Cas no 81846-19-7 (Treprostinil)

Treprostinil structure
Treprostinil structure
Product Name:Treprostinil
CAS No:81846-19-7
MF:C23H34O5
MW:390.513067722321
MDL:MFCD00888847
CID:723210
PubChem ID:6918140
Update Time:2024-10-27

Treprostinil Chemical and Physical Properties

Names and Identifiers

    • Treprostinil
    • 2-[[(1R,2R,3aS,9aS)-2-hydroxy-1-[(3S)-3-hydroxyoctyl]-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[g]naphthalen-5-yl]oxy]acetic acid
    • REMODULIN
    • UNIPROST
    • [14C]-Treprostinil
    • 15AU81
    • 2-((1R,2R,3aS,9aS)-2,3,3a,4,9,9a-hexahydro-2-hydroxy-1-((S)-3-hydroxyoctyl)-1H-cyclopenta[b]naphthalen-5-yloxy)acetic acid
    • LCZ696
    • LCZ-696
    • LRX-15
    • sacubitril
    • treprostinol
    • Tyvaso
    • UNII-RUM6K67ESG
    • Valsartan
    • 2-[[(1R,2R,3aS,9aS)-2,3,4,9,9a-hexahydro-2-hydroxy-1-[(3S)-3-hydroxyoctyl]-1H-benz[f]inden-5-yl]oxy]-acetic acid
    • [[(1R,2R,3aS,9aS)-2,3,3a,4,9,9a-Hexahydro-2-hydroxy-1-[(3S)-3-hydroxyoctyl]-1H-benz[f]inden-5-yl]oxy]acetic acid
    • 1H-Benz[f]indene, acetic acid deriv. (ZCI)
    • 2-[[(1R,2R,3aS,9aS)-2,3,3a,4,9,9a-Hexahydro-2-hydroxy-1-[(3S)-3-hydroxyoctyl]-1H-benz[f]inden-5-yl]oxy]acetic acid (ACI)
    • Acetic acid, [[(1R,2R,3aS,9aS)-2,3,3a,4,9,9a-hexahydro-2-hydroxy-1-[(3S)-3-hydroxyoctyl]-1H-benz[f]inden-5-yl]oxy]- (9CI)
    • Acetic acid, [[2,3,3a,4,9,9a-hexahydro-2-hydroxy-1-(3-hydroxyoctyl)-1H-benz[f]inden-5-yl]oxy]-, [1R-[1α(S*),2β,3aα,9aα]]- (ZCI)
    • 2-[[(1R,2R,3aS,9aS)-2-Hydroxy-1-((S)-3-hydroxyoctyl)-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalen-5-yl]oxy]acetic acid
    • BW 15AU
    • LRX 15
    • Rumodolin
    • Trevyent
    • U 62840
    • MDL： MFCD00888847
    • Inchi： 1S/C23H34O5/c1-2-3-4-7-17(24)9-10-18-19-11-15-6-5-8-22(28-14-23(26)27)20(15)12-16(19)13-21(18)25/h5-6,8,16-19,21,24-25H,2-4,7,9-14H2,1H3,(H,26,27)/t16-,17-,18+,19-,21+/m0/s1
    • InChI Key： PAJMKGZZBBTTOY-ZFORQUDYSA-N
    • SMILES： C([C@H]1[C@H](O)C[C@@H]2CC3C(OCC(=O)O)=CC=CC=3C[C@H]12)C[C@@H](O)CCCCC

Computed Properties

  • Exact Mass: 412.22300

Experimental Properties

  • Melting Point: 121-123°
  • PSA: 89.82000
  • LogP: 2.24850
  • Optical Activity: [α]/D 40 to 50°, c =?0.5 in methanol

Treprostinil Security Information

  • Hazardous Material transportation number：NONH for all modes of transport
  • Storage Condition：Powder -20°C 3 years In solvent -80°C 6 months ? -20°C 1 month

