Production Method 1

81053-18-1

Reaction Conditions

1.1 Catalysts: Benzyltrimethylammonium hydroxide Solvents: Tetrahydrofuran ;  1 h, rt

Reference

Protection of the Carbonyl Group as 1,2,4-Trioxane and Its Regeneration under Basic Conditions

Singh, Chandan; et al, Organic Letters, 2005, 7(25), 5673-5676

Production Method 2

189509-22-6

81053-18-1

Reaction Conditions

1.1 Reagents: Acetic acid Solvents: Water ;  12 h, 90 °C
1.2 Reagents: Sodium bicarbonate Solvents: Water

Reference

Chemo-enzymic preparation of rengyoside-A, -B, isorengyoside and preparation of their aglycons

Soriente, Annunziata; et al, Tetrahedron, 1997, 53(13), 4693-4702

Production Method 3

4746-97-8

105-36-2

81053-18-1

Reaction Conditions

1.1 Catalysts: Zinc Solvents: Benzene ;  30 min, reflux; 1 h, rt
2.1 Reagents: Acetic acid Solvents: Water ;  12 h, 90 °C
2.2 Reagents: Sodium bicarbonate Solvents: Water

Reference

Chemo-enzymic preparation of rengyoside-A, -B, isorengyoside and preparation of their aglycons

Soriente, Annunziata; et al, Tetrahedron, 1997, 53(13), 4693-4702

Production Method 4

105-36-2

678967-25-4

81053-18-1

Reaction Conditions

1.1 Reagents: Zinc Solvents: Benzene ;  0.5 h, rt; 3 h, reflux; reflux → 50 °C
1.2 Solvents: Benzene ;  4 h, 50 °C; 50 °C → 0 °C
1.3 Reagents: Sulfuric acid Solvents: Water
2.1 Catalysts: Benzyltrimethylammonium hydroxide Solvents: Tetrahydrofuran ;  1 h, rt

Reference

Protection of the Carbonyl Group as 1,2,4-Trioxane and Its Regeneration under Basic Conditions

Singh, Chandan; et al, Organic Letters, 2005, 7(25), 5673-5676

ethyl 2-(1-hydroxy-4-oxo-cyclohexyl)acetate Raw materials

• 1,4-Dioxaspiro[4.5]decan-8-one
• Ethyl bromoacetate
• 1,2,5-Trioxaspiro[5.5]undecan-9-one, 3-(1-phenylethenyl)-
• Ethyl 2-(8-hydroxy-1,4-dioxaspiro[4.5]decan-8-yl)acetate

ethyl 2-(1-hydroxy-4-oxo-cyclohexyl)acetate Preparation Products

• ethyl 2-(1-hydroxy-4-oxo-cyclohexyl)acetate (81053-18-1)

• 1. Exchanged ligands on the surface of a giant cluster: [(MoO3)176(H2O)63(CH3OH)17Hn](32 – n)–
  Chem. Commun., 1998, 1501-1502
• 2. Evolution of hierarchical porous structures in supramolecular guest–host hydrogels?
  Christopher B. Rodell,Christopher B. Highley,Minna H. Chen,Neville N. Dusaj,Chao Wang,Lin Han,Jason A. Burdick Soft Matter, 2016,12, 7839-7847
• 3. Excimer formation effects and trap-assisted charge recombination loss channels in organic solar cells of perylene diimide dimer acceptors?
  Min Kim,Jae-Joon Lee,Tengling Ye,Panagiotis E. Keivanidis,Kilwon Cho J. Mater. Chem. C, 2020,8, 1686-1696
• 4. Ester-directed orthogonal dual C–H activation and ortho aryl C–H alkenylation via distal weak coordination?
  Manickam Bakthadoss,Tadiparthi Thirupathi Reddy,Vishal Agarwal,Duddu S. Sharada Chem. Commun., 2022,58, 1406-1409
• 5. Enantio- & chemo-selective preparation of enantiomerically enriched aliphatic nitro alcohols using Candida parapsilosis ATCC 7330
  Sowmyalakshmi Venkataraman RSC Adv., 2015,5, 73807-73813

• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Tertiary alcohols
• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Alcohols and polyols Tertiary alcohols

• 117678-63-4(Cyclohexaneheptanoicacid, b-hydroxy-2-[(2-methyl-1-oxobutoxy)methyl]-d-oxo-, [1R-[1a(R*),2b(S*)]]- (9CI))
• 5108-87-2(Cyclohexaneacetic acid, 1-hydroxy-2-methyl-, ethyl ester)
• 89768-17-2(Cyclohexanecarboxylic acid, 2-hydroxy-2-methyl-4-oxo-, ethyl ester, trans- (9CI))
• 84434-61-7(Cyclohexaneacetic acid,1-hydroxy-3,3,5-trimethyl-, ethyl ester)
• 6946-48-1(Cyclohexaneacetic acid, 1-hydroxy-, butyl ester)
• 6946-66-3(Cyclohexaneacetic acid,1-hydroxy-, 3-methylbutyl ester)
• 91328-33-5(Butanoic acid, 3-oxo-, 1-methylcyclohexyl ester)
• 5292-13-7(Cyclohexaneacetic acid,1-hydroxy-, 1,1-dimethylethyl ester)
• 61589-84-2(1-Oxaspiro[4.5]decane-2,7-dione)
• 87763-99-3(2-Propanone, 1-[1-(acetyloxy)cyclohexyl]-)