• 1. Fatty acid positional distribution in colostrum and mature milk of women living in Inner Mongolia, North Jiangsu and Guangxi of China?
  Long Deng,Qian Zou,Biao Liu,Wenhui Ye,Chengfei Zhuo,Li Chen,Ze-Yuan Deng,Ya-Wei Fan,Jing Li Food Funct., 2018,9, 4234-4245
• 2. Excess electrons in lithium–ethylamine solutions—density, electrical conductivity and EPR studies
  Phys. Chem. Chem. Phys., 1999,1, 3561-3565
• 3. Fast synthesis of red Li3BaSrLn3(WO4)8:Eu3+ phosphors for white LEDs under near-UV excitation by a microwave-assisted solid state reaction method and photoluminescence studies
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• 4. Enantio- & chemo-selective preparation of enantiomerically enriched aliphatic nitro alcohols using Candida parapsilosis ATCC 7330
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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Azoles Pyrazoles

Comprehensive Overview of 1-Methyl-1H-pyrazole-4-carbonyl chloride (CAS No. 79583-19-0): Properties, Applications, and Industry Trends

The 1-methyl-1H-pyrazole-4-carbonyl chloride (CAS 79583-19-0) is a specialized organic compound widely recognized for its role as a versatile building block in pharmaceutical and agrochemical synthesis. With the molecular formula C₅H₅ClN₂O, this pyrazole derivative features a reactive carbonyl chloride group, enabling efficient acylation reactions. Its unique structure has garnered significant attention in research circles, particularly for designing heterocyclic compounds and small-molecule inhibitors targeting enzyme pathways.

Recent trends in drug discovery highlight the growing demand for 1-methyl-1H-pyrazole-4-carbonyl chloride as a precursor for kinase inhibitors and anti-inflammatory agents. Industry reports indicate a 15% annual increase in its utilization for developing JAK/STAT pathway modulators, aligning with the surge in autoimmune disease research. The compound’s compatibility with parallel synthesis techniques also makes it valuable for high-throughput screening libraries, addressing the pharmaceutical sector’s need for rapid lead optimization.

From a synthetic chemistry perspective, the CAS 79583-19-0 compound exhibits remarkable stability under inert atmospheres, though it requires strict moisture control due to its hydrolytic sensitivity. Advanced purification methods like recrystallization from anhydrous solvents or column chromatography are recommended to achieve >98% purity, as confirmed by HPLC-UV analysis. These protocols are frequently discussed in forums focusing on organochloride handling best practices.

Environmental and regulatory considerations have shaped recent applications of 1-methyl-1H-pyrazole-4-carbonyl chloride. The compound’s low bioaccumulation potential (logP ~1.2) and rapid degradation under alkaline conditions make it preferable over persistent halogenated reagents in green chemistry initiatives. This aligns with the pharmaceutical industry’s shift toward EPA’s Safer Choice Principles, as evidenced by its inclusion in several sustainable synthetic routes for FDA-approved APIs.

Emerging applications in material science have expanded the utility of 79583-19-0, particularly in synthesizing photoactive polymers and coordination complexes. Researchers at leading institutes have demonstrated its efficacy in creating metal-organic frameworks (MOFs) with tailored pore geometries, addressing search engine queries about “pyrazole-based porous materials”. These developments correlate with the global MOF market’s projected 12.7% CAGR through 2030.

Analytical characterization of 1-methyl-1H-pyrazole-4-carbonyl chloride typically involves FT-IR spectroscopy (characteristic C=O stretch at 1740 cm^-1), NMR (¹H δ 8.25 for pyrazole-H), and mass spectrometry (M⁺ peak at 144 m/z). These data points frequently appear in academic discussions comparing 4-position reactivity across pyrazole carbonyl derivatives, a topic generating substantial organic chemistry community engagement.

Supply chain dynamics reveal that CAS 79583-19-0 maintains stable availability through specialized fine chemical distributors, with technical specifications often including ≥95% purity and argon-packed shipments. Current market analyses suggest regional price variations of 8-12%, influenced by factors like solvent recovery rates and cGMP compliance costs—key considerations for procurement teams searching “bulk pyrazole chloride suppliers”.

Future research directions for 1-methyl-1H-pyrazole-4-carbonyl chloride may explore its potential in bioconjugation chemistry, particularly for proteolysis-targeting chimeras (PROTACs)—a trending topic in targeted protein degradation therapies. Preliminary studies indicate its acylating capability could enable novel E3 ligase binder attachments, positioning it as a candidate for next-generation cancer therapeutics development.

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