Production Method 1

81608-30-2

Reaction Conditions

1.1 Reagents: Thioanisole ,  m-Cresol ,  Trifluoromethanesulfonic acid ,  Ethanedithiol Solvents: Trifluoroacetic acid
1.2 Reagents: Ammonium hydroxide ,  Dithiothreitol Solvents: Methanol ,  Water

Reference

Studies on peptides. CXXIX. Application of Nin-mesitylenesulfonyltryptophan for the syntheses of neuromedin B and neuromedin C

Fujii, Nobutaka; et al, Chemical & Pharmaceutical Bulletin, 1985, 33(9), 3731-7

Production Method 2

100642-69-1

100642-71-5

81608-30-2

Reaction Conditions

1.1 Reagents: Trifluoroacetic acid
1.2 Reagents: Triethylamine Solvents: Dimethylformamide
2.1 Reagents: Thioanisole ,  m-Cresol ,  Trifluoromethanesulfonic acid ,  Ethanedithiol Solvents: Trifluoroacetic acid
2.2 Reagents: Ammonium hydroxide ,  Dithiothreitol Solvents: Methanol ,  Water

Reference

Studies on peptides. CXXIX. Application of Nin-mesitylenesulfonyltryptophan for the syntheses of neuromedin B and neuromedin C

Fujii, Nobutaka; et al, Chemical & Pharmaceutical Bulletin, 1985, 33(9), 3731-7

Production Method 3

100642-67-9

51165-13-0

81608-30-2

Reaction Conditions

1.1 Reagents: Trifluoroacetic acid
1.2 Reagents: Triethylamine Solvents: Dimethylformamide
2.1 Reagents: Hydrazine Solvents: Dimethylformamide
3.1 Reagents: Trifluoroacetic acid
3.2 Reagents: Triethylamine Solvents: Dimethylformamide
4.1 Reagents: Thioanisole ,  m-Cresol ,  Trifluoromethanesulfonic acid ,  Ethanedithiol Solvents: Trifluoroacetic acid
4.2 Reagents: Ammonium hydroxide ,  Dithiothreitol Solvents: Methanol ,  Water

Reference

Studies on peptides. CXXIX. Application of Nin-mesitylenesulfonyltryptophan for the syntheses of neuromedin B and neuromedin C

Fujii, Nobutaka; et al, Chemical & Pharmaceutical Bulletin, 1985, 33(9), 3731-7

Production Method 4

100642-68-0

81608-30-2

Reaction Conditions

1.1 Reagents: Hydrazine Solvents: Dimethylformamide
2.1 Reagents: Trifluoroacetic acid
2.2 Reagents: Triethylamine Solvents: Dimethylformamide
3.1 Reagents: Thioanisole ,  m-Cresol ,  Trifluoromethanesulfonic acid ,  Ethanedithiol Solvents: Trifluoroacetic acid
3.2 Reagents: Ammonium hydroxide ,  Dithiothreitol Solvents: Methanol ,  Water

Reference

Studies on peptides. CXXIX. Application of Nin-mesitylenesulfonyltryptophan for the syntheses of neuromedin B and neuromedin C

Fujii, Nobutaka; et al, Chemical & Pharmaceutical Bulletin, 1985, 33(9), 3731-7

Production Method 5

100642-70-4

81608-30-2

Reaction Conditions

1.1 Reagents: Trifluoroacetic acid
1.2 Reagents: Triethylamine Solvents: Dimethylformamide
2.1 Reagents: Trifluoroacetic acid
2.2 Reagents: Triethylamine Solvents: Dimethylformamide
3.1 Reagents: Thioanisole ,  m-Cresol ,  Trifluoromethanesulfonic acid ,  Ethanedithiol Solvents: Trifluoroacetic acid
3.2 Reagents: Ammonium hydroxide ,  Dithiothreitol Solvents: Methanol ,  Water

Reference

Studies on peptides. CXXIX. Application of Nin-mesitylenesulfonyltryptophan for the syntheses of neuromedin B and neuromedin C

Fujii, Nobutaka; et al, Chemical & Pharmaceutical Bulletin, 1985, 33(9), 3731-7

Production Method 6

23931-69-3

1499-46-3

81608-30-2

Reaction Conditions

1.1 Solvents: Dimethylformamide
2.1 Reagents: Trifluoroacetic acid
2.2 Reagents: Triethylamine Solvents: Dimethylformamide
3.1 Reagents: Hydrazine Solvents: Dimethylformamide
4.1 Reagents: Trifluoroacetic acid
4.2 Reagents: Triethylamine Solvents: Dimethylformamide
5.1 Reagents: Thioanisole ,  m-Cresol ,  Trifluoromethanesulfonic acid ,  Ethanedithiol Solvents: Trifluoroacetic acid
5.2 Reagents: Ammonium hydroxide ,  Dithiothreitol Solvents: Methanol ,  Water

Reference

Studies on peptides. CXXIX. Application of Nin-mesitylenesulfonyltryptophan for the syntheses of neuromedin B and neuromedin C

