Production Method 1

14432-12-3

800402-12-4

909036-46-0

1171919-00-8

Reaction Conditions

1.1 Reagents: Potassium acetate ,  Iodine chloride Solvents: Water ;  4 d, pH 5.5, 75 °C
1.2 Reagents: Sodium carbonate Solvents: Water ;  pH 7 - 8, rt
1.3 Reagents: Sodium thiosulfate Solvents: Water ;  rt

Reference

Palladium-Catalyzed Synthesis of 2,3-Disubstituted 5-Azaindoles via Heteroannulation Reaction and of 2-Substituted 5-Azaindoles through Domino Sila-Sonogashira/5-Endo Cyclization

Livecchi, Marion; Calvet, Geraldine; Schmidt, Frederic, Journal of Organic Chemistry, 2012, 77(11), 5006-5016

Production Method 2

14432-12-3

800402-12-4

Reaction Conditions

1.1 Reagents: N-Iodosuccinimide Solvents: Acetonitrile ;  overnight, 82 °C

Reference

The Synthesis of 3,3-Dimethyl Aza- and Diazaindolines Using a Palladium-Catalysed Intramolecular Reductive Cyclisation

Day, James E. H.; Frederickson, Martyn; Hogg, Colin; Johnson, Christopher N.; Meek, Alistair; et al, Synlett, 2015, 26(18), 2570-2574

Production Method 3

14432-12-3

800402-12-4

909036-46-0

Reaction Conditions

1.1 Reagents: Potassium acetate ,  Iodine chloride Solvents: Acetic acid ;  60 - 70 °C

Reference

Potent 4-amino-5-azaindole factor VIIa inhibitors

Hu, Huiyong; Kolesnikov, Aleksandr; Riggs, Jennifer R.; Wesson, Kieron E.; Stephens, Robin; et al, Bioorganic & Medicinal Chemistry Letters, 2006, 16(17), 4567-4570

Production Method 4

14432-12-3

800402-12-4

909036-46-0

1171919-00-8

Reaction Conditions

1.1 Reagents: Potassium acetate ,  Iodine chloride Solvents: Acetic acid ;  4 h, rt → 70 °C
1.2 Reagents: Sodium bicarbonate Solvents: Water ;  neutralized

Reference

Synthesis, crystal structure, molecular docking and antimicrobial evaluation of new pyrrolo[3,2-c]pyridine derivatives

Jose, Gilish; Suresha Kumara, T. H.; Nagendrappa, Gopalpur; Sowmya, H. B. V.; Jasinski, Jerry P.; et al, Journal of Molecular Structure, 2015, 1081, 85-95

Production Method 5

14432-12-3

800402-12-4

909036-46-0

1171919-00-8

Reaction Conditions

1.1 Reagents: Potassium acetate ,  Iodine chloride Solvents: Acetic acid ;  4 h, rt → 70 °C
1.2 Reagents: Sodium bicarbonate Solvents: Water ;  neutralized

Reference

New polyfunctional imidazo[4,5-C]pyridine motifs: Synthesis, crystal studies, docking studies and antimicrobial evaluation

Jose, Gilish; Suresha Kumara, T. H.; Nagendrappa, Gopalpur; Sowmya, H. B. V.; Jasinski, Jerry P.; et al, European Journal of Medicinal Chemistry, 2014, 77, 288-297

Production Method 6

14432-12-3

800402-12-4

909036-46-0

1171919-00-8

Reaction Conditions

1.1 Reagents: Potassium acetate ,  Iodine chloride Solvents: Acetic acid ;  4 h, 70 °C

Reference

Synthesis, molecular docking, antimycobacterial and antimicrobial evaluation of new pyrrolo[3,2-c]pyridine Mannich bases

Jose, Gilish ; Suresha Kumara, Tholappanavara H.; Sowmya, Haliwana B. V.; Sriram, Dharmarajan; Guru Row, Tayur N.; et al, European Journal of Medicinal Chemistry, 2017, 131, 275-288

Production Method 7

14432-12-3

800402-12-4

Reaction Conditions

1.1 Reagents: Potassium acetate ,  Iodine chloride Solvents: Acetic acid ;  3 h, 80 °C

Reference

Discovery of 3-Alkoxyamino-5-(pyridin-2-ylamino)pyrazine-2-carbonitriles as Selective, Orally Bioavailable CHK1 Inhibitors

