• 1. Distinct correlation between (CN2)x units and pores: a low-cost method for predesigned wide range control of micropore size of porous carbon?
  Xiaotong Feng,Lei Bian,Jie Ma,Lei Zhou,Xiayan Wang,Guangsheng Guo,Qiaosheng Pu Chem. Commun., 2019,55, 3963-3966
• 2. Establishing new scaling relations on two-dimensional MXenes for CO2 electroreduction?
  Albertus D. Handoko,Khoong Hong Khoo,Teck Leong Tan,Hongmei Jin,Zhi Wei Seh J. Mater. Chem. A, 2018,6, 21885-21890
• 3. Dissociative dynamics of O2 on Ag(110)?
  Ivor Lon?ari? Phys. Chem. Chem. Phys., 2015,17, 9436-9445
• 4. Fast synthesis of red Li3BaSrLn3(WO4)8:Eu3+ phosphors for white LEDs under near-UV excitation by a microwave-assisted solid state reaction method and photoluminescence studies
  Bo Wei,Zhenyu Liu,Chen Xie,Shu Yang,Wentao Tang,Aiwei Gu,Wing-Tak Wong,Ka-Leung Wong J. Mater. Chem. C, 2015,3, 12322-12327
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  Joseph H. Bisesi,Tara Sabo-Attwood Environ. Sci.: Nano, 2014,1, 574-583

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Diazines Pyrimidines and pyrimidine derivatives

Comprehensive Overview of 1-(pyrimidin-5-yl)ethan-1-ol (CAS No. 79691-74-0): Properties, Applications, and Industry Insights

1-(pyrimidin-5-yl)ethan-1-ol (CAS No. 79691-74-0) is a specialized organic compound featuring a pyrimidine ring linked to an ethanol moiety. This structure grants it unique chemical properties, making it valuable in pharmaceutical, agrochemical, and material science research. The compound's heterocyclic nature and hydroxyl functional group contribute to its reactivity, enabling diverse synthetic applications. Recent studies highlight its role as a building block for drug discovery, particularly in kinase inhibitors and antiviral agents.

In the context of green chemistry trends, researchers are exploring sustainable synthesis routes for 1-(pyrimidin-5-yl)ethan-1-ol. A 2023 study demonstrated its production via biocatalytic reduction, aligning with the industry's shift toward eco-friendly processes. The compound's solubility profile (moderate in polar solvents like ethanol and DMSO) makes it suitable for high-throughput screening platforms, addressing the growing demand for efficient drug discovery tools.

The structure-activity relationship (SAR) of 79691-74-0 has garnered attention in medicinal chemistry circles. Its pyrimidine core mimics nucleobases, allowing interactions with biological targets—a property leveraged in developing small-molecule therapeutics for metabolic disorders. Patent analyses reveal increasing use in precursor synthesis for kinase modulators, reflecting the oncology research boom.

From an analytical perspective, 1-(pyrimidin-5-yl)ethan-1-ol exhibits characteristic NMR peaks at 8.85 ppm (pyrimidine-H) and 4.90 ppm (hydroxyl-H), facilitating quality control. Advanced techniques like LC-MS and HPLC-UV are employed for purity assessment (>98% in commercial grades), meeting stringent requirements for pharmaceutical intermediates. Thermal analysis shows stability up to 180°C, supporting its use in high-temperature reactions.

Market intelligence indicates rising demand for 79691-74-0 in Asia-Pacific regions, driven by contract research organizations (CROs) expanding their fragment-based drug design services. The compound's cost-effectiveness compared to analogous azaindole derivatives positions it favorably for scalable production. Regulatory databases confirm its compliance with REACH and FDA guidelines for research use.

Emerging applications include metal-organic frameworks (MOFs), where its bidentate ligand capability assists in constructing porous materials for gas storage. In catalysis, derivatives of 1-(pyrimidin-5-yl)ethan-1-ol serve as chiral auxiliaries for asymmetric synthesis—a technique gaining traction in flavor & fragrance industries. Computational studies using DFT calculations predict further utility in electronic materials due to its conjugated system.

Storage recommendations for CAS 79691-74-0 emphasize protection from moisture (desiccated at 2-8°C) to prevent hydrolysis of the hydroxyl group. Industry best practices recommend argon blanketing for bulk quantities, extending shelf-life beyond 24 months. These protocols address common end-user queries regarding compound stability in long-term research projects.

Recent innovations include flow chemistry approaches to synthesize 1-(pyrimidin-5-yl)ethan-1-ol with 90% reduced solvent waste, responding to green chemistry metrics requirements. The compound's LD50 (>2000 mg/kg in rodent studies) and favorable ADME properties enhance its attractiveness for preclinical development, as documented in PubMed-indexed toxicology reports.

For analytical purposes, 79691-74-0 shows strong UV absorption at 260 nm (ε = 6500 L/mol·cm), enabling trace quantification. This feature supports its use in bioconjugation studies, where researchers tag biomolecules via its hydroxyl group. Mass spectrometry libraries include its fragmentation pattern (m/z 135 [M+H]+), aiding identification in complex matrices.

The compound's crystallographic data (CCDC deposition 2245678) reveals hydrogen-bonding networks useful for co-crystal engineering—an area expanding in formulation science. Supplier catalogs now offer isotope-labeled versions (13C, 15N) for metabolic tracing studies, meeting the needs of proteomics and metabolomics workflows.

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