Production Method 1

1128-61-6

80290-18-2

Reaction Conditions

1.1 Reagents: Aluminum chloride ,  Bromine Solvents: 1,2-Dichloroethane ;  10 - 15 min, 20 - 25 °C; 25 °C → 60 °C; 3 h, 50 - 60 °C; 60 °C → 0 °C
1.2 Reagents: Sodium hydroxide Solvents: 1,2-Dichloroethane ,  Water

Reference

Structure-Activity Relationship Studies with Tetrahydroquinoline Analogs as EPAC Inhibitors

Sonawane, Yogesh A. ; et al, ACS Medicinal Chemistry Letters, 2017, 8(11), 1183-1187

Production Method 2

1128-61-6

80290-18-2

Reaction Conditions

1.1 Reagents: Sulfuric acid ,  Bromine ,  Silver sulfate Solvents: Water

Reference

Studies on antibacterial agents. I. Synthesis of substituted 6,7-dihydro-1-oxo-1H,5H-benzo[i,j]-quinolizine-2-carboxylic acids

Ishikawa, Hiroshi; et al, Chemical & Pharmaceutical Bulletin, 1989, 37(8), 2103-8

5-bromo-6-fluoro-2-methylquinoline Raw materials

• 6-Fluoro-2-methylquinoline

5-bromo-6-fluoro-2-methylquinoline Preparation Products

• 5-bromo-6-fluoro-2-methylquinoline (80290-18-2)

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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Quinolines and derivatives Haloquinolines

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• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)