Production Method 1

1312033-12-7

80793-25-5

Reaction Conditions

1.1 Reagents: Formic acid Solvents: Toluene ;  1 h, reflux

Reference

New isothiocyanatotolane liquid crystals with terminal but-3-enyl substitute

Li, Juanli; Li, Jian; Hu, Minggang; An, Zhongwei; Peng, Zenghui; et al, Liquid Crystals, 2017, 44(5), 833-842

Production Method 2

589-87-7

80793-25-5

Reaction Conditions

1.1 Reagents: Benzyltriethylammonium chloride ,  Sodium bicarbonate Catalysts: Palladium diacetate Solvents: Dimethylformamide ;  5 h, 50 °C

Reference

Dehydrogenative desaturation-relay via formation of multicenter-stabilized radical intermediates

Shang, Yaping; Jie, Xiaoming; Jonnada, Krishna; Zafar, Syeda Nahid; Su, Weiping, Nature Communications, 2017, 8(1), 1-8

Production Method 3

25574-11-2

80793-25-5

Reaction Conditions

1.1 Reagents: Pyridinium chlorochromate Solvents: Dichloromethane ;  1 h, rt

Reference

Synthesis and fungicidal activity study of novel daphneolone analogs with 2,6-dimethylmorpholine

Xu, Gao-Fei; Yang, Xin-Ling; Lei, Peng; Liu, Xi-li; Zhang, Xue-Bo; et al, Chinese Chemical Letters, 2016, 27(4), 555-558

Production Method 4

5467-74-3

80793-25-5

Reaction Conditions

1.1 Reagents: Oxygen Catalysts: 2,9-Dimethyl-1,10-phenanthroline ,  Palladium diacetate ,  Cuprous chloride Solvents: Dimethyl sulfoxide ;  12 h, 1 atm, 50 °C

Reference

Replacing a stoichiometric silver oxidant with air: ligated Pd(II)-catalysis to β-aryl carbonyl derivatives with improved chemoselectivity

Vellakkaran, Mari; Andappan, Murugaiah M. S.; Kommu, Nagaiah, Green Chemistry, 2014, 16(5), 2788-2797

Production Method 5

589-87-7

80793-25-5

Reaction Conditions

1.1 Reagents: Sodium bicarbonate ,  Tetrabutylammonium chloride Catalysts: Palladium diacetate Solvents: Dimethylformamide

Reference

Synthesis and SAR of derivatives based on 2-biarylethylimidazole as bombesin receptor subtype-3 (BRS-3) agonists for the treatment of obesity

Liu, Jian; He, Shuwen; Jian, Tianying; Dobbelaar, Peter H.; Sebhat, Iyassu K.; et al, Bioorganic & Medicinal Chemistry Letters, 2010, 20(7), 2074-2077

Production Method 6

589-87-7

80793-25-5

Reaction Conditions

1.1 Reagents: Sodium bicarbonate ,  Tetrabutylammonium chloride Catalysts: Palladium diacetate Solvents: Dimethylformamide ;  rt; rt → 45 °C; 24 h, 45 °C

Reference

Formation of β-Oxo-N-vinylimidates via Intermolecular Ester Incorporation in Huisgen Cyclization/Carbene Cascade Reactions

Wang, Qinxuan; May, Jeremy A., Organic Letters, 2020, 22(24), 9579-9584

Production Method 7

3893-18-3

80793-25-5

Reaction Conditions

1.1 Reagents: Methyldiethoxysilane Catalysts: (OC-6-14)-Bis(acetato-κO)aqua[2,6-bis(4,5-dihydro-2-oxazolyl-κN3)-4-(1,1-dimethy… Solvents: Toluene ;  0.5 - 1 h, 60 °C; 60 °C → 0 °C
1.2 Reagents: Tetrabutylammonium fluoride ,  Potassium fluoride Solvents: Methanol ;  1 h, 0 °C
1.3 Reagents: Sodium bicarbonate Solvents: Water ;  0 °C

Reference

Conjugate reduction of α,β-unsaturated aldehydes with rhodium(bisoxazolinylphenyl) catalysts

Kanazawa, Yoshinori; Nishiyama, Hisao, Synlett, 2006, (19), 3343-3345

Production Method 8

5467-74-3

80793-25-5

Reaction Conditions

1.1 Reagents: Silver carbonate Catalysts: 2,9-Dimethyl-1,10-phenanthroline ,  Palladium diacetate Solvents: Acetonitrile ;  24 h, 60 °C

Reference

Ligated Regioselective PdII Catalysis to Access β-Aryl-Bearing Aldehydes, Ketones, and β-Keto Esters

Vellakkaran, Mari; Andappan, Murugaiah M. S.; Kommu, Nagaiah, European Journal of Organic Chemistry, 2012, 2012(25), 4694-4698

