Production Method 1

51065-76-0

80537-07-1

Reaction Conditions

1.1 Reagents: Sodium hydroxide Solvents: Methanol ,  Water ;  rt → 80 °C
1.2 Reagents: Hydrochloric acid Solvents: Water

Reference

Development of Structurally Diverse N-Heterocyclic Carbene Ligands via Palladium-Copper-Catalyzed Decarboxylative Arylation of Pyrazolo[1,5-a]pyridine-3-carboxylic Acid

Alam, Khyarul; et al, Advanced Synthesis & Catalysis, 2016, 358(16), 2661-2670

Production Method 2

637-44-5

792875-56-0

80537-07-1

Reaction Conditions

1.1 Reagents: 4-Benzyloxybenzyl bromide (bromo-Wang resin-bound) ,  Diisopropylethylamine ,  Cesium iodide Solvents: Dimethylformamide ;  72 h, rt
1.2 Reagents: Potassium carbonate Solvents: Dimethylformamide ;  20 - 40 h, rt
1.3 Reagents: Trifluoroacetic acid Solvents: Dichloromethane ;  2 h, rt; overnight, rt

Reference

Solid-Phase Synthesis of Pyrazolopyridines from Polymer-Bound Alkyne and Azomethine Imines

Harju, Kirsi; et al, Journal of Combinatorial Chemistry, 2006, 8(3), 344-349

2-Phenylpyrazolo[1,5-a]pyridine-3-carboxylic acid Raw materials

• 2-Phenyl-pyrazolo1,5-apyridine-3-carboxylic Acid Ethyl Ester
• Phenylpropiolic acid
• 1(2H)-PYRIDINAMINE

2-Phenylpyrazolo[1,5-a]pyridine-3-carboxylic acid Preparation Products

• 2-Phenylpyrazolo[1,5-a]pyridine-3-carboxylic acid (80537-07-1)

• 1. Excess electrons in lithium–ethylamine solutions—density, electrical conductivity and EPR studies
  Phys. Chem. Chem. Phys., 1999,1, 3561-3565
• 2. Fate of Sb(v) and Sb(iii) species along a gradient of pH and oxygen concentration in the Carnoulès mine waters (Southern France)
  Eléonore Resongles,Corinne Casiot,Fran?oise Elbaz-Poulichet,Rémi Freydier,Odile Bruneel,Christine Piot,Sophie Delpoux,Aurélie Volant,Angélique Desoeuvre Environ. Sci.: Processes Impacts, 2013,15, 1536-1544
• 3. Enantio- & chemo-selective preparation of enantiomerically enriched aliphatic nitro alcohols using Candida parapsilosis ATCC 7330
  Sowmyalakshmi Venkataraman RSC Adv., 2015,5, 73807-73813
• 4. Dissociative dynamics of O2 on Ag(110)?
  Ivor Lon?ari? Phys. Chem. Chem. Phys., 2015,17, 9436-9445
• 5. Evidence for the intrinsic nature of band-gap states electrochemically observed on atomically flat TiO2(110) surfaces?
  Shintaro Takata,Yoshihiro Miura Phys. Chem. Chem. Phys., 2014,16, 24784-24789

Comprehensive Overview of 2-Phenylpyrazolo[1,5-a]pyridine-3-carboxylic acid (CAS No. 80537-07-1)

2-Phenylpyrazolo[1,5-a]pyridine-3-carboxylic acid (CAS No. 80537-07-1) is a heterocyclic organic compound with a unique structural framework, combining pyrazolo[1,5-a]pyridine and phenyl moieties. This compound has garnered significant attention in pharmaceutical and materials science research due to its versatile applications. Its molecular structure features a pyrazolo[1,5-a]pyridine core, which is known for its electron-rich properties, making it a valuable scaffold in drug discovery and optoelectronic materials.

In recent years, the demand for 2-Phenylpyrazolo[1,5-a]pyridine-3-carboxylic acid has surged, particularly in the context of AI-driven drug discovery and green chemistry. Researchers are increasingly exploring its potential as a building block for small-molecule inhibitors and fluorescence probes, aligning with the growing trend of precision medicine and sustainable synthesis. The compound's CAS No. 80537-07-1 is frequently searched in academic databases, reflecting its relevance in cutting-edge studies.

The synthesis of 2-Phenylpyrazolo[1,5-a]pyridine-3-carboxylic acid typically involves multi-step reactions, including cyclization and carboxylation processes. Its carboxylic acid functional group allows for further derivatization, enabling the creation of esters, amides, and other derivatives with tailored properties. This adaptability makes it a favorite among chemists working on high-throughput screening and combinatorial chemistry.

From an industrial perspective, 80537-07-1 is often discussed in forums focusing on scalable synthesis and cost-effective production. Companies are investing in optimizing its manufacturing processes to meet the rising demand from the pharmaceutical and agrochemical sectors. Additionally, its potential role in organic light-emitting diodes (OLEDs) has sparked interest in the materials science community, where researchers are investigating its photophysical properties.

Environmental and regulatory considerations are also critical when discussing 2-Phenylpyrazolo[1,5-a]pyridine-3-carboxylic acid. The compound's biodegradability and toxicity profile are under scrutiny, especially in light of the European Chemicals Agency (ECHA) guidelines and REACH compliance. These factors are increasingly influencing procurement decisions in the fine chemicals market.

In summary, 2-Phenylpyrazolo[1,5-a]pyridine-3-carboxylic acid (CAS No. 80537-07-1) represents a multifaceted compound with broad applications across drug development, materials engineering, and sustainable chemistry. Its structural uniqueness and functional versatility continue to drive innovation, making it a subject of ongoing research and commercial interest.

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