Production Method 1

78208-74-9

792969-85-8

Reaction Conditions

1.1 Reagents: Thionyl chloride ;  3 h, reflux
1.2 Reagents: Ammonia Solvents: Acetone ,  Water ;  pH 10

Reference

A facile, improved synthesis of sildenafil and its analogues

Raghava Reddy, Ambati. V.; Srinivas, Garaga; Takshinamoorthy, Chandiran; Gupta Peruri, Badarinadh; Naidu, Andra, Scientia Pharmaceutica, 2016, 84(3), 447-455

Production Method 2

911715-32-7

792969-85-8

Reaction Conditions

1.1 Reagents: Ammonium hydroxide ;  2 h, 60 °C; 3 h, 80 °C; cooled

Reference

Syntheses and vasodilatory activities of new pyrazolo[4,3-d]pyrimidin-7-ones

Zhao, Yan-fang; Zhai, Xin; Chen, Jiao-yue; Guo, Shu-chun; Gong, Ping, Chemical Research in Chinese Universities, 2006, 22(4), 468-473

1H-Pyrazole-5-carboxamide,1-methyl-3-(1-methylethyl)-4-nitro- Raw materials

• 1H-Pyrazole-5-carboxylic acid, 1-methyl-3-(1-methylethyl)-4-nitro-, ethyl ester
• 1-methyl-4-nitro-3-(propan-2-yl)-1H-pyrazole-5-carboxylic acid

1H-Pyrazole-5-carboxamide,1-methyl-3-(1-methylethyl)-4-nitro- Preparation Products

• 1H-Pyrazole-5-carboxamide,1-methyl-3-(1-methylethyl)-4-nitro- (792969-85-8)

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