystalline solid at room temperature. It has a melting point of approximately 75°C and is soluble in common organic solvents such as dichloromethane and acetonitrile. Its high solubility in organic solvents makes it suitable for use in various chemical reactions and processes.

The chemical reactivity of 1,1,1-Trifluoro-N-((trifluoromethyl)sulfonyl)methanesulfonamide is primarily attributed to its trifluoromethyl and sulfonyl groups. These functional groups can participate in a wide range of reactions, including nucleophilic substitution, electrophilic addition, and elimination reactions. The compound's reactivity has been extensively studied in recent years, leading to its application in the synthesis of novel pharmaceuticals and materials.

In the pharmaceutical industry, 1,1,1-Trifluoro-N-((trifluoromethyl)sulfonyl)methanesulfonamide has gained attention as an intermediate in the synthesis of drugs with improved pharmacological properties. For example, it has been used in the development of fluorinated analogs of existing drugs to enhance their potency and reduce side effects. Recent research has also explored its potential as a building block for the synthesis of new antiviral and anticancer agents.

Beyond pharmaceutical applications, 1,1,1-Trifluoro-N-((trifluoromethyl)sulfonyl)methanesulfonamide has found use in materials science. Its unique chemical structure makes it suitable for the preparation of functional materials with enhanced thermal stability and mechanical strength. For instance, it has been incorporated into polymer matrices to improve their performance in high-temperature applications.

The environmental impact of 1,1,1-Trifluoro-N-((trifluoromethyl)sulfonyl)methanesulfonamide is another important consideration. While it is generally considered stable under normal conditions, proper handling and disposal practices are essential to minimize any potential environmental risks. Recent studies have focused on developing sustainable synthetic routes to reduce the ecological footprint associated with its production.

In conclusion, 1,1,1-Trifluoro-N-((trifluoromethyl)sulfonyl)methanesulfonamide (CAS No. 82113-65-3) is a multifaceted compound with significant applications in chemistry and pharmaceuticals. Its unique chemical structure and reactivity make it an invaluable intermediate in the synthesis of novel drugs and materials. Ongoing research continues to uncover new possibilities for its use, highlighting its importance in both academic and industrial settings.

• 215815-19-3(Methanesulphonyl trifluoromethanesulphonyl imide, lithium salt)
• 176726-07-1(Scandium,tris[1,1,1-trifluoro-N-[(trifluoromethyl)sulfonyl-kO]methanesulfonamidato-kO]-, (OC-6-11)-)
• 647864-13-9(Methanesulfonamide, 1,1,1-trifluoro-N-[(trifluoromethyl)sulfonyl]-, ceriumsalt)
• 90076-65-6(Lithium bis(trifluoromethanesulphonyl)imide)
• 175438-43-4(Ytterbium,tris[1,1,1-trifluoro-N-[(trifluoromethyl)sulfonyl-kO]methanesulfonamidato-kO]-, (OC-6-11)-)
• 223683-79-2(Methanesulphonyl trifluorometanesulphonyl imide, sodium salt)
• 90076-67-8(Methanesulfonamide,1,1,1-trifluoro-N-[(trifluoromethyl)sulfonyl]-, potassium salt (1:1))
• 189114-61-2(Silver Bis(trifluoromethanesulfonyl)imide)
• 189114-86-1(Tris(di(trifluoromethylsulfonyl)imido)yttrium(III))
• 133395-16-1(Magnesium Bis(trifluoromethane Sulfone)imide)