Production Method 1

534-07-6

816-39-7

Reaction Conditions

1.1 Reagents: Lithium bromide Solvents: Acetone

Reference

Two new amphiphilic catalysts for ester hydrolysis

Menger, F. M.; et al, Journal of Organic Chemistry, 1987, 52(15), 3451-2

Production Method 2

22094-18-4

816-39-7

Reaction Conditions

1.1 Reagents: Sulfuric acid Solvents: Water ;  48 h, 50 °C

Reference

Highly sensitive profiling assay of acidic plant hormones using a novel mass probe by capillary electrophoresis-time of flight-mass spectrometry

Chen, Ming-Luan; et al, Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 2011, 879(13-14), 938-944

Production Method 3

22094-18-4

816-39-7

Reaction Conditions

1.1 Reagents: Sulfuric acid Solvents: Water ;  48 h, 60 °C

Reference

Use of isotope differential derivatization for simultaneous determination of thiols and oxidized thiols by liquid chromatography tandem mass spectrometry

Huang, Yun-Qing; et al, Analytical Biochemistry, 2011, 416(2), 159-166

Production Method 4

96-21-9

816-39-7

Reaction Conditions

1.1 Reagents: Periodic acid (H5IO6) Solvents: Acetonitrile ;  3 h, rt

Reference

Expeditious syntheses to pharmochemicals 1,3-dihydroxyacetone, 1,3-dichloro-, 1,3-dibromo- and 1,3-diiodoacetone from glycerol 1,3-dichlorohydrin using homogenous and heterogenous medium

da Silva, Fernanda Priscila N. R.; et al, Journal of the Brazilian Chemical Society, 2020, 31(8), 1725-1731

Production Method 5

96-21-9

816-39-7

Reaction Conditions

1.1 Reagents: Hydrogen peroxide Catalysts: 2728031-85-2 Solvents: Acetonitrile ,  Water ;  24 h, 80 °C

Reference

Bio-derived nanosilica-anchored Cu(II)-organoselenium complex as an efficient retrievable catalyst for alcohol oxidation

Gogoi, Rajjyoti ; et al, Applied Organometallic Chemistry, 2021, 35(12),

Production Method 6

816-39-7

Reaction Conditions

1.1 Catalysts: Chloroperoxidase

Reference

Novel haloperoxidase substrates. Alkynes and cyclopropanes

Geigert, John; et al, Journal of Biological Chemistry, 1983, 258(4), 2273-7

Production Method 7

816-39-7

Reaction Conditions

1.1 Reagents: Bromine Solvents: Methanol ;  rt; 2 h, rt; overnight, -18 °C
2.1 Reagents: Sulfuric acid Solvents: Water ;  rt; 48 h, 50 °C

Reference

Use of isotope mass probes for metabolic analysis of the jasmonate biosynthetic pathway

Huang, Yun-Qing; et al, Analyst (Cambridge, 2011, 136(7), 1515-1522

Production Method 8

816-39-7

867-54-9

Reaction Conditions

1.1 Reagents: Hydrogen tribromide, compd. with N,N-dimethylacetamide (1:2) Solvents: Methanol

Reference

Selective monobromination of ketones by bis(dimethylacetamide)hydrogen tribromide

Rodygin, M. Yu.; et al, Zhurnal Organicheskoi Khimii, 1994, 30(6), 827-32

Production Method 9

816-39-7

867-54-9

Reaction Conditions

1.1 Reagents: Hydrogen tribromide, compd. with N,N-dimethylacetamide (1:2) Solvents: Methanol
2.1 Reagents: Hydrogen tribromide, compd. with N,N-dimethylacetamide (1:2) Solvents: Methanol

Reference

Selective monobromination of ketones by bis(dimethylacetamide)hydrogen tribromide

Rodygin, M. Yu.; et al, Zhurnal Organicheskoi Khimii, 1994, 30(6), 827-32

Production Method 10

816-39-7

867-54-9

19686-73-8

Reaction Conditions

1.1 Reagents: Hydrogen peroxide ,  Potassium bromide Catalysts: Chloroperoxidase Solvents: Water ;  30 min, pH 3, rt

Reference

Halogenated ketones and aldehydes and their use as reactants for other products

, European Patent Organization, , ,

Production Method 11

534-07-6

816-39-7

Reaction Conditions

1.1 Reagents: Lithium bromide Solvents: Acetone ;  rt; 72 h, rt

Reference

Synthesis of α,β-unsaturated epoxy ketones utilizing a bifunctional sulfonium/phosphonium ylide

Eskandari, Roozbeh; et al, Chemical Communications (Cambridge, 2021, 57(58), 7136-7139

Production Method 12

22094-18-4

816-39-7

Reaction Conditions

1.1 Reagents: Sulfuric acid Solvents: Water ;  rt; 48 h, 50 °C

Reference

Use of isotope mass probes for metabolic analysis of the jasmonate biosynthetic pathway

Huang, Yun-Qing; et al, Analyst (Cambridge, 2011, 136(7), 1515-1522

Production Method 13

816-39-7

Reaction Conditions

1.1 Reagents: Bromine

Reference

Method of obtaining 1,3-dibromoacetone

, USSR, , ,

Production Method 14

816-39-7

Reaction Conditions

1.1 Reagents: Bromine Solvents: Methanol ;  2 h, rt; 16 h, rt → -20 °C
1.2 Reagents: Sulfuric acid Solvents: Water ;  -20 °C; 48 h, 60 °C

Reference

Synthesis of a Bis-thio-acetone (BTA) Analogue of the Lysine Isopeptide Bond and its Application to Investigate the Effects of Ubiquitination and SUMOylation on α-Synuclein Aggregation and Toxicity

