Production Method 1

77326-36-4

79544-29-9

Reaction Conditions

1.1 Reagents: Hydrochloric acid Solvents: Water ;  rt → 0 °C
1.2 Reagents: Sodium nitrite Solvents: Water ;  0 °C; 0.5 h, 0 °C
1.3 Reagents: Potassium iodide Solvents: Water ;  -5 - 0 °C; 15 h, rt

Reference

Synthesis of antineoplastic agent linifanib

Liu, Hailong; Zhu, Wufu; Guo, Qiuting; Wang, Jianqiang; Wang, Xiao; et al, Zhongguo Yaowu Huaxue Zazhi, 2012, 22(1), 26-28

Production Method 2

394-47-8

79544-29-9

Reaction Conditions

1.1 Reagents: N-Iodosuccinimide Catalysts: p-Toluenesulfonic acid ,  Palladium diacetate Solvents: 1,2-Dichloroethane ;  12 h, 70 °C

Reference

Super-Electron-Donor 2-Azaallyl Anions Enable Construction of Isoquinolines

Zi, Quanxing; Li, Minyan ; Cong, Jielun; Deng, Guogang; Duan, Shengzu; et al, Organic Letters, 2022, 24(9), 1786-1790

Production Method 3

77326-36-4

79544-29-9

Reaction Conditions

1.1 Reagents: Sodium nitrite ,  Hydrochloric acid Solvents: Water
1.2 Reagents: Potassium iodide Solvents: Water

Reference

Direct synthesis of 2,4-diaminoquinazolines from 2-fluorobenzonitriles

Hynes, John B.; Pathak, Alpana; Panos, Constantina H.; Okeke, Claudia C., Journal of Heterocyclic Chemistry, 1988, 25(4), 1173-7

Production Method 4

77326-36-4

79544-29-9

Reaction Conditions

1.1 Reagents: Sodium nitrite ,  Hydrochloric acid Solvents: Water ;  1 h, 0 °C
1.2 Reagents: Potassium iodide Solvents: Water ;  12 h, rt

Reference

Nitrile stabilized synthesis of pyrrolidine and piperidine derivatives via tandem alkynyl aza-Prins-Ritter reactions

Shit, Sudip; Choudhury, Chinmayee; Saikia, Anil K., Organic & Biomolecular Chemistry, 2024, 22(3), 568-578

Production Method 5

77326-36-4

79544-29-9

Reaction Conditions

1.1 Reagents: Sodium nitrite ,  Hydrochloric acid Solvents: Water ;  30 min, 0 °C → 5 °C
1.2 Reagents: Potassium iodide Solvents: Water ;  4 h, 5 °C → rt

Reference

Super acid catalyzed sequential hydrolysis/cycloisomerization of o-(acetylenic)benzamides under microwave condition: Synthesis, antinociceptive and antiinflammatory activity of substituted isocoumarins

Praveen, Chandrasekaran; Dheenkumar, P.; Perumal, P. T., Journal of Chemical Sciences (Bangalore, 2013, 125(1), 71-83

2-Fluoro-6-iodobenzonitrile Raw materials

• 2-amino-6-fluoro-benzonitrile
• 2-Fluorobenzonitrile

2-Fluoro-6-iodobenzonitrile Preparation Products

• 2-Fluoro-6-iodobenzonitrile (79544-29-9)

• 1. An atmosphere and light tuned highly diastereoselective synthesis of cyclobuta/penta[b]indoles from aniline-tethered alkylidenecyclopropanes with alkynes?
  Bo Cao,Yin Wei Chem. Commun., 2018,54, 2870-2873
• 2. Achieving crystal-induced room temperature phosphorescence and reversible photochromic properties by strong intermolecular interactions?
  Fuming Xiao,Mengzhu Wang,Yunxiang Lei,Wenbo Dai,Yunbing Zhou,Miaochang Liu,Wenxia Gao,Xiaobo Huang,Huayue Wu J. Mater. Chem. C, 2020,8, 17410-17416
• 3. An ionic liquid-based synergistic extraction strategy for rare earths?
  Yingbo Li,Nada Mehio,Huizhou Liu,Sheng Dai Green Chem., 2015,17, 2981-2993
• 4. An atomistic mechanism for the degradation of perovskite solar cells by trapped charge?
  Eunhak Lim,Jiyoung Heo,Seong Keun Kim Nanoscale, 2019,11, 11369-11378
• 5. An amorphous carbon nitride/NiO/CoN-based composite: a highly efficient nonprecious electrode for supercapacitors and the oxygen evolution reaction?
  Huifang Yang,Haoran Guo,Peidong Fan,Xinpan Li,Wenlu Ren,Rui Song Nanoscale, 2020,12, 7024-7034

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzonitriles

• 443-85-6(2-Fluoro-6-iodotoluene)
• 1000577-68-3(3-Chloro-2-fluoro-6-iodobenzonitrile)
• 217816-66-5(3-bromo-2-fluoro-6-iodobenzonitrile)
• 1031929-20-0(4-Fluoro-2-iodobenzonitrile)
• 877868-92-3(5-fluoro-2-iodobenzonitrile)
• 909185-86-0(2-Fluoro-3-iodo-4-methylbenzonitrile)
• 137553-42-5(2-Fluoro-4-iodobenzonitrile)
• 351003-36-6(2-Fluoro-5-iodobenzonitrile)
• 819057-04-0(BENZONITRILE, 2-FLUORO-3-(HYDROXYMETHYL)-6-IODO-)
• 796968-89-3(4-bromo-2-fluoro-6-iodobenzonitrile)