Production Method 1

81759-25-3

Reaction Conditions

1.1 Reagents: Selenium ;  2 h, 0.1 MPa, 20 °C
1.2 Reagents: Oxygen ;  1 h, 0.1 MPa, 20 °C

Reference

Efficient solvent-free synthesis of urea derivatives using selenium-catalyzed carbonylation of amines with carbon monoxide and oxygen

Mizuno, Takumi; Nakai, Takeo; Mihara, Masatoshi, Synthesis, 2010, (24), 4251-4255

Production Method 2

1192-63-8

81759-25-3

Reaction Conditions

1.1 Reagents: Triethylamine Solvents: Dichloromethane ;  12 h, rt

Reference

Iridium-Catalyzed Enantioselective α-C(sp3)-H Borylation of Azacycles

Chen, Lili; Yang, Yuhuan; Liu, Luhua; Gao, Qian; Xu, Senmiao, Journal of the American Chemical Society, 2020, 142(28), 12062-12068

Production Method 3

81759-25-3

Reaction Conditions

1.1 Reagents: Oxygen Catalysts: 2242829-68-9 Solvents: Toluene ;  30 h, 1.6 MPa, 60 °C

Reference

Amine-Responsive Disassembly of AuI-CuI Double Salts for Oxidative Carbonylation

Cao, Yanwei; Yang, Jian-Gong; Deng, Yi; Wang, Shengchun; Liu, Qi; et al, Angewandte Chemie, 2020, 59(5), 2080-2084

Production Method 4

81759-25-3

Reaction Conditions

1.1 Reagents: Potassium carbonate ,  Iodine Catalysts: Tungsten hexacarbonyl Solvents: Dichloromethane

Reference

Catalytic oxidative carbonylation of aliphatic secondary amines to tetrasubstituted ureas

McCusker, J. E.; Qian, F.; McElwee-White, L., Journal of Molecular Catalysis A: Chemical, 2000, 159(1), 11-17

Production Method 5

433302-49-9

81759-25-3

Reaction Conditions

1.1 Reagents: Triethylamine Solvents: Dichloromethane ;  24 h, rt

Reference

Achieving functional group diversity in parallel synthesis: solution-phase synthesis of a library of ureas, carbamates, thiocarbamates, and amides using carbamoylimidazolium salts

Grzyb, Justyna A.; Batey, Robert A., Tetrahedron Letters, 2008, 49(36), 5279-5282

Production Method 6

81759-25-3

Reaction Conditions

1.1 Solvents: 1,4-Dioxane ;  20 - 30 min, rt
1.2 Reagents: Trichloroisocyanuric acid ,  Triphenylphosphine Solvents: 1,4-Dioxane ;  0 °C; 5.5 h, 0 °C → 80 °C

Reference

A high-yielding, expeditious, and multicomponent synthesis of urea and carbamate derivatives by using triphenylphosphine/trichloroisocyanuric acid system

Ghodsinia, Sara S. E.; Akhlaghinia, Batool, Phosphorus, 2016, 191(1), 1-7

Production Method 7

81759-25-3

Reaction Conditions

1.1 Solvents: Dimethyl sulfoxide ;  30 min, rt
1.2 Reagents: Triphenylphosphine ,  Diethyl azodicarboxylate ;  rt
1.3 4 h, rt

Reference

A high yielding, one-pot synthesis of substituted ureas from the corresponding amines using Mitsunobu's reagent

Chaturvedi, Devdutt; Mishra, Nisha; Mishra, Virendra, Monatshefte fuer Chemie, 2008, 139(3), 267-270

Production Method 8

81759-25-3

Reaction Conditions

1.1 Reagents: Triethylamine Solvents: Tetrahydrofuran

Reference

Synthetic studies towards ristocetin A and related compounds using arene-ruthenium chemistry

Lee, Kieseung, 1996, , 56(11),

Di(pyrrolidin-1-yl)methanone Raw materials

• 3-Methyl-1-(pyrrolidine-1-carbonyl)-1H-imidazol-3-ium Iodide
• pyrrolidine-1-carbonyl chloride

Di(pyrrolidin-1-yl)methanone Preparation Products

• Di(pyrrolidin-1-yl)methanone (81759-25-3)

• 1. Fast-pulsing NMR techniques for the detection of weak interactions: successful natural abundance probe of hydrogen bonds in peptides?
  Amandine Altmayer-Henzien,Valérie Declerck,David J. Aitken,Ewen Lescop,Denis Merlet,Jonathan Farjon Org. Biomol. Chem., 2013,11, 7611-7615
• 2. Excimer emission and magnetoluminescence of radical-based zinc(ii) complexes doped in host crystals?
  Shojiro Kimura,Tetsuro Kusamoto Chem. Commun., 2020,56, 11195-11198
• 3. Dissolution of cork biopolymers in biocompatible ionic liquids
  Helga Garcia,Rui Ferreira,Marija Petkovic,Jamie L. Ferguson,Maria C. Leit?o,H. Q. Nimal Gunaratne,Luís Paulo N. Rebelo Green Chem., 2010,12, 367-369
• 4. Evolution of hierarchical porous structures in supramolecular guest–host hydrogels?
  Christopher B. Rodell,Christopher B. Highley,Minna H. Chen,Neville N. Dusaj,Chao Wang,Lin Han,Jason A. Burdick Soft Matter, 2016,12, 7839-7847
• 5. Excitonic and vibrational coherence in artificial photosynthetic systems studied by negative-time ultrafast laser spectroscopy
  Dongjia Han,Bing Xue,Juan Du,Tomohiro Miyatake,Hitoshi Tamiaki,Xin Xing,Wei Yuan,Yanyan Li Phys. Chem. Chem. Phys., 2016,18, 24252-24260

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyrrolidines Pyrrolidinecarboxamides
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyrrolidines Pyrrolidine carboxylic acids and derivatives Pyrrolidinecarboxamides
• Other Chemical additives Process Aids

• 89913-92-8(2H-1,3-Diazepin-2-one, 1,3-dibutylhexahydro-)
• 89913-90-6(2H-1,3-Diazepin-2-one, hexahydro-1,3-dipropyl-)
• 409314-87-0(1-Pyrrolidinecarboxamide,N,N-dimethyl-)
• 31563-40-3(Urea,N,N''-1,6-hexanediylbis[N',N'-diethyl- (9CI))
• 62508-42-3(Urea, N,N'-dibutyl-N,N'-diethyl-)
• 78382-95-3(2H-1,3-Diazepin-2-one, 1,3-diethylhexahydro-)
• 25991-86-0(1H-Azepine,1,1'-carbonylbis[hexahydro- (8CI,9CI))
• 348594-03-6(N-propylpyrrolidine-1-carboxamide)
• 4559-86-8(N,N,N',N'-Tetra-N-butylurea)
• 89913-91-7(2H-1,3-Diazepin-2-one, hexahydro-1,3-bis(1-methylethyl)-)