Production Method 9

15451-32-8

80793-25-5

Reaction Conditions

1.1 Reagents: Triphenylphosphine ,  Ozone Solvents: Dichloromethane ;  2 h, -78 °C

Reference

Radical-mediated direct C-H amination of arenes with secondary amines

Cosgrove, Sebastian C.; Plane, John M. C.; Marsden, Stephen P., Chemical Science, 2018, 9(32), 6647-6652

Production Method 10

25574-11-2

80793-25-5

Reaction Conditions

1.1 Reagents: Dess-Martin periodinane Solvents: Dichloromethane ;  rt; overnight, rt

Reference

Photocatalytic Reductive Radical-Polar Crossover for a Base-Free Corey-Seebach Reaction

Donabauer, Karsten; Murugesan, Kathiravan; Rozman, Ursa; Crespi, Stefano; Koenig, Burkhard, Chemistry - A European Journal, 2020, 26(57), 12945-12950

Production Method 11

80793-25-5

Reaction Conditions

1.1 Reagents: Sodium acetate Catalysts: Tetrabutylammonium bromide ,  Palladium chloride ;  24 h, 130 °C

Reference

Heck arylation of allyl alcohol catalyzed by Pd(0) nanoparticle

Tarnowicz, Stanislawa; Alsalahi, Waleed; Mieczynska, Ewa; Trzeciak, Anna M., Tetrahedron, 2017, 73(38), 5605-5612

Production Method 12

445483-71-6

80793-25-5

Reaction Conditions

1.1 Reagents: Zirconocene chloride hydride Solvents: Tetrahydrofuran ;  30 min, rt; 1 min, rt
1.2 Reagents: Water Solvents: Hexane

Reference

Mild conversion of tertiary amides to aldehydes using Cp2Zr(H)Cl (Schwartz's reagent)

Leighty, Matthew W.; Spletstoser, Jared T.; Georg, Gunda I., Organic Syntheses, 2011, 88, 427-437

3-(4-bromophenyl)propanal Raw materials

• 3-(4-Bromophenyl)propan-1-ol
• (4-bromophenyl)boronic acid
• 3-(4-Bromophenyl)-N,N-diethylpropanamide
• 4-Bromocinnamaldehyde
• 4-(4-Bromophenyl)-1-butene
• 1-Bromo-4-iodobenzene
• 2-2-(4-bromophenyl)ethyl-1,3-dioxolane

3-(4-bromophenyl)propanal Preparation Products

• 3-(4-bromophenyl)propanal (80793-25-5)

• 1. Elusive 2-aminofuran Diels–Alder substrates for a straightforward synthesis of polysubstituted anilines?
  Ana G. Neo,Ana Bornadiego,Jesús Díaz,Stefano Marcaccini,Carlos F. Marcos Org. Biomol. Chem., 2013,11, 6546-6555
• 2. Evidence of rutile-to-anatase photo-induced electron transfer in mixed-phase TiO2 by solid-state NMR spectroscopy?
  Weili Dai,Guangjun Wu,Michael Hunger Chem. Commun., 2015,51, 13779-13782
• 3. Evolution of dealloying induced strain in nanoporous gold crystals?
  Ross Harder,David C. Dunand,Ian McNulty Nanoscale, 2017,9, 5686-5693
• 4. Enabling stable MnO2 matrix for aqueous zinc-ion battery cathodes?
  Yiding Jiao,Liqun Kang,Jasper Berry-Gair,Kit McColl,Jianwei Li,Haobo Dong,Hao Jiang,Ryan Wang,Furio Corà,Dan J. L. Brett,Ivan P. Parkin J. Mater. Chem. A, 2020,8, 22075-22082
• 5. Fe3O4 nanoclusters highly dispersed on a porous graphene support as an additive for improving the hydrogen storage properties of LiBH4?
  Guang Xu,Wei Zhang,Ying Zhang,Xiaoxia Zhao,Ping Wen,Di Ma RSC Adv., 2018,8, 19353-19361

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Bromobenzenes
• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Halobenzenes Bromobenzenes

• 89201-84-3(4-(4-Bromophenyl)butan-2-one)
• 595610-18-7(2,5-HEXANEDIONE, 1-(4-BROMOPHENYL)-)
• 3186-22-9(1-(4-bromophenyl)acetone)
• 3506-70-5(4-(3-Bromophenyl)-2-butanone)
• 107408-16-2(3-(2-Bromo-phenyl)-propionaldehyde)
• 6186-22-7(1-(4-Bromophenyl)propan-2-one)
• 210115-30-3(3-(3-Bromophenyl)propanal)
• 200065-00-5(2-Hexanone, 1-(4-bromophenyl)-)
• 528577-33-5(BENZENEPROPANAL, 3,5-DIBROMO-)
• 8072-93-3(3-(4-Bromophenyl)propanal)