Cas no 80012-43-7 (Epinastine)

Epinastine structure
Epinastine structure
Product Name:Epinastine
CAS No:80012-43-7
MF:C16H15N3
MW:249.310403108597
MDL:MFCD00865648
CID:60163
PubChem ID:3241
Update Time:2025-09-22

Epinastine Chemical and Physical Properties

Names and Identifiers

    • Epinastine
    • 3-amino-9,13b-dihydro-1h-dibenz[c,f]imidazo[1,5-a]azepine
    • Epinastine base
    • WAL801
    • 3-Amino-9,13b-dihydro-1H-dibenzo[c,f]imidazo[1,5-a]azepine
    • 9,13b-Dihydro-1H-dibenz[c,f]imidazo[1,5-a]azepin-3-amine
    • Flurinol(R)
    • Epinastina
    • Epinastinum
    • Epinastinum [Latin]
    • Epinastina [Spanish]
    • (+-)-Epinastine
    • Elestat
    • Epinastine [INN]
    • WAL 801
    • Epinastine (INN)
    • 9,13b-dihydro-1H-dibenzo[c,f]imidazo[1,5-a]azepin-3-amine
    • 79UN26Y71B
    • C16H15N3
    • Relestat
    • 5HDI847257
    • Purivist (
    • EC 616-785-3
    • NCGC00165791-01
    • D07900
    • 3-Amino-9,13b-dihydro-1H-dibenz(c,f)imidazo(1,5-a)azepine
    • 3-amino-9,13b-dihydro-1H-benz(c,f)imidazo(1,5a)azepine
    • NS00005464
    • FT-0630877
    • L000716
    • DTXCID8028345
    • AKOS015895203
    • Epinastine [INN:BAN]
    • 1H-Dibenz(c,f)imidazo(1,5-a)azepin-3-amino, 9,13b-dihydro-
    • BCP28446
    • Q632405
    • NCGC00165791-11
    • DTXSID2048371
    • (+/-)-Epinastine
    • UNII-Q13WX941EF
    • WAL-801
    • BDBM50131441
    • Purivist (TN)
    • AMY33372
    • MFCD00865648
    • SDCCGSBI-0633722.P001
    • EPINASTINE [VANDF]
    • DB00751
    • R06AX24
    • AS-12835
    • EX-A4762
    • Q13WX941EF
    • 2,4-diazatetracyclo[12.4.0.0^{2,6}.0^{7,12}]octadeca-1(18),3,7,9,11,14,16-heptaen-3-amine
    • 2,4-diazatetracyclo[12.4.0.02,6.07,12]octadeca-1(18),3,7,9,11,14,16-heptaen-3-amine
    • 80012-43-7
    • CHEBI:51032
    • 9,13B-DIHYDRO-1H-DIBENZ(C,F)IMIDAZO(1,5-A)AZEPIN-3-AMINE
    • A917968
    • HY-B0640
    • 9,13b-dihydro-1H-dibenzo(c,f)imidazo(1,5-a)azepin-3-amine
    • 9,13b-Dihydro-1H-dibenz(c,f)imidazo(1,5a)azepin-3-amin
    • S01GX10
    • EPINASTINE [MI]
    • CHEMBL1106
    • Epinastinum (Latin)
    • EPINASTINE [WHO-DD]
    • NCGC00165791-02
    • MRF-0000757
    • 1H-Dibenz[c,f]imidazo[1,5-a]azepin-3-amine, 9,13b-dihydro-
    • EN300-18166758
    • GTPL7176
    • Epinastin
    • Epinastinehydrochloride
    • 1H-DIBENZ(C,F)IMIDAZO(1,5-A)AZEPIN-3-AMINE, 9,13B-DIHYDRO-
    • Purivist
    • WHWZLSFABNNENI-UHFFFAOYSA-N
    • NCGC00165791-03
    • SCHEMBL18794
    • AC-24691
    • 9,13b-Dihydro-1H-dibenz[c,f]imidazo[1,5-a]azepin-3-amine (ACI)
    • (±)-Epinastine
    • Epinastine?
    • 9,13b-Dihydro-1H-dibenz[c,f]imidazo[1,5-a]azepin-3- amine
    • A12854
    • BRD-A98990573-003-01-3
    • MDL： MFCD00865648
    • Inchi： 1S/C16H15N3/c17-16-18-10-15-13-7-3-1-5-11(13)9-12-6-2-4-8-14(12)19(15)16/h1-8,15H,9-10H2,(H2,17,18)
    • InChI Key： WHWZLSFABNNENI-UHFFFAOYSA-N
    • SMILES： N1CC2N(C3C(CC4C2=CC=CC=4)=CC=CC=3)C=1N

