Cas no 79397-50-5 (Methyl pyrrolidine-2-carboxylate hydrochloride)

Methyl pyrrolidine-2-carboxylate hydrochloride is a chiral building block widely used in organic synthesis and pharmaceutical applications. This compound serves as a versatile intermediate for the preparation of pyrrolidine-based scaffolds, which are prevalent in bioactive molecules and drug candidates. The hydrochloride salt form enhances stability and solubility, facilitating handling and storage. Its ester functionality allows for further derivatization, while the pyrrolidine ring contributes to conformational rigidity, making it valuable in medicinal chemistry. The product is characterized by high purity and consistent quality, ensuring reliable performance in synthetic routes. It is particularly useful in asymmetric synthesis and the development of peptidomimetics or small-molecule therapeutics.
Methyl pyrrolidine-2-carboxylate hydrochloride structure
79397-50-5 structure
Product Name:Methyl pyrrolidine-2-carboxylate hydrochloride
CAS No:79397-50-5
MF:C6H12ClNO2
MW:165.617980957031
MDL:MFCD00066138
CID:554918
PubChem ID:12223519
Update Time:2025-10-30

Methyl pyrrolidine-2-carboxylate hydrochloride Chemical and Physical Properties

Names and Identifiers

    • Methyl pyrrolidine-2-carboxylate hydrochloride
    • H-DL-Pro-OMe.HCl
    • C6H12ClNO2
    • DL-Proline methyl ester hydrochloride
    • DL-PRO-OME-OH (DL-PROLINE METHYL ESTER)
    • H-DL-PRO-OME HCL
    • H-DL-Pro-OMe·HCl
    • Proline, methyl ester,hydrochloride (1:1)
    • (S)-proline methylester hydrochloride
    • L-PROLINE METHYL ESTER
    • L-proline methylester hydrochloride
    • Methyl L-prolinate hydrochloride
    • Methyl pyrrolidine-2-carboxylate HCl
    • methyl pyrrolidine-2-carboxylate monohydrochloride
    • proline hydrochloride methylester
    • proline methyl ester HCl
    • proline methyl ester hydrochloride
    • FT-0625607
    • Calcium phospharyl choline chloride
    • 79397-50-5
    • FT-0641716
    • Proline, methyl ester, hydrochloride (1:1)
    • SY005778
    • pyrrolidine-2-carboxylic acid methyl ester hydrochloride salt
    • HQEIPVHJHZTMDP-UHFFFAOYSA-N
    • SY033211
    • Methylpyrrolidine-2-carboxylate hydrochloride
    • H-DL-Pro-OMe . HCl
    • DS-16212
    • F8889-3632
    • Methyl DL-prolinate hydrochloride
    • DL-Proline, methyl ester, hydrochloride
    • pyrrolidine-2-carboxylic acid methyl ester hydrochloride
    • CS-W004744
    • SCHEMBL190501
    • methyl pyrrolidine-2-carboxylate;hydrochloride
    • A929091
    • SY018101
    • Proline, methyl ester, hydrochloride
    • MFCD00066138
    • FT-0628006
    • Methyl proline hydrochloride, (RS)-
    • A815280
    • H-DL-Pro-OMe hydrochloride, AldrichCPR
    • H-DL-Pro-OMe-HCl
    • UNII-X3PYL8G736
    • Q27293521
    • X3PYL8G736
    • DTXSID10481205
    • EN300-27614
    • A864868
    • 2-pyrrolidinecarboxylic acid methyl ester hydrochloride
    • Methyl prolinate hydrochloride (H-DL-Pro-OMe.HCl)
    • H-D-PRO-OME HCL
    • AKOS005255394
    • DL-Proline, methyl ester, hydrochloride (ZCI)
    • Proline, methyl ester, hydrochloride (9CI)
    • DB-054805
    • DB-056362
    • DB-045553
    • MDL: MFCD00066138
    • Inchi: 1S/C6H11NO2.ClH/c1-9-6(8)5-3-2-4-7-5;/h5,7H,2-4H2,1H3;1H
    • InChI Key: HQEIPVHJHZTMDP-UHFFFAOYSA-N
    • SMILES: Cl.O=C(C1CCCN1)OC

