Production Method 1

62-55-5

33142-21-1

79836-78-5

Reaction Conditions

Reference

Cyclophanes. 14. Synthesis, structure assignment, and conformational properties of [2.2](2,5)oxazolo- and thiazolophanes

Mashraqui, Sabir H.; et al, Journal of the American Chemical Society, 1982, 104(16), 4461-5

Production Method 2

62-55-5

4504-12-5

79836-78-5

Reaction Conditions

1.1 Reagents: Trifluoroacetic acid Solvents: Acetonitrile ;  3 h

Reference

A convenient synthesis of 2-substituted thiazole-5-carboxylates

Fong, Mei; et al, Australian Journal of Chemistry, 2004, 57(6), 599-604

ethyl 2-methyl-1,3-thiazole-5-carboxylate Raw materials

• Thioacetamide
• 4-Isoxazolecarboxylic acid, 2,5-dihydro-5-oxo-2-phenyl-, ethyl ester
• ethyl 2-chloro-3-oxo-propanoate

ethyl 2-methyl-1,3-thiazole-5-carboxylate Preparation Products

• ethyl 2-methyl-1,3-thiazole-5-carboxylate (79836-78-5)

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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Azoles Thiazolecarboxylic acids and derivatives
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Azoles Thiazoles Thiazolecarboxylic acids and derivatives

Comprehensive Overview of Ethyl 2-Methyl-1,3-Thiazole-5-Carboxylate (CAS No. 79836-78-5)

Ethyl 2-methyl-1,3-thiazole-5-carboxylate (CAS No. 79836-78-5) is a versatile organic compound widely utilized in pharmaceutical, agrochemical, and flavor/fragrance industries. This thiazole derivative features a carboxylate ester group, making it a valuable intermediate for synthesizing bioactive molecules. Its molecular formula, C₇H₉NO₂S, and unique structure contribute to its reactivity and applicability in diverse chemical transformations.

The growing demand for heterocyclic compounds like ethyl 2-methyl-1,3-thiazole-5-carboxylate is driven by their role in drug discovery. Researchers frequently search for "thiazole derivatives in medicinal chemistry" or "CAS 79836-78-5 applications," reflecting its relevance in developing antiviral and anti-inflammatory agents. Recent studies highlight its potential as a building block for kinase inhibitors, aligning with trends in targeted cancer therapies.

In agrochemicals, this compound addresses the rising need for "eco-friendly pesticides." Its thiazole core is pivotal in designing novel crop protection agents, a topic gaining traction due to global food security concerns. Users often inquire about "thiazole-based fungicides" or "79836-78-5 synthesis," underscoring its industrial significance.

The flavor industry leverages ethyl 2-methyl-1,3-thiazole-5-carboxylate for its aromatic properties. Searches for "food-grade thiazole compounds" or "natural flavor enhancers" correlate with its use in replicating savory notes in processed foods. This aligns with consumer trends toward clean-label ingredients and plant-based alternatives.

From a synthetic perspective, the compound’s ester functionality enables facile modifications. Chemists exploring "regioselective thiazole reactions" or "79836-78-5 derivatives" value its adaptability in nucleophilic substitutions and cross-coupling reactions. Its stability under mild conditions makes it preferable for scalable production.

Environmental and regulatory considerations are increasingly prominent. Queries like "biodegradable thiazole compounds" reflect the shift toward sustainable chemistry. Ethyl 2-methyl-1,3-thiazole-5-carboxylate meets many green chemistry metrics due to its low toxicity profile and compatibility with catalytic processes.

Analytical methods for characterizing this compound, such as GC-MS and HPLC, are frequently discussed in "CAS 79836-78-5 purity analysis" searches. Quality control protocols emphasize the importance of identifying isomers and byproducts, ensuring consistency in industrial applications.

Future research directions include exploring its role in "smart materials" and "bioelectronic interfaces," given the thiazole ring’s electron-rich nature. Such innovations could expand its utility beyond traditional sectors, catering to next-gen technologies.

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• 50680-74-5(5-Thiazolecarboxylicacid, 2-propyl-, ethyl ester)
• 912639-86-2(5-Thiazolecarboxylic acid, 2-ethynyl-, ethyl ester)
• 509083-71-0(Ethyl 2-formyl-1,3-thiazole-5-carboxylate)
• 53233-90-2(Methyl 2-methylthiazole-5-carboxylate)
• 919509-87-8(5-Thiazolecarboxylic acid, 2-[(formylamino)methyl]-, ethyl ester)