Production Method 1

2067-33-6

79583-98-5

Reaction Conditions

1.1 Reagents: Sodium azide Solvents: Dimethylformamide ;  30 h, 77 °C

Reference

Selectively Targeting Prostate Cancer with Antiandrogen Equipped Histone Deacetylase Inhibitors

Gryder, Berkley E.; Akbashev, Michelle J.; Rood, Michael K.; Raftery, Eric D.; Meyers, Warren M.; et al, ACS Chemical Biology, 2013, 8(11), 2550-2560

Production Method 2

89896-39-9

79583-98-5

Reaction Conditions

1.1 Reagents: Sodium hydroxide Solvents: Methanol ,  Water ;  4 h, rt
1.2 Reagents: Hydrochloric acid Solvents: Water ;  acidified

Reference

Ligand-Directed Selective Protein Modification Based on Local Single-Electron Transfer Catalysis

Sato, Shinichi; Nakamura, Hiroyuki, Angewandte Chemie, 2013, 52(33), 8681-8684

Production Method 3

89896-39-9

79583-98-5

Reaction Conditions

1.1 Reagents: Lithium hydroxide Solvents: Methanol ,  Water ;  cooled; 19 h, rt
1.2 Reagents: Hydrochloric acid Solvents: Water ;  pH 1, rt

Reference

Chemical Targeting of Voltage Sensitive Dyes to Specific Cells and Molecules in the Brain

Fiala, Tomas; Wang, Jihang; Dunn, Matthew; Sebej, Peter; Choi, Se Joon; et al, Journal of the American Chemical Society, 2020, 142(20), 9285-9301

Production Method 4

89896-39-9

79583-98-5

Reaction Conditions

1.1 Reagents: Sodium hydroxide Solvents: Methanol ,  Water ;  4 h, rt
1.2 Reagents: Hydrochloric acid Solvents: Water ;  acidified

Reference

Chemical Synthesis of Cell-Permeable Apoptotic Peptides from in Vivo Produced Proteins

Fricke, Thomas; Mart, Robert J.; Watkins, Catherine L.; Wiltshire, Marie; Errington, Rachel J.; et al, Bioconjugate Chemistry, 2011, 22(9), 1763-1767

Production Method 5

127811-93-2

79583-98-5

Reaction Conditions

1.1 Reagents: Lithium hydroxide Solvents: Tetrahydrofuran ,  Water ;  4 h, rt

Reference

Self-assembling macromolecular chimeras: controlling fibrillization of a β-sheet forming peptide by polymer conjugation

Kakwere, Hamilton; Payne, Richard J.; Jolliffe, Katrina A.; Perrier, Sebastien, Soft Matter, 2011, 7(8), 3754-3757

Production Method 6

89896-39-9

79583-98-5

Reaction Conditions

1.1 Reagents: Sodium hydroxide Solvents: Methanol ,  Water
1.2 Reagents: Hydrochloric acid Solvents: Water

Reference

Synthesis and reactivity of methyl γ-azidobutyrates and ethyl δ-azidovalerates and of the corresponding acid chlorides as useful reagents for the aminoalkylation

Khoukhi, N.; Vaultier, M.; Carrie, R., Tetrahedron, 1987, 43(8), 1811-22

Production Method 7

14660-52-7

79583-98-5

Reaction Conditions

1.1 Reagents: Sodium azide Solvents: Acetone ,  Water ;  overnight, reflux
1.2 Reagents: Potassium hydroxide Solvents: Methanol ,  Water ;  0 °C; overnight, rt
1.3 Reagents: Hydrochloric acid Solvents: Water ;  pH 1

Reference

Efficient Construction of Proline-Containing β-Turn Mimetic Cyclic Tetrapeptides via CuAAC Macrocyclization

Chouhan, Gagan; James, Keith, Organic Letters, 2013, 15(6), 1206-1209

Production Method 8

5454-83-1

79583-98-5

Reaction Conditions

1.1 Reagents: Sodium azide Solvents: Acetone ,  Water ;  overnight, reflux
1.2 Reagents: Potassium hydroxide ;  0 °C; overnight, rt
1.3 Reagents: Hydrochloric acid Solvents: Water ;  pH 1

