Production Method 1

100-51-6

5451-40-1

79064-26-9

Reaction Conditions

1.1 Reagents: Triphenylphosphine ,  Silica Solvents: Tetrahydrofuran ;  rt; 6 h, 70 °C; 6 h, 70 °C; 70 °C → rt
1.2 Reagents: Sodium chloride Solvents: Water ;  rt

Reference

Mitsunobu Coupling of Nucleobases and Alcohols: An Efficient, Practical Synthesis for Novel Nonsugar Carbon Nucleosides

Lu, Weibing; Sengupta, Sujata; Petersen, Jeffrey L.; Akhmedov, Novruz G.; Shi, Xiaodong, Journal of Organic Chemistry, 2007, 72(13), 5012-5015

Production Method 2

100-51-6

5451-40-1

79064-26-9

Reaction Conditions

1.1 Reagents: Triphenylphosphine Solvents: Tetrahydrofuran ;  rt → 0 °C
1.2 Reagents: Diisopropyl azodicarboxylate ;  0 - 20 °C; 2 - 4 h, 20 °C

Reference

Trisubstituted purine inhibitors of PDGFRα and their antileukemic activity in the human eosinophilic cell line EOL-1

Malinkova, Veronika; Reznickova, Eva; Jorda, Radek; Gucky, Tomas; Krystof, Vladimir, Bioorganic & Medicinal Chemistry, 2017, 25(24), 6523-6535

Production Method 3

5451-40-1

79064-26-9

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Dimethyl sulfoxide

Reference

9-Benzyl-6-(dimethylamino)-9H-purines with antirhinovirus activity

Kelley, James L.; Linn, James A.; Krochmal, Mark P.; Selway, J. W. T., Journal of Medicinal Chemistry, 1988, 31(10), 2001-4

Production Method 4

5451-40-1

79064-26-9

Reaction Conditions

1.1 Catalysts: Tetrabutylammonium fluoride Solvents: Tetrahydrofuran ;  10 min, rt

Reference

Tetrabutylammonium fluoride-assisted rapid N9-alkylation on purine ring: Application to combinatorial reactions in microtiter plates for the discovery of potent sulfotransferase inhibitors in situ

Brik, Ashraf; Wu, Chung-Yi; Best, Michael D.; Wong, Chi-Huey, Bioorganic & Medicinal Chemistry, 2005, 13(15), 4622-4626

Production Method 5

5451-40-1

79064-26-9

Reaction Conditions

1.1 Reagents: tert-Butyl peroxide Catalysts: Tetrabutylammonium iodide ;  12 h, 90 °C; 90 °C → rt
1.2 Reagents: Sodium bisulfite Solvents: Water ;  rt

Reference

C-H Amination of Purine Derivatives via Radical Oxidative Coupling

Luo, Zheng; Jiang, Ziyang; Jiang, Wei; Lin, Dongen, Journal of Organic Chemistry, 2018, 83(7), 3710-3718

Production Method 6

56046-25-4

79064-26-9

Reaction Conditions

1.1 Reagents: Chlorotrimethylsilane ,  2-Chloro-7-(phenylmethyl)-7H-purin-6-amine Solvents: Dichloromethane ;  1 h, rt; rt; 30 min, rt
1.2 Reagents: Isoamyl nitrite ;  rt; 16 h, rt

Reference

Synthesis, Photophysical Behavior, and Electronic Structure of Push-Pull Purines

Butler, Roslyn S.; Cohn, Pamela; Tenzel, Phillip; Abboud, Khalil A.; Castellano, Ronald K., Journal of the American Chemical Society, 2009, 131(2), 623-633

Production Method 7

5451-40-1

79064-26-9

Reaction Conditions

Reference

Synthesis and bronchodilating activity of 2,9-disubstituted adenine derivatives: BB-1502 (9-cyclohexyl-2-propoxy-9H-adenine) and its analogs

Naito, Takayuki; Nakagawa, Susumu; Okita, Takaaki; Yamashita, Haruhiro; Yamasaki, Tetsuro; et al, Chemical & Pharmaceutical Bulletin, 1982, 30(6), 2011-19

Production Method 8

5451-40-1

79064-26-9

Reaction Conditions

Reference

Visible light-induced direct alkylation of the purine C8-H bond with ethers

Lu, Changtong; Histand, Gary; Lin, Dongen, Organic & Biomolecular Chemistry, 2023, 21(15), 3167-3171

9-Benzyl-2,6-dichloro-9H-purine Raw materials

• 9-Benzyl-2-chloro-9H-purin-6-amine
• Benzyl alcohol
• 2,6-dichloro-9H-purine

9-Benzyl-2,6-dichloro-9H-purine Preparation Products

• 9-Benzyl-2,6-dichloro-9H-purine (79064-26-9)

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