Production Method 1

69142-64-9

79651-64-2

Reaction Conditions

1.1 Reagents: Calcium chloride ,  Sodium borohydride Solvents: Ethanol ;  cooled; 2 h, 0 °C
1.2 Reagents: Water ;  0 °C

Reference

Metallo-Controlled Dynamic Molecular Tweezers: Design, Synthesis, and Self-Assembly by Metal-Ion Coordination

Ulrich, Sebastien; et al, European Journal of Inorganic Chemistry, 2010, (13), 1913-1928

Production Method 2

79651-64-2

Reaction Conditions

1.1 Reagents: Sodium hydroxide Solvents: Ethanol ,  Water ;  6 h, reflux

Reference

Specificity in crystal engineering: polymerization and dimerization motif design in pyridine system

Goswami, Shyamaprosad; et al, Letters in Organic Chemistry, 2007, 4(6), 448-451

Production Method 3

79651-64-2

Reaction Conditions

1.1 Reagents: Sodium acetate ,  Sodium iodide Solvents: Ethanol
1.2 Reagents: Hydrazine
1.3 Solvents: Water
1.4 Solvents: Chloroform

Reference

N-Bromosuccinimide reactions of some heterocycles in the presence or absence of water: an overview of ring versus side chain bromination for the synthesis of important brominated heterocyclic synthons

Goswami, Shyamaprosad; et al, Journal of Heterocyclic Chemistry, 2001, 38(1), 173-178

Production Method 4

1824-81-3

79651-64-2

Reaction Conditions

1.1 Reagents: Permanganic acid (HMnO4), potassium salt (1:1) Solvents: Ethanol
2.1 Reagents: Lithium aluminum hydride

Reference

Basic carbapenem analogs: synthesis and in vitro activity of 1β-methyl-2-(pyridylmethylthio)-carbapenems

Balkovec, James M.; et al, Journal of Antibiotics, 1991, 44(10), 1172-7

Production Method 5

5327-33-3

79651-64-2

Reaction Conditions

1.1 Reagents: Permanganic acid (HMnO4), potassium salt (1:1) Solvents: Water ;  75 °C
1.2 Reagents: Sulfuric acid Solvents: Ethanol ;  reflux
2.1 Reagents: Calcium chloride ,  Sodium borohydride Solvents: Ethanol ;  cooled; 2 h, 0 °C
2.2 Reagents: Water ;  0 °C

Reference

Metallo-Controlled Dynamic Molecular Tweezers: Design, Synthesis, and Self-Assembly by Metal-Ion Coordination

Ulrich, Sebastien; et al, European Journal of Inorganic Chemistry, 2010, (13), 1913-1928

Production Method 6

69142-64-9

79651-64-2

Reaction Conditions

1.1 Reagents: Lithium aluminum hydride

Reference

Basic carbapenem analogs: synthesis and in vitro activity of 1β-methyl-2-(pyridylmethylthio)-carbapenems

Balkovec, James M.; et al, Journal of Antibiotics, 1991, 44(10), 1172-7

Production Method 7

79651-64-2

Reaction Conditions

1.1 Reagents: Hydrochloric acid Solvents: Water ;  overnight, 80 °C; cooled
1.2 Reagents: Sodium hydroxide Solvents: Water ;  neutralized, rt

Reference

Synthesis of 2-Pyridinemethyl Ester Derivatives from Aldehydes and 2-Alkylheterocycle N-Oxides via Copper-Catalyzed Tandem Oxidative Coupling-Rearrangement

Wang, Chang-Sheng; et al, Organic Letters, 2017, 19(24), 6720-6723

Production Method 8

100-52-7

79651-64-2

Reaction Conditions

1.1 Reagents: tert-Butyl peroxide Catalysts: 1,10-Phenanthroline ,  Bromo[1,1′-thiobis[methane]]copper Solvents: tert-Butanol ,  1,2-Dichloroethane ;  16 h, 120 °C
2.1 Reagents: Hydrochloric acid Solvents: Water ;  overnight, 80 °C; cooled
2.2 Reagents: Sodium hydroxide Solvents: Water ;  neutralized, rt

Reference

Synthesis of 2-Pyridinemethyl Ester Derivatives from Aldehydes and 2-Alkylheterocycle N-Oxides via Copper-Catalyzed Tandem Oxidative Coupling-Rearrangement

Wang, Chang-Sheng; et al, Organic Letters, 2017, 19(24), 6720-6723

Production Method 9

1824-81-3

79651-64-2

Reaction Conditions

1.1 -
2.1 Reagents: Permanganic acid (HMnO4), potassium salt (1:1) Solvents: Water ;  75 °C
2.2 Reagents: Sulfuric acid Solvents: Ethanol ;  reflux
3.1 Reagents: Calcium chloride ,  Sodium borohydride Solvents: Ethanol ;  cooled; 2 h, 0 °C
3.2 Reagents: Water ;  0 °C

Reference

Metallo-Controlled Dynamic Molecular Tweezers: Design, Synthesis, and Self-Assembly by Metal-Ion Coordination

Ulrich, Sebastien; et al, European Journal of Inorganic Chemistry, 2010, (13), 1913-1928

Production Method 10

127-09-3

111477-43-1

79651-64-2

Reaction Conditions

1.1 Solvents: Acetonitrile ;  8 h, reflux
2.1 Reagents: Sodium hydroxide Solvents: Ethanol ,  Water ;  6 h, reflux

Reference

Specificity in crystal engineering: polymerization and dimerization motif design in pyridine system

Goswami, Shyamaprosad; et al, Letters in Organic Chemistry, 2007, 4(6), 448-451

(6-Aminopyridin-2-yl)methanol Raw materials

• Sodium acetate
• 2-Acetamido-6-methylpyridine
• Propanamide, N-[6-(bromomethyl)-2-pyridinyl]-2,2-dimethyl-
• ethyl 6-aminopyridine-2-carboxylate
• 6-methylpyridin-2-amine
• Benzaldehyde

(6-Aminopyridin-2-yl)methanol Preparation Products

• (6-Aminopyridin-2-yl)methanol (79651-64-2)

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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Aminopyridines and derivatives
• Solvents and Organic Chemicals Organic Compounds Heterocyclic Compounds
• Solvents and Organic Chemicals Organic Compounds Alcohol/Ether

• 628703-69-5(2-Pyridinamine,6-[(aminooxy)methyl]-(9CI))
• 105243-77-4(2-Pyridinemethanol,6-(methylamino)-)
• 303732-34-5(2-Pyridinamine,6-methyl-,conjugatemonoacid,hydrate(2:1)(9CI))
• 153959-27-4(2-Pyridinamine,6-(methoxymethyl)-)
• 23628-31-1(6-Aminopyridine-2-carboxylic acid)
• 1824-81-3(6-methylpyridin-2-amine)
• 898257-89-1(1,8-Naphthyridine-2-methanol, 7-amino-)
• 146859-53-2(1-(6-Aminopyridin-2-yl)ethanol)
• 42051-71-8(2-Pyridinamine,6-methyl-,conjugatemonoacid(9CI))
• 497829-93-3(2-Pyridinemethanol,6-amino-4-methyl-(9CI))