Reference

An enantioselective strategy for the synthesis of (S)-Tylophorine via one-pot intramolecular Schmidt/Bischler-Napieralski/Imine-reduction cascade sequence

Su, Bo; Chen, Fazhong; Wang, Qingmin, Journal of Organic Chemistry, 2013, 78(6), 2775-2779

Production Method 9

2067-33-6

79583-98-5

Reaction Conditions

1.1 Reagents: Sodium azide Solvents: Dimethyl sulfoxide ;  overnight, rt
1.2 Reagents: Hydrochloric acid Solvents: Water ;  rt

Reference

Modulation of the passive permeability of semipeptidic macrocycles: N- and C-methylations fine-tune conformation and properties

Comeau, Christian; Ries, Benjamin ; Stadelmann, Thomas ; Tremblay, Jacob; Poulet, Sylvain; et al, Journal of Medicinal Chemistry, 2021, 64(9), 5365-5383

Production Method 10

862828-06-6

79583-98-5

Reaction Conditions

1.1 Reagents: Dimethyl sulfoxide ,  Sodium azide Solvents: Dimethyl sulfoxide ;  rt

Reference

Synthesis of Cα methylated carboxylic acids: isosteres of arginine and lysine for use as N-terminal capping residues in polypeptides

Orwig, Kevin S.; Dix, Thomas A., Tetrahedron Letters, 2005, 46(41), 7007-7009

Production Method 11

89896-39-9

79583-98-5

Reaction Conditions

1.1 Reagents: Lithium hydroxide Solvents: Methanol ,  Water ;  0 °C; 16 h, rt

Reference

β-Sultams exhibit discrete binding preferences for diverse bacterial enzymes with nucleophilic residues

Kolb, Roman; Bach, Nina C.; Sieber, Stephan A., Chemical Communications (Cambridge, 2014, 50(4), 427-429

Production Method 12

2067-33-6

79583-98-5

Reaction Conditions

1.1 Reagents: Sodium azide Solvents: Dimethylformamide

Reference

Ps-Al(OTf)3 promoted efficient and novel synthesis of substituted N-aryl lactams

Chaturvedi, Amit K.; Chaturvedi, Devdutt, Chemistry & Biology Interface, 2017, 7(4), 230-235

Production Method 13

2067-33-6

79583-98-5

Reaction Conditions

1.1 Reagents: Sodium azide Solvents: Dimethylformamide

Reference

An efficient and novel approach for the synthesis of substituted N-aryl lactams

Chaturvedi, Devdutt; Chaturvedi, Amit K.; Mishra, Nisha; Mishra, Virendra, Organic & Biomolecular Chemistry, 2012, 10(46), 9148-9151

Production Method 14

89896-39-9

79583-98-5

Reaction Conditions

1.1 Reagents: Lithium hydroxide Solvents: Tetrahydrofuran ,  Water ;  24 h, 80 °C; 80 °C → rt
1.2 Reagents: Hydrochloric acid Solvents: Water ;  < pH 3, rt

Reference

Schmidt Reaction of ω-Azido Valeryl Chlorides Followed by Intermolecular Trapping of the Rearrangement Ions: Synthesis of Assoanine and Related Pyrrolophenanthridine Alkaloids

Ding, Shao-Lei; Ji, Yang; Su, Yan; Li, Rui; Gu, Peiming, Journal of Organic Chemistry, 2019, 84(4), 2012-2021

Production Method 15

14660-52-7

79583-98-5

Reaction Conditions

1.1 Reagents: Sodium azide Solvents: Dimethylformamide ;  4 h, 65 °C; 65 °C → rt
1.2 Reagents: Sodium hydroxide Solvents: Methanol ;  2 h, rt

Reference

Synthesis and biological evaluation of salinomycin triazole analogues as anticancer agents

