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Cas no 81-24-3 (TAUROCHOLIC ACID)

Taurocholic acid is a bile acid conjugate formed from cholic acid and taurine, playing a critical role in lipid digestion and absorption. It acts as a natural surfactant, facilitating the emulsification and solubilization of dietary fats in the intestinal tract. This compound is widely utilized in biochemical and pharmaceutical research due to its stability and compatibility with biological systems. Its applications include cell culture media formulations, membrane protein studies, and drug delivery systems. Taurocholic acid is valued for its high purity, reproducibility, and ability to mimic physiological conditions, making it a reliable choice for in vitro and in vivo studies.
TAUROCHOLIC ACID structure

Product Name:TAUROCHOLIC ACID

  • CAS No:81-24-3
  • CID:721468
  • MF:C26H45NO7S
  • MDL:MFCD00053458
  • MW:515.703007459641
  • Update Time:2025-10-21

Chemical and Physical Properties

TAUROCHOLIC ACID Chemical and Physical Properties

Names and Identifiers
    • TAUROCHOLIC ACID
    • 2-((3-alpha,7-alpha,12-alpha-trihydroxy-24-oxo-5-beta-cholan-24-yl)amino)ethan
    • 3,7,12-Trihydroxy-5-cholan-24-oicacid24-taurineamide
    • cholicacidtaurineconjugate
    • cholyltaurine
    • Cholytaurine
    • ethanesulfonicacid,2-(((3alpha,5beta,7alpha,12alpha)-3,7,12-trihydroxy-24-oxo
    • 2-[[(4R)-4-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-trihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoyl]amino]ethanesulfonic acid
    • Ethanesulfonic acid,2-[[(3a,5b,7a,12a)-3,7,12-trihydroxy-24-oxocholan-24-yl]amino]-
    • TAUROCHOLICACID
    • 3.alpha.,12.alpha.-Trihydroxy-5.beta.-cholanic acid 24-taurine
    • 2-[(3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholan-24-yl)amino]ethanesulfonic acid
    • 2-(((3alpha,5beta,7alpha,12alpha)-3,7,12-Trihydroxy-24-oxocholan-24-yl)amino)ethanesulfonic acid
    • 2-[(4R)-4-[(1S,2S,5R,7S,9R,10R,11S,14R,15R,16S)-5,9,16-trihydroxy-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadecan-14-yl]pentanamido]ethane-1-sulfonic acid
    • DTXSID00883259
    • CHEBI:28865
    • bmse000927
    • NSC 25505
    • 2-((3-alpha,7-alpha,12-alpha-Trihydroxy-24-oxo-5-be ta-cholan-24-yl)amino)ethanesulfonic acid
    • GTPL4547
    • T-1150
    • 3.BETA.-HYDROXYDINOR-5-CHOLENIC ACID
    • EINECS 201-336-2
    • 81-24-3
    • NSC-25505
    • [3H]taurocholic acid
    • 2-{[(3Alpha,5beta,7alpha,12alpha)-3,7,12-trihydroxy-24-oxocholan-24-yl]amino}ethanesulfonic acid
    • 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholanic acid 24-taurine
    • 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholan-24-oic acid N-(2-sulfoethyl)amide
    • NSC25505
    • HMS2090N18
    • WLN: L E5 B666TJ A1 DQ E1 FY1&2VM2SWQ KQ OQ
    • Ethanesulfonic acid, 2-(((3alpha,5beta,7alpha,12alpha)-3,7,12-trihydroxy-24-oxocholan-24-yl)amino)-
    • BIDD:PXR0195
    • Taurocholate
    • TAUROCHOLIC ACID [HSDB]
    • HSDB 832
    • GTPL4546
    • CHEMBL224867
    • AKOS030242840
    • 2-[(4R)-4-[(1R,3aS,3bR,4R,5aS,7R,9aS,9bS,11S,11aR)-4,7,11-trihydroxy-9a,11a-dimethyl-hexadecahydro-1H-cyclopenta[a]phenanthren-1-yl]pentanamido]ethane-1-sulfonic acid
    • N-choloyl-taurine
    • MS-29575