Lewis, Yuka E.; et al, ACS Chemical Biology, 2016, 11(4), 931-942

Production Method 15

80395-70-6

816-39-7

Reaction Conditions

1.1 Catalysts: Methanol

Reference

Silyl- and germylcyclopropanones

Zaitseva, G. S.; et al, Zhurnal Obshchei Khimii, 1981, 51(10), 2252-66

Production Method 16

867-54-9

816-39-7

Reaction Conditions

Reference

Hydrobromic acid

Mills, John E., e-EROS Encyclopedia of Reagents for Organic Synthesis, 2001, 1, 1-6

Production Method 17

867-54-9

816-39-7

Reaction Conditions

1.1 Catalysts: Hydrogen bromide

Reference

Hydrobromic Acid

Mills, John E., e-EROS Encyclopedia of Reagents for Organic Synthesis, 2001, ,

Production Method 18

816-39-7

Reaction Conditions

1.1 Reagents: Bromine Solvents: Methanol ;  3 h, rt; 2 h, rt
2.1 Reagents: Sulfuric acid Solvents: Water ;  48 h, 50 °C

Reference

Highly sensitive profiling assay of acidic plant hormones using a novel mass probe by capillary electrophoresis-time of flight-mass spectrometry

Chen, Ming-Luan; et al, Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 2011, 879(13-14), 938-944

Production Method 19

816-39-7

Reaction Conditions

1.1 Reagents: Bromine Solvents: Methanol ;  25 °C; 2 h, 25 °C
2.1 Reagents: Sulfuric acid Solvents: Water ;  48 h, 60 °C

Reference

Use of isotope differential derivatization for simultaneous determination of thiols and oxidized thiols by liquid chromatography tandem mass spectrometry

Huang, Yun-Qing; et al, Analytical Biochemistry, 2011, 416(2), 159-166

Production Method 20

816-39-7

Reaction Conditions

1.1 Reagents: Potassium bromide ;  72 h, 50 °C
2.1 Reagents: Periodic acid (H5IO6) Solvents: Acetonitrile ;  3 h, rt

Reference

Expeditious syntheses to pharmochemicals 1,3-dihydroxyacetone, 1,3-dichloro-, 1,3-dibromo- and 1,3-diiodoacetone from glycerol 1,3-dichlorohydrin using homogenous and heterogenous medium

da Silva, Fernanda Priscila N. R.; et al, Journal of the Brazilian Chemical Society, 2020, 31(8), 1725-1731

Production Method 21

56-81-5

816-39-7

Reaction Conditions

1.1 Reagents: Hydrochloric acid Solvents: Acetic acid ;  6 h, 100 °C
2.1 Reagents: Potassium bromide ;  72 h, 50 °C
3.1 Reagents: Periodic acid (H5IO6) Solvents: Acetonitrile ;  3 h, rt

Reference

Expeditious syntheses to pharmochemicals 1,3-dihydroxyacetone, 1,3-dichloro-, 1,3-dibromo- and 1,3-diiodoacetone from glycerol 1,3-dichlorohydrin using homogenous and heterogenous medium

da Silva, Fernanda Priscila N. R.; et al, Journal of the Brazilian Chemical Society, 2020, 31(8), 1725-1731

Production Method 22

816-39-7

867-54-9

Reaction Conditions

1.1 Reagents: Seleninyl bromide Solvents: Carbon tetrachloride

Reference

Halogenation of aldehydes and ketones by selenium(IV) oxyhalides generated in-situ from selenium dioxide and halotrimethylsilanes

Lee, Jong Gun; et al, Bulletin of the Korean Chemical Society, 1995, 16(4), 349-55

Production Method 23

816-39-7

867-54-9

Reaction Conditions

1.1 Reagents: Oxygen ,  Hydrogen bromide Catalysts: Tetraglyme ,  Molybdovanadophosphoric acid (H5PMo10V2O40) Solvents: 1,2-Dichloroethane

Reference

Oxybromination catalyzed by the heteropolyanion compound H5PMo10V2O40 in an organic medium: selective para-bromination of phenol

Neumann, Ronny; et al, Journal of the Chemical Society, 1988, (19), 1285-7

Production Method 24

816-39-7

867-54-9

Reaction Conditions

1.1 Reagents: Hydrochloric acid Solvents: Water
1.2 Reagents: Bromine

Reference

Reaction of sulfur tetrafluoride with 1,3-dihaloacetones. Fluoroalkylation of benzene as evidence of participation of fluorocarbocations in the reaction

Wielgat, J.; et al, Journal of Fluorine Chemistry, 1987, 35(4), 643-52

Production Method 25

816-39-7

867-54-9

Reaction Conditions

1.1 Reagents: Hydrogen peroxide ,  Potassium bromide Catalysts: Chloroperoxidase Solvents: Water ;  30 min, pH 4, rt

Reference

Halogenated ketones and aldehydes and their use as reactants for other products

, European Patent Organization, , ,

1,3-Dibromoacetone, Technical Grade Raw materials

• 1,3-Dibromo-2-propanol
• 1,3-dibromo-2,2-dimethoxy-propane
• 1,1-dibromoacetone
• Glycerol
• 1,3-Dichloroacetone
• 2-Propanone, 1,3-dibromo-1-(trimethylsilyl)-

1,3-Dibromoacetone, Technical Grade Preparation Products

• 1,1-dibromoacetone (867-54-9)
• 1,3-Dibromoacetone, Technical Grade (816-39-7)
• 1-bromopropan-2-ol (19686-73-8)

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• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Ketones
• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Carbonyl compounds Ketones

• 1190006-20-2(1,3-DIBROMOACETONE-2-13C)
• 1313734-85-8(1,3-Dibromoacetone-13C3)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)