Huang, Minjian; Deng, Zixin; Tian, Jian; Liu, Tiangang, European Journal of Medicinal Chemistry, 2017, 127, 900-908

Production Method 16

89896-39-9

79583-98-5

Reaction Conditions

1.1 Reagents: Potassium hydroxide Solvents: Methanol ,  Water ;  0 °C; overnight, rt
1.2 Reagents: Hydrochloric acid Solvents: Water ;  pH 1, rt

Reference

Linear-Dendritic Alternating Copolymers

Sun, Haotian ; Haque, Farihah M. ; Zhang, Yi; Commisso, Alex; Mohamed, Mohamed Alaa; et al, Angewandte Chemie, 2019, 58(31), 10572-10576

Production Method 17

14660-52-7

79583-98-5

Reaction Conditions

1.1 Reagents: Sodium azide Solvents: Acetone ,  Water ;  overnight, reflux
1.2 Reagents: Potassium hydroxide Solvents: Methanol ,  Water ;  0 °C; overnight, rt
1.3 Reagents: Hydrochloric acid Solvents: Water ;  pH 1

Reference

CuAAC Macrocyclization: High Intramolecular Selectivity through the Use of Copper-Tris(triazole) Ligand Complexes

Chouhan, Gagan; James, Keith, Organic Letters, 2011, 13(10), 2754-2757

5-Azidopentanoic Acid Raw materials

• 5-Bromovaleric acid
• 2-Oxazolidinone,3-[(2S)-5-bromo-2-methyl-1-oxopentyl]-4-(phenylmethyl)-, (4S)-
• methyl 5-bromopentanoate
• 5-Azidopentanoic acid ethyl ester
• methyl 5-azidopentanoate
• 5-Bromopentanoic Acid Ethyl Ester

5-Azidopentanoic Acid Preparation Products

• 5-Azidopentanoic Acid (79583-98-5)

• 1. An integrated cathode and solid electrolyte via in situ polymerization with significantly reduced interface resistance?
  Jialiang Yuan,Ran Dong,Yuan Li,Yang Liu,Zhuo Zheng,Yuxia Liu,Yan Sun,Benhe Zhong,Zhenguo Wu,Xiaodong Guo Chem. Commun., 2021,57, 13004-13007
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• 3. An antioxidant self-healing hydrogel for 3D cell cultures?
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• 4. An artificial enzyme cascade amplification strategy for highly sensitive and specific detection of breast cancer-derived exosomes?
  Huiying Xu,Lu Zheng,Yu Zhou,Bang-Ce Ye Analyst, 2021,146, 5542-5549
• 5. An amide probe as a selective Al3+ and Fe3+ sensor inside the HeLa and a549 cell lines: Pictet–Spengler reaction for the rapid detection of tryptophan amino acid?
  Bidyut Kumar Kundu,Rinky Singh,Ritudhwaj Tiwari,Debasis Nayak New J. Chem., 2019,43, 4867-4877

• Solvents and Organic Chemicals Organic Compounds Lipids and lipid-like molecules Fatty Acyls Straight chain fatty acids
• Solvents and Organic Chemicals Organic Compounds Lipids and lipid-like molecules Fatty Acyls Fatty acids and conjugates Straight chain fatty acids

• 499101-12-1(Pentanoic acid, 5-azido-2-methyl-, (2S)-)
• 110544-77-9(6-Azidohexanoic acid Methyl ester)
• 135920-28-4(7-azidoheptanoic acid)
• 80667-36-3(12-azidododecanoic acid)
• 1037510-76-1(7-Azidoheptanoic acid Methyl ester)
• 186788-41-0(Decanoic acid, 10-azido-, methyl ester)
• 79598-53-1(6-Azidohexanoic Acid)
• 54447-68-6(4-Azidobutyric acid)
• 141446-69-7(Octanoic acid, 8-azido-, methyl ester)
• 499101-21-2(Pentanoic acid, 5-azido-4-methyl-)