Production Method 1

811-68-7

Reaction Conditions

1.1 Reagents: Silver fluoride Solvents: Acetonitrile ;  overnight, 80 °C

Reference

Synthesis of Indole-Substituted Trifluoromethyl Sulfonium Ylides by Cp*Rh(III)-Catalyzed Diazo-carbenoid Addition to Trifluoromethylthioether

Chen, Shao-Yong; et al, Journal of Organic Chemistry, 2023, 88(9), 5512-5519

Production Method 2

81290-20-2

373-68-2

811-68-7

Reaction Conditions

1.1 Reagents: Sulfur Solvents: Tetrahydrofuran ;  rt; rt → -60 °C
1.2 30 min, -60 °C; 16 h, -60 °C → rt
2.1 Reagents: Silver nitrate Solvents: Acetonitrile ;  24 h, rt

Reference

A new synthesis of trifluoromethanethiolates-characterization and properties of tetramethylammonium, cesium and di(benzo-15-crown-5)cesium trifluoromethanethiolates

Tyrra, Wieland; et al, Journal of Fluorine Chemistry, 2003, 119(1), 101-107

Production Method 3

824-79-3

81290-20-2

811-68-7

372-64-5

Reaction Conditions

1.1 Reagents: Aniline ,  (Diethylamino)sulfur trifluoride
2.1 Reagents: Potassium persulfate ,  Silver fluoride Solvents: Dimethyl sulfoxide ;  3 h, 20 °C

Reference

Silver-mediated radical aryltrifluoromethylthiolation of activated alkenes by S-trifluoromethyl 4-methylbenzenesulfonothioate

Zhao, Xia; et al, Tetrahedron Letters, 2018, 59(18), 1719-1722

Production Method 4

811-68-7

Reaction Conditions

1.1 Reagents: Silver fluoride Solvents: Acetonitrile ;  12 h, 80 °C

Reference

Visible-light-induced dehydrogenative β-trifluoromethylthiolation of tertiary amines and direct β-trifluoromethylthiolation of enamides

Song, Yaqi; et al, Organic Chemistry Frontiers, 2023, 10(20), 5284-5290

Production Method 5

811-68-7

Reaction Conditions

1.1 Reagents: Silver fluoride Solvents: Acetonitrile ;  12 h, 80 °C

Reference

N-[(Trifluoromethyl)thio]saccharin: An Easily Accessible, Shelf-Stable, Broadly Applicable Trifluoromethylthiolating Reagent

Xu, Chunfa; et al, Angewandte Chemie, 2014, 53(35), 9316-9320

Production Method 6

21259-75-6

811-68-7

Reaction Conditions

1.1 Reagents: Silver nitrate Solvents: Water

Reference

Silver trifluoromethylthiolate

Hervert, Katherine, e-EROS Encyclopedia of Reagents for Organic Synthesis, 2015, 1, 1-3

Production Method 7

83193-05-9

51-92-3

811-68-7

Reaction Conditions

1.1 Reagents: Silver nitrate Solvents: Acetonitrile ;  24 h, rt

Reference

A new synthesis of trifluoromethanethiolates-characterization and properties of tetramethylammonium, cesium and di(benzo-15-crown-5)cesium trifluoromethanethiolates

Tyrra, Wieland; et al, Journal of Fluorine Chemistry, 2003, 119(1), 101-107

Production Method 8

15223-20-8

811-68-7

372-64-5

Reaction Conditions

1.1 Reagents: Potassium persulfate ,  Silver fluoride Solvents: Dimethyl sulfoxide ;  3 h, 20 °C

Reference

Silver-mediated radical aryltrifluoromethylthiolation of activated alkenes by S-trifluoromethyl 4-methylbenzenesulfonothioate

Zhao, Xia; et al, Tetrahedron Letters, 2018, 59(18), 1719-1722

Production Method 9

15223-20-8

811-68-7

455-16-3

Reaction Conditions

1.1 Reagents: Silver fluoride Solvents: Dimethyl sulfoxide ;  12 h, 20 °C

Reference

Silver-mediated radical aryltrifluoromethylthiolation of activated alkenes by S-trifluoromethyl 4-methylbenzenesulfonothioate

Zhao, Xia; et al, Tetrahedron Letters, 2018, 59(18), 1719-1722

Production Method 10

824-79-3

81290-20-2

811-68-7

455-16-3

Reaction Conditions

1.1 Reagents: Aniline ,  (Diethylamino)sulfur trifluoride
2.1 Reagents: Silver fluoride Solvents: Dimethyl sulfoxide ;  12 h, 20 °C

Reference

Silver-mediated radical aryltrifluoromethylthiolation of activated alkenes by S-trifluoromethyl 4-methylbenzenesulfonothioate

Zhao, Xia; et al, Tetrahedron Letters, 2018, 59(18), 1719-1722

Silver(I) Trifluoromethanethiolate Raw materials

• Benzenesulfonothioicacid, 4-methyl-, S-(trifluoromethyl) ester
• Sodium toluene-4-sulphinate
• bis(trifluoromethylthio)mercury
• Methanethiol, trifluoro-, ion(1-) (9CI)
• trimethyl(trifluoromethyl)silane
• Tetramethylammonium fluoride
• tetramethylammonium

Silver(I) Trifluoromethanethiolate Preparation Products

• 4-methylbenzene-1-sulfonyl fluoride (455-16-3)
• Bis(trifluoromethyl)disulfide (372-64-5)
• Silver(I) Trifluoromethanethiolate (811-68-7)

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• Solvents and Organic Chemicals Organic Compounds Organohalogen compounds Alkyl halides Halomethanes Trihalomethanes
• Solvents and Organic Chemicals Organic Compounds Organic Halides
• Other Chemical Reagents

• 3872-23-9(Copper(I) Trifluoromethanethiolate)
• 21259-75-6(bis(trifluoromethylthio)mercury)
• 83193-05-9(Methanethiol, trifluoro-, ion(1-) (9CI))
• 29245-71-4(cf3s)
• 1493-15-8(Methanethiol,trifluoro- (6CI,7CI,8CI,9CI))
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)