Production Method 1

591-31-1

80410-57-7

Reaction Conditions

1.1 Reagents: Sulfuric acid ,  Nitric acid ;  -10 °C; 1 h, -10 °C; -10 °C → rt; 1 h, rt

Reference

Dicyanovinyl-substituted J147 analogue inhibits oligomerization and fibrillation of β-amyloid peptides and protects neuronal cells from β-amyloid-induced cytotoxicity

Kim, Kyoungdo; et al, Organic & Biomolecular Chemistry, 2015, 13(37), 9564-9569

Production Method 2

100-83-4

80410-57-7

Reaction Conditions

1.1 Reagents: Nitric acid Solvents: Acetic acid ,  Water ;  3 h, rt → 0 °C
2.1 Reagents: Potassium carbonate Solvents: Dimethylformamide ;  5 h, 0 °C

Reference

Chemoselective reduction and self-immolation based FRET probes for detecting hydrogen sulfide in solution and in cells

Chen, Bifeng; et al, Organic & Biomolecular Chemistry, 2014, 12(30), 5629-5633

Production Method 3

80866-88-2

80410-57-7

Reaction Conditions

1.1 Reagents: Dipyridinium dichromate Solvents: Dichloromethane

Reference

Synthesis and biological evaluation of aryl azide derivatives of combretastatin A-4 as molecular probes for tubulin

Pinney, K. G.; et al, Bioorganic & Medicinal Chemistry, 2000, 8(10), 2417-2425

Production Method 4

704-13-2

80410-57-7

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Dimethylformamide ;  rt; overnight, rt

Reference

Discovery of a Tetrahydrobenzisoxazole Series of γ-Secretase Modulators

Zhao, Zhiqiang ; et al, ACS Medicinal Chemistry Letters, 2017, 8(10), 1002-1006

Production Method 5

23145-65-5

80410-57-7

Reaction Conditions

1.1 Reagents: Oxygen Solvents: Dimethyl sulfoxide ;  24 h

Reference

Catalyst/Additive Free Oxidation of Benzyl Bromides to Benzaldehydes

Aman, Hasil ; et al, ChemistrySelect, 2020, 5(47), 15015-15019

Production Method 6

591-31-1

80410-57-7

Reaction Conditions

Reference

Imidazol-5-one as an Acceptor in Donor-Acceptor Cyclopropanes: Cycloaddition with Aldehydes

Mikhaylov, Andrey A. ; et al, Organic Letters, 2020, 22(7), 2740-2745

Production Method 7

67579-92-4

80410-57-7

Reaction Conditions

Reference

Arenecarbaldehydes: synthesis by reduction

Ditrich, K., Science of Synthesis, 2007, 25, 563-574

Production Method 8

5081-36-7

80410-57-7

Reaction Conditions

1.1 Reagents: (Dimethyl sulfide)trihydroboron Solvents: Tetrahydrofuran ;  rt; 3 h, 60 °C
2.1 Reagents: Manganese oxide (MnO2) Solvents: Dichloromethane ;  16 h, rt

Reference

Affinity-Driven Covalent Modulator of the Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) Cascade

Chern, Jeffy ; et al, Angewandte Chemie, 2018, 57(24), 7040-7045

3-Methoxy-4-nitrobenzaldehyde Raw materials

• 3-Hydroxy-4-nitrobenzaldehyde
• 3-Hydroxybenzaldehyde
• 3-Methoxy-4-nitrobenzoic acid
• 4-(Bromomethyl)-2-methoxy-1-nitrobenzene
• Benzoyl chloride, 3-methoxy-4-nitro-
• (3-methoxy-4-nitrophenyl)methanol
• 3-Methoxybenzaldehyde

3-Methoxy-4-nitrobenzaldehyde Preparation Products

• 3-Methoxy-4-nitrobenzaldehyde (80410-57-7)

• 1. An investigation of the electrochemical delithiation process of carbon coated α-Fe2O3nanoparticles
  Adrian Brandt,Florian Winter,Sebastian Klamor,Frank Berkemeier,Jatinkumar Rana,Rainer P?ttgen,Andrea Balducci J. Mater. Chem. A, 2013,1, 11229-11236
• 2. Aggregation of biologically important peptides and proteins: inhibition or acceleration depending on protein and metal ion concentrations
  Benjamin Gabriel Poulson,Kacper Szczepski,Joanna Izabela Lachowicz,Lukasz Jaremko,Abdul-Hamid Emwas,Mariusz Jaremko RSC Adv., 2020,10, 215-227
• 3. Aggregated-fluorescent detection of PFAS with a simple chip
  Cheng Fang,Jinjian Wu,Zahra Sobhani,Md. Al Amin,Youhong Tang Anal. Methods, 2019,11, 163-170
• 4. An algal process treatment combined with the Fenton reaction for high concentrations of amoxicillin and cefradine
  Haitao Li,Yu Pan,Zhizhi Wang,Shan Chen,Ruixin Guo,Jianqiu Chen RSC Adv., 2015,5, 100775-100782
• 5. An anti-leakage liquid metal thermal interface material
  Kaiyuan Huang,Wangkang Qiu,Meilian Ou,Xiaorui Liu,Zenan Liao,Sheng Chu RSC Adv., 2020,10, 18824-18829

Comprehensive Overview of 3-Methoxy-4-nitrobenzaldehyde (CAS No. 80410-57-7): Properties, Applications, and Industry Insights

3-Methoxy-4-nitrobenzaldehyde (CAS No. 80410-57-7) is a versatile organic compound widely used in pharmaceutical, agrochemical, and specialty chemical industries. This nitro-substituted benzaldehyde derivative features a methoxy group at the 3-position and a nitro group at the 4-position, imparting unique reactivity for heterocyclic synthesis and intermediate applications. Its molecular formula (C₈H₇NO₄) and molar mass (181.15 g/mol) make it a critical building block for fine chemical manufacturing.