    • Choloyl-taurine
    • 2-[(3.alpha.,12.alpha.-Trihydroxy-24-oxo-5.beta.-cholan-24-yl)amino]ethanesulfonic acid
    • SCHEMBL3705
    • Cholaic acid
    • UNII-5E090O0G3Z
    • N-(3Alpha,7Alpha,12Alpha-trihydroxy-5Beta-cholan-24-oyl)-taurine
    • N-Choloyltaurine
    • Spectrum5_002015
    • LMST05040001
    • EN300-19734139
    • Cholic acid taurine conjugate
    • SR-05000001533-1
    • DB04348
    • AB01275537-01
    • SR-05000001533
    • TAUROCHOLIC ACID [MI]
    • [3H]-taurocholate
    • BDBM50375594
    • Taurine, N-choloyl-
    • Sodium taurocholate hydrate
    • NS00002884
    • Ethanesulfonic acid, 2-[[(3.alpha.,5.beta.,7.alpha.,12.alpha.)-3,7,12-trihydroxy-24-oxocholan-24-yl]amino]-
    • Ethanesulfonic acid,5.beta.,7.alpha.,12.alpha.)-3,7,12-trihydroxy-24-oxocholan-24-yl]amino]-
    • Taurocholic acid sodium salt hydrate
    • 2-(((3.ALPHA.,5.BETA.,7.ALPHA.,12.ALPHA.)-3,7,12-TRIHYDROXY-24-OXOCHOLAN-24-YL)AMINO)ETHANESULFONIC ACID
    • 5E090O0G3Z
    • 3a,7a,12a-Trihydroxy-5b-cholanic acid-24-taurine
    • [3H]-taurocholic acid
    • 2-(((3alpha,5beta,7alpha,12alpha)-3,7,12-Trihydroxy-24-oxocholan-24-yl)amino)ethanesulphonic acid
    • Acidum cholatauricum
    • 2-{[(3beta,5beta,7alpha,12alpha,14beta,17alpha)-3,7,12-trihydroxy-24-oxocholan-24-yl]amino}ethanesulfonic acid
    • CS-0013819
    • HY-B1788
    • Q2659931
    • Taurine Cholate
    • ethanesulfonic acid, 2-[[(3alpha,5beta,7alpha,12alpha)-3,7,12-trihydroxy-24-oxocholan-24-yl]amino]-
    • BRD-K81062487-001-05-8
    • G12125
    • WBWWGRHZICKQGZ-HZAMXZRMSA-N
    • tauro-cholic acid
    • MDL： MFCD00053458
    • Inchi： 1S/C26H45NO7S/c1-15(4-7-23(31)27-10-11-35(32,33)34)18-5-6-19-24-20(14-22(30)26(18,19)3)25(2)9-8-17(28)12-16(25)13-21(24)29/h15-22,24,28-30H,4-14H2,1-3H3,(H,27,31)(H,32,33,34)/t15-,16+,17-,18-,19+,20+,21-,22+,24+,25+,26-/m1/s1
    • InChI Key： WBWWGRHZICKQGZ-HZAMXZRMSA-N
    • SMILES： S(CCNC(CC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3[C@@H](C[C@@H]4C[C@@H](CC[C@]4(C)[C@H]3C[C@@H]([C@@]21C)O)O)O)=O)(=O)(=O)O
Computed Properties
    • Exact Mass: 515.29200
    • Monoisotopic Mass: 404.119463
    • Isotope Atom Count: 0
    • Hydrogen Bond Donor Count: 5
    • Hydrogen Bond Acceptor Count: 8
    • Heavy Atom Count: 35
    • Rotatable Bond Count: 8
    • Complexity: 571
    • Covalently-Bonded Unit Count: 1
    • Defined Atom Stereocenter Count: 0
    • Undefined Atom Stereocenter Count : 1
    • Defined Bond Stereocenter Count: 0
    • Undefined Bond Stereocenter Count: 0
    • XLogP3: 2.3
    • Topological Polar Surface Area: 76.9
Experimental Properties
    • Color/Form: Powder
    • Density: 1.0902 (rough estimate)
    • Melting Point: 125°C (rough estimate)
    • Refractive Index: 1.5650 (estimate)
    • PSA: 152.54000
    • LogP: 3.83980
    • pka: 1.4(at 25℃)
    • Specific Rotation: D18 +38.8° (c = 2 in alcohol)

TAUROCHOLIC ACID Security Information

81-24-3 (TAUROCHOLIC ACID) Global Suppliers

Product Overview and Price Analysis

Taurocholic acid (CAS 81-24-3) is a bile acid conjugate, specifically the taurine conjugate of cholic acid. It is a key component of bile, playing a vital role in the emulsification and absorption of dietary fats and fat-soluble vitamins in the intestine.

