Production Method 1

56-09-7

80466-56-4

Reaction Conditions

1.1 Reagents: Sulfuric acid ,  Potassium nitrate Solvents: Water ;  2 h, rt

Reference

Syntheses of 2-amino-4,6-dichloro-5-nitropyrimidine and 2-amino-4,5,6-trichloropyrimidine: an unusual aromatic substitution

Lopez, Sergio; et al, Tetrahedron Letters, 2009, 50(44), 6022-6024

Production Method 2

2854-16-2

100-52-7

80466-56-4

Reaction Conditions

1.1 -
2.1 -
3.1 Reagents: Hydrogen bromide

Reference

Pterins. VII. Preparation of 6,6-dimethyl-5,6,7,8-tetrahydropterin hydrochloride

Armarego, Wilfred L. F.; et al, Australian Journal of Chemistry, 1981, 34(9), 1921-33

Production Method 3

603-67-8

113-00-8

463-79-6

80466-56-4

Reaction Conditions

1.1 Reagents: Sodium ethoxide Solvents: Ethanol
1.2 Reagents: Hydrochloric acid Solvents: Water

Reference

The synthesis and chlorination of some pyrimidin-4-ols having 5-nitrogen functionality

Harnden, Michael R.; et al, Australian Journal of Chemistry, 1990, 43(1), 47-53

Production Method 4

80466-52-0

80466-56-4

Reaction Conditions

1.1 Reagents: Hydrogen bromide

Reference

Pterins. VII. Preparation of 6,6-dimethyl-5,6,7,8-tetrahydropterin hydrochloride

Armarego, Wilfred L. F.; et al, Australian Journal of Chemistry, 1981, 34(9), 1921-33

Production Method 5

1007-99-4

80466-51-9

80466-56-4

Reaction Conditions

1.1 -
2.1 Reagents: Hydrogen bromide

Reference

Pterins. VII. Preparation of 6,6-dimethyl-5,6,7,8-tetrahydropterin hydrochloride

Armarego, Wilfred L. F.; et al, Australian Journal of Chemistry, 1981, 34(9), 1921-33

2-Amino-4,6-dihydroxy-5-nitropyrimidine Raw materials

• Diethyl 2-Nitromalonate
• 1-Amino-2-methylpropan-2-ol
• Guanidine
• 2-Amino-4,6-dihydroxypyrimidine
• 4(3H)-Pyrimidinone, 2-amino-6-[(2-hydroxy-2-methylpropyl)(phenylmethyl)amino]-5-nitro-
• Benzaldehyde
• 2-amino-6-chloro-5-nitropyrimidin-4-ol
• 1-(Benzylamino)-2-methylpropan-2-OL
• Carbonic acid

2-Amino-4,6-dihydroxy-5-nitropyrimidine Preparation Products

• 2-Amino-4,6-dihydroxy-5-nitropyrimidine (80466-56-4)

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Comprehensive Overview of 2-Amino-4,6-dihydroxy-5-nitropyrimidine (CAS No. 80466-56-4)

2-Amino-4,6-dihydroxy-5-nitropyrimidine (CAS No. 80466-56-4) is a specialized organic compound belonging to the pyrimidine family. This compound has garnered significant attention in recent years due to its unique chemical properties and potential applications in pharmaceuticals, agrochemicals, and material science. Researchers and industry professionals are increasingly exploring its synthesis, reactivity, and utility in various fields, making it a topic of interest in both academic and industrial settings.

The molecular structure of 2-Amino-4,6-dihydroxy-5-nitropyrimidine features a pyrimidine ring substituted with amino, hydroxy, and nitro functional groups. These functional groups contribute to its distinct chemical behavior, enabling it to participate in a wide range of reactions. For instance, the presence of the nitro group makes it a valuable intermediate in the synthesis of more complex molecules, while the amino and hydroxy groups enhance its solubility and reactivity in aqueous environments.

In the pharmaceutical industry, 2-Amino-4,6-dihydroxy-5-nitropyrimidine is often investigated for its potential as a building block in drug discovery. Its structural motifs are commonly found in bioactive molecules, including antiviral and antibacterial agents. Recent studies have highlighted its role in the development of novel therapeutics, particularly in the context of emerging infectious diseases. This aligns with the growing public interest in antiviral compounds and drug development, which are frequently searched topics in scientific databases and AI-driven platforms.

Beyond pharmaceuticals, this compound has applications in agrochemicals. Its derivatives are explored for their herbicidal and pesticidal properties, addressing the global demand for sustainable agriculture solutions. With the increasing focus on green chemistry and eco-friendly pesticides, researchers are keen to optimize the synthesis and application of such compounds to minimize environmental impact.

The synthesis of 2-Amino-4,6-dihydroxy-5-nitropyrimidine typically involves nitration and hydroxylation reactions, followed by purification steps to achieve high purity. Advances in synthetic methodologies have improved the yield and efficiency of its production, making it more accessible for research and industrial use. These developments are often discussed in forums and publications focusing on organic synthesis and chemical engineering, reflecting the compound's relevance in modern chemistry.

From a material science perspective, the compound's ability to form stable complexes with metals and other organic molecules opens doors to innovative applications. For example, it can be used in the design of functional materials with tailored properties for electronics or catalysis. This versatility makes it a subject of interest for researchers working on advanced materials and nanotechnology, areas that are rapidly evolving and highly searched in academic circles.

In summary, 2-Amino-4,6-dihydroxy-5-nitropyrimidine (CAS No. 80466-56-4) is a multifaceted compound with broad applications across multiple disciplines. Its unique chemical structure and reactivity profile make it a valuable tool in drug discovery, agrochemical development, and material science. As research continues to uncover new uses and optimize its synthesis, this compound is poised to remain a key player in the advancement of science and technology. For those interested in organic chemistry, pharmaceutical intermediates, or sustainable chemical solutions, this compound offers a wealth of opportunities for exploration and innovation.

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