Production Method 1

81634-59-5

80-46-6

Reaction Conditions

1.1 Catalysts: Alumina ,  Aluminum chloride ;  3 min

Reference

Ecofriendly solvent free microwave induced organic rearrangements of alkyl phenyl ethers in dry media conditions

Easwaramurthy, M.; et al, Organic Chemistry: An Indian Journal, 2006, 2(5-6), 127-130

Production Method 2

80-46-6

Reaction Conditions

1.1 Catalysts: Benzenesulfonic acid ;  rt; rt → 120 °C; 2 h, 120 °C; 1 h, 120 °C; cooled
1.2 Reagents: Potassium carbonate Solvents: Benzene ;  neutralized

Reference

Alkylation of phenol with tert.-amyl alcohol

Saha, Manoranjan; et al, Bangladesh Journal of Scientific and Industrial Research, 2005, 40(3-4), 291-296

Production Method 3

80-46-6

Reaction Conditions

1.1 Catalysts: Hydrochloric acid ,  Iron chloride (FeCl3) Solvents: 1,2-Dichloroethane ,  Water ;  24 h, 50 °C

Reference

Synergistic Bronsted/lewis acid catalyzed aromatic alkylation with unactivated tertiary alcohols or di-tert-butylperoxide to synthesize quaternary carbon centers

Pan, Aaron; et al, ChemRxiv, 2021, 1, 1-9

Production Method 4

80-46-6

Reaction Conditions

1.1 Reagents: Sulfuric acid

Reference

Preparation of 2-methyl-2-(4-hydroxyphenyl)butane

, Poland, , ,

Production Method 5

261618-80-8

80-46-6

Reaction Conditions

1.1 Reagents: Butyllithium Solvents: Pentane
1.2 Reagents: Hydrochloric acid
1.3 Solvents: Water
1.4 Solvents: Ethyl acetate

Reference

Facile O-Deallylation of Allyl Ethers via SN2' Reaction with tert-Butyllithium

Bailey, William F.; et al, Organic Letters, 2000, 2(4), 489-491

Production Method 6

261618-80-8

80-46-6

Reaction Conditions

1.1 Catalysts: Nickel(1+), hydrotetrakis(trimethylphosphine)-, salt with 1,1,1-trifluoro-N-[(tr… Solvents: Tetrahydrofuran ;  30 min, rt
1.2 Catalysts: p-Toluenesulfonic acid ;  6 h, rt → 60 °C
1.3 Reagents: Ethyl acetate Solvents: Water

Reference

Nickel Hydride Catalyzed Cleavage of Allyl Ethers Induced by Isomerization

Kathe, Prasad M.; et al, Synlett, 2021, 32(16), 1629-1632

Production Method 7

507-36-8

80-46-6

Reaction Conditions

1.1 Solvents: 1,1,1,3,3,3-Hexafluoro-2-propanol ;  10 h, rt

Reference

HFIP-promoted para-selective alkylation of anilines and phenols with tertiary alkyl bromides

Huang, Pengcheng; et al, Organic Chemistry Frontiers, 2023, 10(10), 2476-2481

Production Method 8

80-46-6

Reaction Conditions

1.1 Catalysts: Hydrochloric acid ,  Iron chloride (FeCl3) Solvents: 1,2-Dichloroethane ,  Water ;  24 h, 50 °C

Reference

Synergistic Bronsted/Lewis acid catalyzed aromatic alkylation with unactivated tertiary alcohols or di-tert-butylperoxide to synthesize quaternary carbon centers

Pan, Aaron; et al, Chemical Science, 2022, 13(12), 3539-3548

Production Method 9

66107-29-7

80-46-6

Reaction Conditions

1.1 Reagents: Sodium isopropoxide Catalysts: Bis(1,5-cyclooctadiene)nickel ,  7H-Acenaphth[1,2-d]imidazolium, 9-[2,6-bis(diphenylmethyl)-4-methylphenyl]-7-[2,… Solvents: Cyclohexane ;  30 min, rt
1.2 12 h, rt
1.3 Reagents: Boron tribromide Solvents: Dichloromethane ;  0 °C; overnight, rt
1.4 Reagents: Ethanol

Reference

Divergent and Selective Light Alkene Cross-Coupling

Wang, Zi-Chao; et al, Angewandte Chemie, 2023, 62(45),

Production Method 10

80-46-6

Reaction Conditions

Reference

Alkylation of phenol with α-methylstyrene, propylene, butenes, isoamylene, 1-octene, and diisobutylene: heterogeneous vs. homogeneous catalysts

Chaudhuri, Basab; et al, Industrial & Engineering Chemistry Research, 1991, 30(1), 227-31