CAS no.81-24-3 comprehensive analysis

+View Details

Based on current supplier listings, Taurocholic acid is a high-purity biochemical reagent with a premium price point. Prices vary significantly based on purity grade (e.g., >98%, >99%), quantity (research vs. bulk), and supplier reputation. Bulk orders typically offer better value.

The main factors affecting prices include:

  • Purity Grade: Higher purity (>99%) commands a significantly higher price.
  • Order Quantity: Bulk purchases (kg scale) offer substantial per-unit cost reductions.
  • Supplier/Brand: Established biochemical brands often have premium pricing.
  • Packaging: Specialized packaging (e.g., under inert gas) increases cost.
  • Supply Chain: Regional availability and logistics impact final landed cost.

High quality verification supplier (strong customization capability)

Tiancheng Chemical (Jiangsu) Co., Ltd

Tiancheng Chemical (Jiangsu) Co., Ltd

Gold Member
Audited Supplier Audited Supplier
江蘇, CN
Tiancheng Chemical is a high-tech enterprise specializing in R&D, production, and sales of eco-friendly fine chemicals, including UV resins and specialty solvents for electronics and new materials.

(CAS:81-24-3)Taurocholic Acid

  • Order Number: LE12869;LE27063381
  • Quantity: 25KG,200KG,1000KG
  • Price ($): discuss personally
  • Stock Status: in Stock
  • Purity: 99%
  • Last Updated: Friday, 20 June
SHOCHEM(SHANGHAI) CO.,lTD

SHOCHEM(SHANGHAI) CO.,lTD

Gold Member
Audited Supplier Audited Supplier
上海, CN
SHOCHEM is a high-tech enterprise specializing in pharmaceutical R&D, focusing on camptothecin derivatives, lipid-based nucleic acid delivery excipients, and high-purity synthetic phospholipids.

(CAS:81-24-3)Taurocholic Acid

  • Order Number: 0236
  • Quantity: 100mg;500mg;1g
  • Price ($):
  • Stock Status: in Stock
  • Purity: 98%min
  • Last Updated: Thursday, 21 August

TAUROCHOLIC ACID Research More >>

Related Categories No. Product Name Cas No. Purity Specification Price update time Inquiry
ChemScence
CS-0013819-5mg
Taurocholic acid
 81-24-3 99.18%
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ChemScence
CS-0013819-10mg
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ChemScence
CS-0013819-25mg
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SHANG HAI JI ZHI SHENG HUA Technology Co., Ltd.
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SHANG HAI TAO SHU Biotechnology Co., Ltd.
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WU HAN AN JIE KAI Biomedical Technology Co., Ltd.
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TRC
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TRC
T008145-10mg
Taurocholic Acid
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 $ 131.00 2023-09-06
TRC
T008145-100mg
Taurocholic Acid
 81-24-3
100mg
 $ 195.00 2023-09-06
TRC
T008145-250mg
Taurocholic Acid
 81-24-3
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Comparison of Global Market Sizes

Based on the analysis of relevant compound market data, the performance of the segmented market to which CAS No. (81-24-3) belongs is as follows:
Market category Market size Growth rate(CAGR) Main driving factors
Global Bile Acids Market USD 2.5-3.0 Billion ~7-9% CAGR Growing demand for pharmaceutical APIs (e.g., Ursodeoxycholic acid).
Increasing use in research on metabolic and liver diseases.
Steroid & Hormone API Market USD 15-18 Billion ~5-7% CAGR Aging population and rising chronic disease prevalence.
Advancements in targeted drug delivery systems.
Biochemical Reagents & Research Market USD 25-30 Billion ~8-10% CAGR Expansion of life sciences R&D, especially in cell biology.
Increased funding for metabolic disorder research.
Taurocholic Acid (Estimated) USD 50-80 Million ~8-12% CAGR Critical role as a reference standard and research tool.
Emerging applications in cell culture and drug permeability studies.

