Production Method 1

315228-79-6

80945-83-1

Reaction Conditions

1.1 Reagents: Sulfuryl chloride ;  15 min, 20 - 25 °C
1.2 Reagents: Water ;  3 h, 20 - 25 °C
1.3 Reagents: Acetonitrile ,  Water

Reference

Water-Promoted Chlorination of 2-Mercaptobenzothiazoles

Wimmer, Laurin; et al, Synthesis, 2018, 50(10), 2027-2032

Production Method 2

63069-50-1

140-89-6

80945-83-1

Reaction Conditions

1.1 Solvents: Dimethylformamide ;  3 - 14 h, rt → 130 °C
1.2 Reagents: Hydrochloric acid Solvents: Water ;  130 °C → rt; pH 1 - 2, rt
2.1 Reagents: Sulfuryl chloride ;  15 min, 20 - 25 °C
2.2 Reagents: Water ;  3 h, 20 - 25 °C
2.3 Reagents: Acetonitrile ,  Water

Reference

Water-Promoted Chlorination of 2-Mercaptobenzothiazoles

Wimmer, Laurin; et al, Synthesis, 2018, 50(10), 2027-2032

2-chloro-1,3-benzothiazole-6-carbonitrile Raw materials

• 4-Amino-3-fluorobenzonitrile
• 2-Mercaptobenzo[d]thiazole-6-carbonitrile
• Potassium Ethyl Xanthogenate technical grade, 90%

2-chloro-1,3-benzothiazole-6-carbonitrile Preparation Products

• 2-chloro-1,3-benzothiazole-6-carbonitrile (80945-83-1)

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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Benzothiazoles Benzothiazoles
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Benzothiazoles

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• 252681-54-2(2-chloro-4,5-dimethyl-1,3-benzothiazole)
• 3507-26-4(2-chloro-6-methyl-1,3-benzothiazole)
• 615-20-3(2-chloro-1,3-benzothiazole)
• 3622-31-9(2-chloro-5-methyl-1,3-benzothiazole)
• 2942-24-7(2-chloro-7-methyl-1,3-benzothiazole)
• 176976-44-6(2-chloro-4-ethyl-1,3-benzothiazole)
• 104076-80-4(2-chloro-5,6-dimethyl-1,3-benzothiazole)
• 113072-25-6(Benzothiazole,2,5-dichloro-6-methyl-)