Production Method 1

80914-40-5

Reaction Conditions

1.1 Reagents: Hydrochloric acid Solvents: Water ;  1 h, reflux

Reference

New access to racemic β3-amino acids

Nejman, Michal; et al, Tetrahedron, 2005, 61(35), 8536-8541

Production Method 2

80914-40-5

Reaction Conditions

1.1 Reagents: Hydrochloric acid Solvents: Water ;  100 °C

Reference

Convenient procedure for synthesis of N-protected β-aminomalonates and β-amino acids from α-amidosulfones

Ananthanawat, Cheeraporn; et al, Synthetic Communications, 2006, 36(13), 1845-1855

Production Method 3

183444-00-0

105-53-3

80914-40-5

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Acetonitrile ;  24 h, rt
2.1 Reagents: Hydrochloric acid Solvents: Water ;  100 °C

Reference

Convenient procedure for synthesis of N-protected β-aminomalonates and β-amino acids from α-amidosulfones

Ananthanawat, Cheeraporn; et al, Synthetic Communications, 2006, 36(13), 1845-1855

Production Method 4

105-53-3

271600-32-9

80914-40-5

Reaction Conditions

1.1 Catalysts: Sodium hydride Solvents: Tetrahydrofuran ;  30 min, cooled; 2 h, rt; rt → 10 °C
1.2 Reagents: Ammonium chloride Solvents: Water ;  10 °C
2.1 Reagents: Hydrochloric acid Solvents: Water ;  1 h, reflux

Reference

New access to racemic β3-amino acids

Nejman, Michal; et al, Tetrahedron, 2005, 61(35), 8536-8541

3-amino-4-methylpentanoic acid hydrochloride Raw materials

• Carbamic acid, [2-methyl-1-(phenylsulfonyl)propyl]-, 1,1-dimethylethylester
• 1,3-diethyl propanedioate
• Carbamic acid, [2-methyl-1-[(4-methylphenyl)sulfonyl]propyl]-,1,1-dimethylethyl ester

3-amino-4-methylpentanoic acid hydrochloride Preparation Products

• 3-amino-4-methylpentanoic acid hydrochloride (80914-40-5)

• 1. Establishing the accuracy of position-specific carbon isotope analysis of propane by GC-pyrolysis-GC-IRMS
  ChangjieLiu,PengLiu,XiaofengWang,XiaoqiangLi,JuskeHorita
• 2. Enabling high-throughput single-animal gene-expression studies with molecular and micro-scale technologies
  Jason Wan Lab Chip, 2020,20, 4528-4538
• 3. Emergence of microfluidic wearable technologies
  Joo Chuan Yeo,Kenry Lab Chip, 2016,16, 4082-4090
• 4. Enabling chloride salts for thermal energy storage: implications of salt purity?
  J. Matthew Kurley,Phillip W. Halstenberg,Abbey McAlister,Stephen Raiman,Richard T. Mayes RSC Adv., 2019,9, 25602-25608
• 5. Evolution in surface coverage of CH3NH3PbI3?XClXvia heat assisted solvent vapour treatment and their effects on photovoltaic performance of devices
  Dhirendra K. Chaudhary,Pramendra Kumar,Lokendra Kumar RSC Adv., 2016,6, 94731-94738

Comprehensive Overview of 3-amino-4-methylpentanoic acid hydrochloride (CAS No. 80914-40-5)

3-amino-4-methylpentanoic acid hydrochloride (CAS No. 80914-40-5) is a specialized organic compound widely utilized in pharmaceutical research, biochemical studies, and synthetic chemistry. This hydrochloride salt derivative of 3-amino-4-methylpentanoic acid offers enhanced solubility and stability, making it a preferred choice for laboratory applications. Its molecular structure, featuring both amino and carboxyl functional groups, enables versatile reactivity, particularly in peptide synthesis and drug intermediate preparation.

In recent years, the demand for amino acid derivatives like 3-amino-4-methylpentanoic acid hydrochloride has surged due to their role in developing novel therapeutics. Researchers are particularly interested in its potential applications in neurological drug development, as modified amino acids can influence neurotransmitter pathways. The compound’s methyl group at the 4-position adds steric specificity, which is critical for targeted molecular interactions.

From an industrial perspective, CAS No. 80914-40-5 is synthesized through controlled reactions involving 4-methylpentenoic acid and ammonia, followed by hydrochloric acid treatment. The process emphasizes high purity (>98%), as impurities can affect downstream applications. Analytical techniques such as HPLC and NMR spectroscopy are routinely employed to verify its structural integrity and purity.

Environmental and safety considerations are paramount when handling 3-amino-4-methylpentanoic acid hydrochloride. While not classified as hazardous, proper storage conditions (e.g., dry, cool environments) are recommended to prevent degradation. The compound’s biodegradability and low toxicity profile align with green chemistry principles, a growing focus in modern pharmaceutical manufacturing.

Frequently searched questions related to this compound include: "What is the solubility of 3-amino-4-methylpentanoic acid hydrochloride?" (Answer: Highly soluble in water and polar solvents), and "Can CAS 80914-40-5 be used in peptide coupling reactions?" (Answer: Yes, its amino group is reactive toward carboxyl-activated esters). Addressing these queries enhances the compound’s accessibility for researchers.

Innovative applications of 3-amino-4-methylpentanoic acid hydrochloride extend to bioconjugation and prodrug design. For instance, its incorporation into peptide backbones can modulate drug release kinetics. Such advancements are frequently discussed in journals focusing on medicinal chemistry and biomaterials, reflecting the compound’s interdisciplinary relevance.

In summary, 3-amino-4-methylpentanoic acid hydrochloride (CAS No. 80914-40-5) represents a critical building block in synthetic and biomedical fields. Its unique properties, coupled with evolving applications, ensure sustained interest across academic and industrial sectors. Future research may explore its role in personalized medicine or sustainable drug formulation, further expanding its utility.

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