Applications & Uses of TAUROCHOLIC ACID

TAUROCHOLIC ACID(Cas no 81-24-3) Biochemical & Pharmaceutical Research (~65%)
TAUROCHOLIC ACID(Cas no 81-24-3) Biochemical & Pharmaceutical Research (~65%)
Taurocholic acid serves as a fundamental research tool in biochemistry and pharmacology. It is extensively used as a reference standard in analytical methods like HPLC and LC-MS for quantifying bile acids in biological samples. Researchers employ it to study bile acid metabolism, transport mechanisms (e.g., via the bile salt export pump, BSEP), and their role in liver function, cholestasis, and intestinal absorption. Its ability to form micelles makes it crucial for studying lipid digestion and the solubilization of hydrophobic compounds. Furthermore, it is a key component in simulating physiological conditions for in vitro drug permeability assays (e.g., Caco-2 models) to predict oral drug absorption.
TAUROCHOLIC ACID(Cas no 81-24-3) Cell Culture & Biotechnology (~25%)
TAUROCHOLIC ACID(Cas no 81-24-3) Cell Culture & Biotechnology (~25%)
In cell culture, taurocholic acid is used as a supplement in specific media formulations, particularly for primary hepatocyte cultures and other liver-derived cell lines. It helps maintain hepatocyte differentiation, polarity, and metabolic functions by mimicking the natural biliary environment. This application is vital for toxicology studies, drug metabolism research (hepatotoxicity screening), and modeling liver diseases. In biotechnology, it acts as a biological detergent or solubilizing agent for membrane proteins, aiding in their extraction and purification while preserving native structure and activity. Its use is growing in complex 3D cell culture systems and organ-on-a-chip technologies designed to model human physiology.
TAUROCHOLIC ACID(Cas no 81-24-3) Pharmaceutical Intermediate & Diagnostics (~10%)
TAUROCHOLIC ACID(Cas no 81-24-3) Pharmaceutical Intermediate & Diagnostics (~10%)
While not a final active pharmaceutical ingredient itself, taurocholic acid is a critical starting material or intermediate in the synthesis of other bile acid derivatives and conjugated compounds for pharmaceutical use. It also finds application in the diagnostics sector. It is used to prepare calibrators and controls for clinical diagnostic kits that measure total bile acids (TBA) in serum or plasma, which is an important biomarker for liver function and hepatobiliary diseases. Elevated TBA levels can indicate conditions like cholestasis, hepatitis, or cirrhosis. The high-purity taurocholic acid ensures accuracy and reliability in these diagnostic tests, supporting clinical decision-making.

81-24-3 (TAUROCHOLIC ACID) Related Products

TAUROCHOLIC ACID Analysis

Analysis of Regional Market Characteristics and Demand

Geographical distribution characteristics
Production End
Production is concentrated in North America (US) and Europe (Germany, Switzerland).
Leading global biochemical and fine chemical suppliers dominate manufacturing.
High-purity synthesis requires specialized expertise and GMP-like facilities.
China and India are emerging as producers of standard-grade material.
Consumption End
Primary demand originates from North America and Europe's robust life science sectors.
Asia-Pacific (Japan, China, South Korea) shows fastest-growing consumption.
Demand is driven by academic institutes, pharmaceutical R&D, and CROs.
Consumption patterns are closely tied to regional biomedical research funding.
European Market
Characterized by stringent quality standards (Ph. Eur.) and regulatory oversight.
Strong demand from pharmaceutical and diagnostic industries.
Prices are generally higher due to compliance and quality assurance costs.
Supply chains are stable with established regional distributors.
Asia-Pacific Market
Market is rapidly expanding with growing domestic R&D investment.
Price sensitivity is higher, with competition from local manufacturers.
Quality variance can be significant; verification of CoA is crucial.
Logistics hubs in Singapore and China facilitate regional distribution.