Lainchbury, Michael; Matthews, Thomas P.; McHardy, Tatiana; Boxall, Kathy J.; Walton, Michael I.; et al, Journal of Medicinal Chemistry, 2012, 55(22), 10229-10240

Production Method 8

14432-12-3

800402-12-4

Reaction Conditions

1.1 Reagents: Potassium acetate Solvents: Pentane ;  5 h, 70 °C; 70 °C → rt
1.2 Reagents: Sodium bicarbonate Solvents: Ethyl acetate ,  Water ;  rt

Reference

Multiparameter Lead Optimization to Give an Oral Checkpoint Kinase 1 (CHK1) Inhibitor Clinical Candidate: (R)-5-((4-((Morpholin-2-ylmethyl)amino)-5-(trifluoromethyl)pyridin-2-yl)amino)pyrazine-2-carbonitrile (CCT245737)

Osborne, James D.; Matthews, Thomas P.; McHardy, Tatiana; Proisy, Nicolas; Cheung, Kwai-Ming J.; et al, Journal of Medicinal Chemistry, 2016, 59(11), 5221-5237

Production Method 9

14432-12-3

800402-12-4

Reaction Conditions

1.1 Reagents: Iodine ,  Sulfuric acid, silver(2+) salt (1:1) Solvents: Ethanol ;  72 h, rt

Reference

Discovery and optimization of indoles and 7-azaindoles as Rho kinase (ROCK) inhibitors (part-I)

Chowdhury, Sarwat; Sessions, E. Hampton; Pocas, Jennifer R.; Grant, Wayne; Schroeter, Thomas; et al, Bioorganic & Medicinal Chemistry Letters, 2011, 21(23), 7107-7112

2-chloro-5-iodopyridin-4-amine Raw materials

• 2-chloropyridin-4-amine

2-chloro-5-iodopyridin-4-amine Preparation Products

• 2-Chloro-3-iodopyridin-4-amine (909036-46-0)
• 2-Chloro-3,5-diiodopyridin-4-amine (1171919-00-8)
• 2-chloro-5-iodopyridin-4-amine (800402-12-4)

• 1. An algal process treatment combined with the Fenton reaction for high concentrations of amoxicillin and cefradine
  Haitao Li,Yu Pan,Zhizhi Wang,Shan Chen,Ruixin Guo,Jianqiu Chen RSC Adv., 2015,5, 100775-100782
• 2. An artificial photosynthetic system for photoaccumulation of two electrons on a fused dipyridophenazine (dppz)–pyridoquinolinone ligand?
  Philipp Traber,Stephan Kupfer,Stefanie Gr?fe,Isabelle Baussanne,Martine Demeunynck,Jean-Marie Mouesca,Serge Gambarelli,Vincent Artero,Murielle Chavarot-Kerlidou Chem. Sci., 2018,9, 4152-4159
• 3. Acetyl protected thiol methacrylic polymers as effective ligands to keep quantum dots in luminescent standby mode?
  Marta Liras,Isabel Quijada-Garrido,Marta Palacios-Cuesta,Sonia Mu?oz-Durieux,Olga García Polym. Chem., 2014,5, 433-442
• 4. An antimonate pyrochlore (H1.23Sr0.45SbO3.48) for photocatalytic oxidation of benzene: effective oxygen usage and excellent activity?
  Jing Chen,Yu Shao,Danzhen Li J. Mater. Chem. A, 2017,5, 937-941
• 5. Alumina grafted SBA-15 sustainable bifunctional catalysts for direct cross-coupling of benzylic alcohols to diarylmethanes?
  Chandran Rajendran,Govindaswamy Satishkumar,Charlotte Lang,Eric M. Gaigneaux Catal. Sci. Technol., 2020,10, 2583-2592

• 1447227-69-1(2-Chloro-5-iodo-N-propan-2-ylpyridin-4-amine)
• 1171919-00-8(2-Chloro-3,5-diiodopyridin-4-amine)
• 909036-46-0(2-Chloro-3-iodopyridin-4-amine)
• 1363380-53-3(2-chloro-5-iodopyridine-3,4-diamine)
• 8002-24-2(2-Chloro-5-iodo-4-pyridinamine)
• 1235873-11-6(2,6-Dichloro-3-iodopyridin-4-amine)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)