The compound's yellow crystalline powder form exhibits a melting point range of 98-102°C, with solubility in polar organic solvents like ethanol and dimethyl sulfoxide (DMSO). Researchers value its electron-withdrawing nitro group for facilitating nucleophilic aromatic substitution reactions, while the methoxy group enhances solubility and directs subsequent functionalization. Recent studies highlight its role in developing non-linear optical materials and pharmaceutical intermediates, aligning with growing interest in sustainable synthesis methods.

In pharmaceutical applications, 3-Methoxy-4-nitrobenzaldehyde serves as a precursor for antimicrobial agents and central nervous system (CNS) drugs. The compound's structural features enable the construction of benzimidazole derivatives with potential biological activity. Industry reports indicate rising demand for this intermediate in generic drug production, particularly for medications targeting metabolic disorders. Its use in catalyzed cross-coupling reactions has gained attention in green chemistry initiatives, addressing environmental concerns in chemical manufacturing.

The agrochemical sector utilizes 80410-57-7 for synthesizing herbicide intermediates and plant growth regulators. The nitro group's reactivity allows for efficient transformation into amino derivatives, which are crucial for developing crop protection agents. Recent patent literature reveals innovative applications in controlled-release formulations, responding to the agricultural industry's need for precision delivery systems. Analytical studies demonstrate the compound's stability under standard storage conditions (room temperature, protected from light), making it suitable for global supply chains.

From a technical perspective, 3-Methoxy-4-nitrobenzaldehyde exhibits characteristic FT-IR absorption bands at 1685 cm^-1 (C=O stretch) and 1520 cm^-1 (NO₂ asymmetric stretch), with H-NMR signals at δ 10.4 ppm (aldehyde proton) and δ 7.5-8.1 ppm (aromatic protons). Quality control specifications typically require ≥98% purity by HPLC analysis, with strict limits on heavy metal content for pharmaceutical-grade material. Modern process optimization techniques have improved synthetic yields through microwave-assisted reactions and continuous flow chemistry approaches.

Market analysis shows increasing interest in 80410-57-7 from emerging economies developing their pharmaceutical API industries. Regulatory compliance remains crucial, with manufacturers providing REACH registration dossiers and GMP certification documentation. The compound's structure-activity relationship continues to inspire research into multi-target drug design, particularly in neurodegenerative disease research. Environmental fate studies confirm its biodegradability under aerobic conditions, supporting its use in eco-friendly chemical processes.

Recent scientific literature highlights novel applications of 3-Methoxy-4-nitrobenzaldehyde in material science, including its use as a monomer for conducting polymers and coordination complexes with transition metals. The compound's electron-deficient aromatic system makes it valuable for developing organic semiconductors and photovoltaic materials. These applications align with global trends toward renewable energy technologies and smart materials development.

Quality assurance protocols for CAS 80410-57-7 emphasize spectroscopic characterization (including UV-Vis and mass spectrometry) alongside traditional wet chemistry methods. The compound's structure-property relationships are frequently studied using computational chemistry tools, particularly density functional theory (DFT) calculations predicting its behavior in catalytic systems. These advanced analytical approaches support the compound's expanding role in high-value chemical production.

Supply chain professionals note stable availability of 3-Methoxy-4-nitrobenzaldehyde from major chemical producers, with technical and pharmaceutical grades meeting diverse industry requirements. Current research explores bio-catalytic production methods using engineered enzymes, reflecting the chemical industry's shift toward biotechnology solutions. The compound's regioselective reactivity continues to make it valuable for complex molecule assembly in both academic and industrial settings.

• 704-13-2(3-Hydroxy-4-nitrobenzaldehyde)
• 31680-08-7(4-Methoxy-3-nitrobenzaldehyde)
• 38512-82-2(5-Methyl-2-nitroanisole)
• 54291-82-6(Benzaldehyde, 4-(5-formyl-2-hydroxyphenoxy)-3-nitro-)
• 6635-20-7(5-Nitrovanillin)
• 53055-05-3(3-Methoxy-2-nitrobenzaldehyde)
• 22106-39-4(1-(3-methoxy-4-nitrophenyl)-1-ethanone)
• 22027-96-9(3,4-Dimethoxy-5-nitrobenzaldehyde)
• 15962-63-7(4-(4-Methoxyphenoxy)-3-nitrobenzaldehyde)
• 2363-11-3(3-(2,4-Dinitrophenoxy)benzaldehyde)