Safety and regulatory requirements

Hazard classification
CasNo 81-24-3 is classified as a biochemical substance with low acute toxicity but requires careful handling.
Irritant: May cause skin, eye, and respiratory tract irritation upon contact.
Environmental Hazard: Potential long-term adverse effects on aquatic life.
No significant flammability or explosivity under normal conditions.
Storage and transportation requirements
Storage conditions: Store in a tightly sealed container at 2-8°C, protected from light and moisture.
Transportation classification: Not classified as dangerous goods for transport under most regulations (e.g., IATA, ADR).
Packaging requirements: Use appropriate chemical-resistant containers. For high purity, consider inert gas purging.
Identification requirements: Label must include product name, CAS number, hazard symbols (irritant), and storage conditions.

Supply chain risk assessment

Geographic Concentration Risk
High-purity production is concentrated in few Western countries.
Potential for disruption from regional regulatory changes or trade policies.
Logistics for cold-chain transport add complexity and vulnerability.
Compliance Risk
Must comply with REACH, TSCA, and other regional chemical regulations.
Documentation (CoA, MSDS) must be accurate and provided by reputable suppliers.
Risk of non-compliant or mislabeled material from unverified sources.
Technical Risk
Synthesis of high-purity (>99%) material requires specialized expertise.
Risk of product degradation if storage/transport conditions are not maintained.
Analytical methods for purity verification are critical and require resources.
Market Risk
Demand is niche and tied to research funding cycles, causing volatility.
Prices for high-purity grades can be sensitive to raw material (cholic acid/taurine) costs.
Competition from alternative bile salts or synthetic surfactants in some applications.

Procurement Suggestions and Strategies

Supplier selection strategy
Top Choice: Sigma-Aldrich (Merck)
As a global leader in life science reagents, Sigma-Aldrich offers guaranteed high purity (e.g., >99%), comprehensive analytical documentation (CoA, MSDS), and reliable global supply chains. Their brand reputation ensures consistency and quality, which is critical for research reproducibility and regulatory compliance, justifying the premium price for most applications.

Alternative Option: Cayman Chemical
Cayman Chemical specializes in biochemicals and offers high-quality taurocholic acid, often with detailed biological activity data. They are a strong alternative for research-focused procurement, especially in pharmacology and cell-based assays, providing reliable quality and good technical support at a competitive price point compared to the largest distributors.

Cost Optimization: TCI Chemicals
TCI provides a cost-effective option for standard-grade taurocholic acid suitable for general laboratory use where ultra-high purity is not the primary concern. They maintain good quality control for their price segment and have a strong distribution network in Asia, making them a viable choice for budget-conscious procurement of larger quantities for routine applications.

Procurement execution suggestions
Pre-Procurement Preparation:
Clearly define required purity grade, quantity, and intended application.
Research and shortlist 3-5 reputable suppliers with valid documentation.
Prepare budget and understand total cost including shipping and duties.

Supplier Evaluation & Quotation:
Request and meticulously review Certificates of Analysis (CoA) from suppliers.
Compare quotations based on total landed cost, not just unit price.
Verify supplier lead times, packaging options, and cold-chain logistics.

Order Placement & Receipt:
Place order specifying CAS number, purity, packaging, and storage requirements.
Confirm shipping method and tracking details with the supplier.
Upon receipt, immediately inspect packaging and store under recommended conditions.

Conclusion

Procuring Taurocholic Acid (81-24-3) requires a balance between quality assurance, cost, and supply reliability. Prioritize suppliers like Sigma-Aldrich for critical research where purity and documentation are paramount. For cost-sensitive bulk orders, consider reputable alternatives like TCI, but always verify CoAs. Key to success is defining specifications upfront, understanding total landed costs, and ensuring proper cold-chain logistics upon receipt to maintain product integrity.

Key points:
  • Prioritize suppliers with proven quality systems and complete documentation (CoA, MSDS).
  • Define purity requirements precisely based on application to avoid overspending.
  • Factor in all costs including shipping, duties, and potential cold-chain logistics.
  • Validate material upon receipt and adhere strictly to recommended storage conditions.