Computed Properties

  • Exact Mass: 165.05600
  • Monoisotopic Mass: 165.0556563g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 2
  • Hydrogen Bond Acceptor Count: 3
  • Heavy Atom Count: 10
  • Rotatable Bond Count: 2
  • Complexity: 114
  • Covalently-Bonded Unit Count: 2
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 1
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Topological Polar Surface Area: 38.3?2

Experimental Properties

  • PSA: 38.33000
  • LogP: 1.04220

Methyl pyrrolidine-2-carboxylate hydrochloride Security Information

  • Hazard Category Code: 36
  • Safety Instruction: 26
  • Storage Condition:-15°C

Methyl pyrrolidine-2-carboxylate hydrochloride Customs Data

  • HS CODE:2933990090
  • Customs Data:

    China Customs Code:

    2933990090

    Overview:

    2933990090. Other heterocyclic compounds containing only nitrogen heteroatoms. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:20.0%

    Declaration elements:

    Product Name, component content, use to, Please indicate the appearance of Urotropine, 6- caprolactam please indicate the appearance, Signing date

    Summary:

    2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Methyl pyrrolidine-2-carboxylate hydrochloride Pricemore >>

Related Categories No. Product Name Cas No. Purity Specification Price update time Inquiry
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Methyl pyrrolidine-2-carboxylate hydrochloride Production Method

Production Method 1

Reaction Conditions
1.1 Reagents: Thionyl chloride
Reference
Stereochemical preference in the reactions of N-protected L-amino acid 1-hydroxybenzotriazole esters with racemic amino acid derivatives
Miyazawa, Toshifumi; Ozawa, Ayako; Furuhashi, Motohiro; Munegumi, Toratane, Protein & Peptide Letters, 2009, 16(3), 297-300

Production Method 2

Reaction Conditions
1.1 Reagents: Thionyl chloride Solvents: Methanol ;  0 °C; 0 °C → rt; 20 h, rt
Reference
Transition metal-free N-arylation of amino acid esters with diaryliodonium salts
Kervefors, Gabriella; Kersting, Leonard; Olofsson, Berit, Chemistry - A European Journal, 2021, 27(18), 5790-5795

Production Method 3

Reaction Conditions
1.1 Reagents: Thionyl chloride Solvents: Methanol
Reference
Generation and [2,3]-Sigmatropic Rearrangement of Ammonium Ylides from Cyclopropyl Ketones for Chiral Indolizidines with Bridgehead Quaternary Stereocenters
Xi, Song; Jiang, Yan; Yang, Jiaojiao; Yang, Jiao; Miao, Dingyin; et al, Organic Letters, 2022, 24(38), 6957-6961

Production Method 4

Reaction Conditions
1.1 Reagents: Thionyl chloride Solvents: Methanol ;  10 min, 0 °C; 5 h, reflux
Reference
Discovery of γ-lactam derivatives containing 1,3-benzodioxole unit as potential anti-phytopathogenic fungus agents
Song, Di; Cao, Xiufang; Wang, Jingjing; Ke, Shaoyong, Bioorganic & Medicinal Chemistry Letters, 2020, 30(2),

