Production Method 1

2117650-80-1

819050-88-9

Reaction Conditions

1.1 Reagents: Hydrogen peroxide Solvents: Methanol ,  Water ;  0 °C; 4 h, 0 °C
1.2 Reagents: Sodium hydroxide Solvents: Water ;  16 h, pH 9 - 10, rt
1.3 Reagents: Hydrochloric acid Solvents: Water ;  pH 1, 0 °C

Reference

Scalable Synthesis of Esp and Rhodium(II) Carboxylates from Acetylacetone and RhCl3·xH2O

Martinez-Castro, Elisa; et al, Organic Process Research & Development, 2020, 24(6), 1207-1212

Production Method 2

69774-36-3

819050-88-9

Reaction Conditions

1.1 Reagents: Potassium hydroxide Solvents: Ethylene glycol ;  12 h, rt → 185 °C
1.2 Reagents: Hydrochloric acid Solvents: Water ;  pH 1

Reference

An efficient method for the synthesis of 2-methyl-1-substituted-phenyl-2-propylamines

Zhu, Lanping; et al, Youji Huaxue, 2018, 38(7), 1695-1702

Production Method 3

819050-88-9

Reaction Conditions

1.1 Reagents: 1,3,5-Benzenetricarboxylic acid ,  Molybdenum(2+), bis[μ-(acetato-κO:κO′)]hexakis(acetonitrile)di-, (Mo-Mo), stereo… ,  Methanesulfonic acid, 1,1,1-trifluoro-, compd. with N,N-dimethylformamide (1:1) Solvents: Dimethylacetamide ;  overnight, 95 °C

Reference

Synthesis, characterization, and polymerization of capped paddlewheel porous cages

Deegan, Meaghan M.; et al, Dalton Transactions, 2021, 50(9), 3127-3131

Production Method 4

626-15-3

819050-88-9

Reaction Conditions

1.1 Reagents: Lithium diisopropylamide Solvents: Tetrahydrofuran ;  20 min, 0 °C
1.2 Solvents: Tetrahydrofuran ;  0 °C; 0 °C → 23 °C; 10 h, 23 °C
1.3 Reagents: Hydrochloric acid Solvents: Water
2.1 Reagents: Potassium hydroxide Solvents: Ethylene glycol ;  12 h, 180 °C

Reference

Observation of a Photogenerated Rh2 Nitrenoid Intermediate in C-H Amination

Das, Anuvab ; et al, Journal of the American Chemical Society, 2018, 140(33), 10412-10415

Production Method 5

626-16-4

819050-88-9

Reaction Conditions

1.1 Reagents: Diisopropylamine ,  Butyllithium Solvents: Tetrahydrofuran ;  -78 °C; 30 min, -78 °C
1.2 1 h, -78 °C
1.3 1 h
1.4 Reagents: Hydrochloric acid Solvents: Water
2.1 Reagents: Potassium hydroxide Solvents: Ethylene glycol ;  12 h, rt → 185 °C
2.2 Reagents: Hydrochloric acid Solvents: Water ;  pH 1

Reference

An efficient method for the synthesis of 2-methyl-1-substituted-phenyl-2-propylamines

Zhu, Lanping; et al, Youji Huaxue, 2018, 38(7), 1695-1702

Production Method 6

626-16-4

819050-88-9

Reaction Conditions

1.1 Reagents: Diisopropylamine ,  Butyllithium Solvents: Tetrahydrofuran ,  Hexane ,  Water ;  -78 °C; 60 min, -78 °C
1.2 Solvents: Tetrahydrofuran ;  10 min, rt
1.3 Reagents: Water ;  rt
2.1 Reagents: Potassium hydroxide Solvents: Ethylene glycol ;  9 h, 180 °C; 180 °C → rt
2.2 Reagents: Hydrochloric acid Solvents: Water ;  rt

Reference

Cobalt complexes of the chelating dicarboxylate ligand "esp": a paddlewheel-type dimer and a heptanuclear coordination cluster

Pakula, Ryan J.; et al, Dalton Transactions, 2018, 47(39), 13887-13893

Production Method 7

69774-36-3

819050-88-9

Reaction Conditions

1.1 Reagents: Potassium hydroxide Solvents: Ethylene glycol ;  9 h, 180 °C; 180 °C → rt
1.2 Reagents: Hydrochloric acid Solvents: Water ;  rt