Fujii, Nobutaka; et al, Chemical & Pharmaceutical Bulletin, 1985, 33(9), 3731-7

Neuromedin C (swinespinal cord) (9CI) Raw materials

• L-Histidine, N-[N2-[N-[[(4-methoxyphenyl)methoxy]carbonyl]glycyl]-L-asparaginyl]-, hydrazide (9CI)
• L-Histidine, N-[N2-[[(4-methoxyphenyl)methoxy]carbonyl]-L-asparaginyl]-, methyl ester (9CI)
• L-Asparagine, N2-[[(4-methoxyphenyl)methoxy]carbonyl]-, 4-nitrophenyl ester
• Butanamide, N-[(1,1-dimethylethoxy)carbonyl]-1-[(2,4,6-trimethylphenyl)sulfonyl]-L-tryptophyl-L-alanyl-L-valylglycyl-L-histidyl-L-leucyl-4-(methylsulfinyl)-L-2-amino- (9CI)
• methyl (2S)-2-amino-3-(1H-imidazol-4-yl)propanoate
• Glycine, N-[[(4-methoxyphenyl)methoxy]carbonyl]-, 4-nitrophenyl ester
• L-Histidine, N-[N2-[N-[[(4-methoxyphenyl)methoxy]carbonyl]glycyl]-L-asparaginyl]-, methyl ester
• Carbamic acid, [2-[(2,5-dioxo-1-pyrrolidinyl)oxy]-2-oxo-1-[[1-[(2,4,6-trimethylphenyl)sulfonyl]-1H-indol-3-yl]methyl]ethyl]-, 1,1-dimethylethyl ester, (S)- (9CI)

Neuromedin C (swinespinal cord) (9CI) Preparation Products

• Neuromedin C (swinespinal cord) (9CI) (81608-30-2)

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• Solvents and Organic Chemicals Organic Compounds Organic Polymers Polypeptides Polypeptides
• Solvents and Organic Chemicals Organic Compounds Organic Polymers Polypeptides
• Other Chemical Reagents

Comprehensive Overview of Neuromedin C (swine spinal cord) (9CI) (CAS No. 81608-30-2)

Neuromedin C (swine spinal cord) (9CI) is a bioactive peptide that has garnered significant attention in neuroscience and biomedical research. With the CAS number 81608-30-2, this compound is part of the neuromedin family, which plays crucial roles in various physiological processes. Researchers are particularly interested in its potential applications in neurobiology, pain management, and gastrointestinal regulation.

The swine spinal cord-derived Neuromedin C is known for its high specificity and biological activity. Recent studies have explored its interaction with G-protein-coupled receptors (GPCRs), making it a valuable tool for understanding neural signaling pathways. The growing interest in peptide-based therapeutics has further highlighted the importance of this compound in drug discovery and development.

One of the most searched questions about Neuromedin C is its role in neurodegenerative diseases. With the increasing prevalence of conditions like Alzheimer's and Parkinson's, researchers are investigating how neuromedin peptides might influence disease progression. Preliminary studies suggest that Neuromedin C (swine spinal cord) could modulate neuroinflammatory responses, offering potential therapeutic avenues.

Another hot topic in the scientific community is the use of Neuromedin C in gut-brain axis research. The compound's effects on gastrointestinal motility and secretion have made it a subject of interest for treating functional gut disorders. This aligns with the rising trend of exploring the microbiome's impact on neurological health, a frequently searched topic in both academic and public domains.

From a technical perspective, CAS 81608-30-2 represents a well-characterized peptide with established protocols for extraction and purification. Its stability and solubility profiles make it suitable for various experimental setups, including in vitro and in vivo studies. The compound's molecular weight and amino acid sequence are frequently queried by researchers, emphasizing the need for accurate, detailed information in scientific databases.

The market for Neuromedin C-related research tools has expanded significantly, driven by the demand for high-purity peptides in academic and pharmaceutical labs. Companies specializing in peptide synthesis often list this compound among their top-selling products, reflecting its importance in contemporary neuroscience research.

Recent advancements in peptide engineering have opened new possibilities for modifying Neuromedin C (swine spinal cord) to enhance its stability or receptor specificity. Such innovations are particularly relevant in the context of developing peptide-based drugs with improved pharmacokinetic properties - a trending topic in medicinal chemistry circles.

Quality control remains paramount when working with Neuromedin C (9CI). Researchers frequently search for information on proper storage conditions (-20°C lyophilized) and handling procedures to maintain the compound's integrity. These practical considerations are crucial for obtaining reproducible results in experimental settings.

The structural characteristics of Neuromedin C, including its disulfide bridges and post-translational modifications, make it an interesting case study in peptide biochemistry. These features contribute to its biological activity and receptor binding properties - aspects that are often explored in graduate-level biochemistry courses and professional development seminars.

Looking forward, the scientific community anticipates more discoveries about Neuromedin C (swine spinal cord) and its potential clinical applications. With increasing interest in personalized medicine and targeted therapies, this peptide may play a significant role in future treatment strategies for neurological and gastrointestinal disorders.

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