Computed Properties

  • Exact Mass: 249.12700
  • Monoisotopic Mass: 285.103275
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 1
  • Hydrogen Bond Acceptor Count: 1
  • Heavy Atom Count: 19
  • Rotatable Bond Count: 0
  • Complexity: 378
  • Covalently-Bonded Unit Count: 2
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 1
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: 3.5
  • Topological Polar Surface Area: 41.6

Experimental Properties

  • Color/Form: 白色至黃色 結(jié)晶粉末
  • Density: 1.3±0.1 g/cm3
  • Melting Point: 200-216°C
  • Boiling Point: 428.0±55.0 °C at 760 mmHg
  • Flash Point: 212.7 °C
  • Refractive Index: 1.727
  • Solubility: 生物體外In Vitro:DMSO溶解度≥ 50 mg/mL(200.55 mM)H2O< 0.1 mg/mL(insoluble)*"≥" means soluble可溶, but saturation unknown溶解度未知.
  • PSA: 41.62000
  • LogP: 2.66770
  • pka: 11.2(at 25℃)
  • Vapor Pressure: 0.0±1.0 mmHg at 25°C

Epinastine Security Information

Epinastine Pricemore >>

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Epinastine Production Method

Production Method 1

Reaction Conditions
1.1 Solvents: Methanol ;  14 - 16 h, rt
1.2 Reagents: Sodium hydroxide Solvents: tert-Butyl methyl ether ,  Water ;  pH 10 - 11
Reference
Synthesis technology of epinastine hydrochloride
Guo, Jian-feng; Zhang, Cai-xia; Wang, Yan-li; Sun, Xin-hui; Guo, Zhen-hua, Xiandai Yaowu Yu Linchuang, 2011, 26(5), 378-380

Production Method 2

Reaction Conditions
Reference
A Modular Approach to Dibenzo-fused ε-Lactams: Palladium-Catalyzed Bridging-C-H Activation
Yu, Yinghua; Ma, Liyao; Xia, Jiajin; Xin, Luoting; Zhu, Lei; et al, Angewandte Chemie, 2020, 59(41), 18261-18266

Production Method 3

Reaction Conditions
Reference
Process for preparation of 3-amino-9,13b-dihydro-1H-dibenz[c,f]imidazo[1,5-a]azepine hydrochloride
, European Patent Organization, , ,

Epinastine Raw materials

Epinastine Preparation Products

Epinastine Suppliers

Tiancheng Chemical (Jiangsu) Co., Ltd
Gold Member
Audited Supplier Audited Supplier
(CAS:80012-43-7)依匹斯汀
Order Number:LE26858577;LE16144
Stock Status:in Stock
Quantity:25KG,200KG,1000KG
Purity:99%
Pricing Information Last Updated:Friday, 20 June 2025 12:59
Price ($):discuss personally
Suzhou Senfeida Chemical Co., Ltd
Gold Member
Audited Supplier Audited Supplier
(CAS:80012-43-7)Epinastine
Order Number:sfd4955
Stock Status:in Stock
Quantity:200kg
Purity:99.9%
Pricing Information Last Updated:Friday, 19 July 2024 14:33
Price ($):discuss personally

Epinastine Related Literature

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80012-43-7 (Epinastine) Related Products

Recommended suppliers
Tiancheng Chemical (Jiangsu) Co., Ltd
(CAS:80012-43-7)依匹斯汀
LE26858577;LE16144
Purity:99%/99%
Quantity:25KG,200KG,1000KG/25KG,200KG,1000KG
Price ($):Inquiry/Inquiry
Email
Suzhou Senfeida Chemical Co., Ltd
(CAS:80012-43-7)Epinastine
sfd4955
Purity:99.9%
Quantity:200kg
Price ($):Inquiry
Email