Reference

Cobalt complexes of the chelating dicarboxylate ligand "esp": a paddlewheel-type dimer and a heptanuclear coordination cluster

Pakula, Ryan J.; et al, Dalton Transactions, 2018, 47(39), 13887-13893

Production Method 8

69774-36-3

819050-88-9

Reaction Conditions

1.1 Reagents: Potassium hydroxide Solvents: Ethylene glycol ;  12 h, 180 °C

Reference

Observation of a Photogenerated Rh2 Nitrenoid Intermediate in C-H Amination

Das, Anuvab ; et al, Journal of the American Chemical Society, 2018, 140(33), 10412-10415

Production Method 9

626-16-4

819050-88-9

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Methyl ethyl ketone ;  5 min, rt
1.2 6 h, 60 °C; 60 °C → rt
1.3 Reagents: Potassium carbonate Solvents: 1,2-Dimethoxyethane ;  rt → 85 °C; 17 h, 85 °C
2.1 Reagents: Hydrogen peroxide Solvents: Methanol ,  Water ;  0 °C; 4 h, 0 °C
2.2 Reagents: Sodium hydroxide Solvents: Water ;  16 h, pH 9 - 10, rt
2.3 Reagents: Hydrochloric acid Solvents: Water ;  pH 1, 0 °C

Reference

Scalable Synthesis of Esp and Rhodium(II) Carboxylates from Acetylacetone and RhCl3·xH2O

Martinez-Castro, Elisa; et al, Organic Process Research & Development, 2020, 24(6), 1207-1212

Production Method 10

626-15-3

819050-88-9

Reaction Conditions

1.1 Reagents: Lithium diisopropylamide Solvents: Tetrahydrofuran ;  10 min, 0 °C
1.2 Solvents: Tetrahydrofuran ;  20 min, 0 °C
1.3 Reagents: Hydrochloric acid Solvents: Water
2.1 Reagents: Potassium hydroxide Solvents: Ethylene glycol ;  rt → 180 °C; 6 h, 180 °C; 180 °C → rt
2.2 Reagents: Hydrochloric acid Solvents: Chloroform ,  Water ;  pH 1, rt

Reference

Bimetallic reductive elimination from dinuclear Pd(III) complexes

Powers, David C.; et al, Journal of the American Chemical Society, 2010, 132(40), 14092-14103

Production Method 11

626-15-3

819050-88-9

Reaction Conditions

1.1 Reagents: Lithium diisopropylamide Solvents: Tetrahydrofuran ;  10 min, 0 °C
1.2 Solvents: Tetrahydrofuran ;  20 min, 0 °C
1.3 Reagents: Hydrochloric acid Solvents: Water
2.1 Reagents: Potassium hydroxide Solvents: Ethylene glycol ;  rt → 180 °C; 6 h, 180 °C; 180 °C → rt
2.2 Reagents: Hydrochloric acid Solvents: Chloroform ,  Water ;  pH 1, rt

Reference

Bimetallic Pd(III) complexes in palladium-catalysed carbon-heteroatom bond formation

Powers, David C.; et al, Nature Chemistry, 2009, 1(4), 302-309

Production Method 12

626-16-4

819050-88-9

Reaction Conditions

1.1 Reagents: Lithium diisopropylamide
1.2 5 min
2.1 Reagents: Potassium hydroxide Solvents: Ethylene glycol

Reference

Introducing a mixed-valent dirhodium(II,III) catalyst with increased stability in C-H amination

Kornecki, Katherine P.; et al, Chemical Communications (Cambridge, 2012, 48(99), 12097-12099

alpha,alpha,alpha',alpha'-Tetramethyl-1,3-benzenedipropionic acid Raw materials

• alpha,alpha,alpha',alpha'-Tetramethyl-1,3-benzenedipropionitrile
• 2,4-Pentanedione, 3,3'-[(1,3-phenylene)bis(methylene)]bis[3-methyl-
• 1,3-Bis(bromomethyl)benzene
• m-Xylene Dichloride

alpha,alpha,alpha',alpha'-Tetramethyl-1,3-benzenedipropionic acid Preparation Products