Methyl pyrrolidine-2-carboxylate hydrochloride Raw materials

Methyl pyrrolidine-2-carboxylate hydrochloride Preparation Products

Methyl pyrrolidine-2-carboxylate hydrochloride Suppliers

Suzhou Senfeida Chemical Co., Ltd
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(CAS:79397-50-5)H-DL-PRO-OME HCL
Order Number:sfd6959
Stock Status:in Stock
Quantity:200kg
Purity:99.9%
Pricing Information Last Updated:Friday, 19 July 2024 14:34
Price ($):discuss personally
YAN TAI LANG YU XIN CAI LIAO Technology Co., Ltd.
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(CAS:79397-50-5)Methyl pyrrolidine-2-carboxylate hydrochloride
Order Number:LE083
Stock Status:inquiry
Quantity:1KG
Purity:99%
Pricing Information Last Updated:Tuesday, 16 September 2025 16:15
Price ($):inquiry

Additional information on Methyl pyrrolidine-2-carboxylate hydrochloride

Methyl Pyrrolidine-2-Carboxylate Hydrochloride: A Comprehensive Overview

Methyl pyrrolidine-2-carboxylate hydrochloride, with the CAS number 79397-50-5, is a versatile compound that has garnered significant attention in various scientific and industrial applications. This compound, often referred to as methyl pyrrolidine-2-carboxylate hydrochloride, is a derivative of pyrrolidine, a five-membered nitrogen-containing heterocyclic compound. The hydrochloride form of this compound is particularly notable for its stability and reactivity under different chemical conditions.

The structure of methyl pyrrolidine-2-carboxylate hydrochloride consists of a pyrrolidine ring with a carboxylic acid group at the 2-position, which is esterified with a methyl group. The presence of the hydrochloride ion makes this compound highly soluble in water, which is advantageous for its use in aqueous environments. Recent studies have highlighted its potential as a biodegradable polymer precursor, making it a promising candidate for sustainable materials development.

One of the most significant advancements in the study of methyl pyrrolidine-2-carboxylate hydrochloride involves its application in drug delivery systems. Researchers have explored its ability to form self-assembling structures, such as micelles and nanoparticles, which can encapsulate and deliver therapeutic agents with enhanced efficiency. These findings underscore its potential in the pharmaceutical industry, particularly for targeted drug delivery applications.

In addition to its pharmaceutical applications, methyl pyrrolidine-2-carboxylate hydrochloride has also found utility in the field of cosmetic chemistry. Its ability to act as a conditioning agent and humectant makes it a valuable ingredient in personal care products, such as shampoos and conditioners. Recent studies have demonstrated its effectiveness in improving hair texture and reducing damage caused by chemical treatments.

The synthesis of methyl pyrrolidine-2-carboxylate hydrochloride typically involves the reaction of pyrrolidine-2-carboxylic acid with methanol in the presence of an acid catalyst, followed by neutralization with hydrochloric acid. This process ensures the formation of the desired ester and its corresponding hydrochloride salt. The reaction conditions are optimized to maximize yield and purity, ensuring that the final product meets stringent quality standards.

From an environmental perspective, methyl pyrrolidine-2-carboxylate hydrochloride has been shown to exhibit low toxicity and biodegradability under aerobic conditions. These properties make it an eco-friendly alternative to traditional chemicals used in various industries. Ongoing research is focused on further enhancing its biocompatibility and exploring novel applications in fields such as bio-based polymers and sustainable agriculture.

In conclusion, methyl pyrrolidine-2-carboxylate hydrochloride (CAS No: 79397-50-5) is a multifaceted compound with diverse applications across multiple disciplines. Its unique chemical properties, coupled with recent advancements in its synthesis and application, position it as a key player in the development of innovative solutions for modern challenges. As research continues to uncover new potentials for this compound, its role in shaping future technologies will undoubtedly expand further.

Recommended suppliers
Suzhou Senfeida Chemical Co., Ltd
(CAS:79397-50-5)H-DL-PRO-OME HCL
sfd6959
Purity:99.9%
Quantity:200kg
Price ($):Inquiry
Email
YAN TAI LANG YU XIN CAI LIAO Technology Co., Ltd.
(CAS:79397-50-5)Methyl pyrrolidine-2-carboxylate hydrochloride
LE083
Purity:99%
Quantity:1KG
Price ($):Inquiry
Email