Treprostinil Pricemore >>

Related Categories No. Product Name Cas No. Purity Specification Price update time Inquiry
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 81846-19-7 98%
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CHENG DOU FEI BO YI YAO Technology Co., Ltd.
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2-[[(1r,2r,3as,9as)-2-hydroxy-1-[(3s)-3-hydroxyoctyl]-2,3,3a,4,9,9a-hexahydro-1h-cyclopenta[g]naphthalen-5-yl]oxy]acetic Acid
 81846-19-7 95%
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SHANG HAI TAO SHU Biotechnology Co., Ltd.
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 81846-19-7 99.71%
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 ￥759.00 2022-04-26
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 81846-19-7 99.71%
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 81846-19-7 99.71%
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SHANG HAI TAO SHU Biotechnology Co., Ltd.
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 81846-19-7 99.71%
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ChemScence
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Treprostinil
 81846-19-7 99.98%
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 $50.0 2022-04-26
ChemScence
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 81846-19-7 99.98%
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 $90.0 2022-04-26
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 81846-19-7 99.98%
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Treprostinil Production Method

Production Method 1

Reaction Conditions
1.1 Reagents: Sodium hydroxide Solvents: Methanol ,  Water ;  55 - 60 °C; 60 °C → 45 °C
1.2 Reagents: Hydrochloric acid Solvents: Water ;  40 - 45 °C
Reference
Process for preparation of prostacyclin derivative
Anonymous, IP.com Journal, 2017, 17, 1-5

Production Method 2

Reaction Conditions
1.1 Reagents: Tetrabutylammonium iodide ,  Potassium carbonate
1.2 Reagents: Potassium hydroxide
Reference
Synthetic routes to treprostinil N-acyl methylsulfonamide
Picken, Christina; et al, Tetrahedron Letters, 2020, 61(5),

Production Method 3

Reaction Conditions
1.1 Reagents: Sodium hydroxide Solvents: Ethanol ,  Water ;  30 min, -10 °C
1.2 Reagents: Sodium borohydride ;  1 h, -10 °C; 12 h, 0 °C
1.3 Reagents: Acetic acid ;  pH 2 - 3
1.4 Reagents: Hydrofluoric acid, homopolymer, compd. with pyridine Solvents: Tetrahydrofuran ;  0 °C; 0 °C → rt; 15 h, rt
1.5 Reagents: Sodium bicarbonate Solvents: Water ;  basified, rt
Reference
Synthesis of treprostinil: key Claisen rearrangement and catalytic Pauson-Khand reactions in continuous flow
Garcia-Lacuna, Jorge; et al, Organic & Biomolecular Chemistry, 2019, 17(43), 9489-9501

Production Method 4

Reaction Conditions
1.1 Reagents: Hydrofluoric acid, homopolymer, compd. with pyridine Solvents: Tetrahydrofuran ;  0 °C; 0 °C → rt; 15 h, rt
1.2 Reagents: Sodium bicarbonate Solvents: Water ;  basified, rt
Reference
Synthesis of treprostinil: key Claisen rearrangement and catalytic Pauson-Khand reactions in continuous flow
Garcia-Lacuna, Jorge; et al, Organic & Biomolecular Chemistry, 2019, 17(43), 9489-9501

Treprostinil Raw materials

Treprostinil Preparation Products

Treprostinil Suppliers

Amadis Chemical Company Limited
Gold Member
Audited Supplier Audited Supplier
(CAS:81846-19-7)Treprostinil
Order Number:A897799
Stock Status:in Stock
Quantity:250mg/100mg/50mg
Purity:99%
Pricing Information Last Updated:Friday, 30 August 2024 12:00
Price ($):405.0/243.0/164.0
Tiancheng Chemical (Jiangsu) Co., Ltd
Gold Member
Audited Supplier Audited Supplier
(CAS:81846-19-7)瑞莫杜林
Order Number:LE26864494
Stock Status:in Stock
Quantity:25KG,200KG,1000KG
Purity:99%
Pricing Information Last Updated:Friday, 20 June 2025 12:59
Price ($):discuss personally

Treprostinil Related Literature

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81846-19-7 (Treprostinil) Related Products

Recommended suppliers
Amadis Chemical Company Limited
(CAS:81846-19-7)Treprostinil
A897799
Purity:99%/99%/99%
Quantity:250mg/100mg/50mg
Price ($):405.0/243.0/164.0
Email
Tiancheng Chemical (Jiangsu) Co., Ltd
(CAS:81846-19-7)瑞莫杜林
LE26864494
Purity:99%
Quantity:25KG,200KG,1000KG
Price ($):Inquiry
Email