• alpha,alpha,alpha',alpha'-Tetramethyl-1,3-benzenedipropionic acid (819050-88-9)

• 1. An apparatus for determining small amounts of alchohol in sour milk and urine
  Analyst, 1964,89, 272-275
• 2. An Assessment of the Laminar Hypersonic Double-Cone Experiments in the LENS-XX Tunnel
  JaideepRay,PatrickBlonigan,EricT.Phipps,KathrynMaupin
• 3. An artificial photosynthesis system comprising a covalent triazine framework as an electron relay facilitator for photochemical carbon dioxide reduction?
  Siquan Zhang,Shengyao Wang,Liping Guo,Hao Chen,Bien Tan,Shangbin Jin J. Mater. Chem. C, 2020,8, 192-200
• 4. An integrated microfluidic platform for sensitive and rapid detection of biological toxins?
  Robert J. Meagher,Anson V. Hatch,Ronald F. Renzi,Anup K. Singh Lab Chip, 2008,8, 2046-2053
• 5. An atomistic mechanism for the degradation of perovskite solar cells by trapped charge?
  Eunhak Lim,Jiyoung Heo,Seong Keun Kim Nanoscale, 2019,11, 11369-11378

Alpha,Alpha,Alpha',Alpha'-Tetramethyl-1,3-Benzenedipropionic Acid: A Comprehensive Overview

Alpha,Alpha,Alpha',Alpha'-Tetramethyl-1,3-Benzenedipropionic Acid (CAS No. 819050-88-9) is a compound of significant interest in the fields of organic chemistry and materials science. This compound is characterized by its unique structure, which combines a benzene ring with two propionic acid groups and four methyl substituents. The benzenedipropionic acid framework provides a versatile platform for various chemical modifications, making it a valuable component in the synthesis of advanced materials and functional molecules.

Recent studies have highlighted the potential of alpha,alpha,alpha',alpha'-tetramethyl-1,3-benzenedipropionic acid in the development of high-performance polymers. Researchers have explored its ability to form cross-linked networks with enhanced mechanical and thermal properties. These findings suggest that the compound could be utilized in applications such as lightweight composites for aerospace and automotive industries. The benzenedipropionic acid moiety plays a crucial role in these applications due to its ability to participate in both covalent and non-covalent interactions.

In addition to its role in polymer science, alpha,alpha,alpha',alpha'-tetramethyl-1,3-benzenedipropionic acid has shown promise in the field of biochemistry. Its methyl-substituted structure enhances its lipophilicity, making it an attractive candidate for drug delivery systems. Recent experiments have demonstrated that derivatives of this compound can serve as effective carriers for hydrophobic drugs, improving their solubility and bioavailability. This property is particularly valuable in the development of targeted therapies for chronic diseases.

The synthesis of alpha,alpha,alpha',alpha'-tetramethyl-1,3-benzenedipropionic acid involves a multi-step process that typically begins with the preparation of the benzene ring derivative. The introduction of the propionic acid groups is achieved through esterification or direct alkylation techniques. The methyl substituents are introduced at specific positions to ensure optimal chemical reactivity and stability. Advanced spectroscopic techniques such as NMR and IR are employed to confirm the structure and purity of the final product.

From an environmental perspective, the compound's stability and biodegradability are critical factors. Recent studies have investigated its environmental impact under various conditions, including aqueous solutions and soil environments. Results indicate that alpha,alpha,alpha',alpha'-tetramethyl-1,3-benzenedipropionic acid exhibits moderate biodegradability under aerobic conditions, suggesting that it could be incorporated into sustainable chemical processes with proper waste management practices.

Looking ahead, the potential applications of alpha,alpha,alpha',alpha'-tetramethyl-1,3-benzenedipropionic acid are expected to expand further as researchers continue to explore its unique properties. Its ability to function as both a building block for advanced materials and a component in biochemical systems positions it as a versatile compound with wide-ranging utility. As industries increasingly prioritize innovation and sustainability, this compound is poised to play a pivotal role in shaping future technologies.

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• 27771-09-1((2R)-2-Benzyl-2,3-dimethylbutanoic acid)
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