Production Method 11

80-46-6

Reaction Conditions

1.1 Reagents: Trifluoroacetic acid ,  Anisole ,  Trimethylsilyl triflate Solvents: Dichloromethane ;  22 °C

Reference

Trimethylsilyl Trifluoromethanesulfonate

Sweeney, Joseph; et al, e-EROS Encyclopedia of Reagents for Organic Synthesis, 2001, ,

Production Method 12

80-46-6

Reaction Conditions

Reference

4-Tert-amylphenol and 2,4-di-tert-amylphenol

, Japan, , ,

Production Method 13

2050-03-5

80-46-6

Reaction Conditions

1.1 Reagents: Boron tribromide Solvents: Dichloromethane ;  0 °C; overnight, rt
1.2 Reagents: Ethanol

Reference

Divergent and Selective Light Alkene Cross-Coupling

Wang, Zi-Chao; et al, Angewandte Chemie, 2023, 62(45),

Production Method 14

80-46-6

3279-27-4

Reaction Conditions

1.1 Catalysts: Zirconium oxychloride (reaction products with chlorosulfonic acid) ;  rt → 140 °C; 1 h, 139 - 141 °C

Reference

Zirconia-modified superacid UDCaT-5. An efficient and versatile catalyst for alkylation reactions under solvent-free conditions

Yadav, Ganapati D.; et al, Synthetic Communications, 2008, 38(15), 2684-2691

4-Tert-Amylphenol Raw materials

• p-tert-amylanisole
• 4-Methoxyphenyl Trifluoromethanesulfonate
• Benzene, 1-(1,1-dimethylpropyl)-4-(2-propen-1-yloxy)-
• 2-Bromo-2-methylbutane
• Benzene, (1,1-dimethylpropoxy)-

4-Tert-Amylphenol Preparation Products

• 4-Tert-Amylphenol (80-46-6)
• 2-(1,1-Dimethylpropyl)phenol (3279-27-4)

• 1. An approach towards the synthesis of novel fused nitrogen tricyclic heterocyclic scaffolds via GBB reaction?
  Sandip Gangadhar Balwe,Yeon Tae Jeong Org. Biomol. Chem., 2018,16, 1287-1296
• 2. An artificial CO-releasing metalloprotein built by histidine-selective metallation?
  Inês S. Albuquerque,Hélia F. Jeremias,Miguel Chaves-Ferreira,Dijana Matak-Vinkovic,Omar Boutureira,Carlos C. Rom?o Chem. Commun., 2015,51, 3993-3996
• 3. An aptasensor for the detection of ampicillin in milk using a personal glucose meter
  Xixi Li,Nanwei Zhu,Ruohan Li,Qinpu Zhang Anal. Methods, 2020,12, 3376-3381
• 4. An investigation into the origin of variations in photovoltaic performance using D–D–π–A and D–A–π–A triphenylimidazole dyes with a copper electrolyte?
  Govind Reddy Mol. Syst. Des. Eng., 2021,6, 779-789
• 5. An atomically efficient, highly stable and redox active Ce0.5Tb0.5Ox (3% mol.)/MgO catalyst for total oxidation of methane?
  Juan J. Sánchez,Miguel López-Haro,Juan C. Hernández-Garrido,Ginesa Blanco,Miguel A. Cauqui,José M. Rodríguez-Izquierdo,José A. Pérez-Omil,José J. Calvino,María P. Yeste J. Mater. Chem. A, 2019,7, 8993-9003

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Phenylpropanes
• Solvents and Organic Chemicals Organic Compounds Hydrocarbons

• 1173020-24-0(4-t-Octylphenol-13C6 Standard Solution (10μg/mL Acetone Solution))
• 4128-07-8(Phenol,4-(1,1,2-trimethylpropyl)-)
• 1173021-20-9(4-tert-Octylphenol-3,5-d2)
• 74385-27-6(Phenol,4,4'-(1,1,2,2-tetramethyl-1,2-ethanediyl)bis- (9CI))
• 28675-72-1(Phenol,4-(1,1,3,3-tetramethylbutyl)-, barium salt (2:1))
• 1173020-19-3(4-(3,6-Dimethyl-3-heptyl)phenol-3,5-d2 solution)
• 1173020-38-6(4-(3,6-Dimethyl-3-heptyl)phenol-13C6 Standard Solution (10μg/mL Acetone Solution))
• 141888-09-7(4,4',4''-(Propane-1,1,1-triyl)triphenol)
• 881201-77-0(4-(4-Ethyl-4-methylhexan-2-yl)phenol)
• 851401-44-0(4-(2,3,5-Trimethylhexan-2-yl)phenol)