Cas no 79-95-8 (3,5,3',5'-Tetrachlorobisphenol A)

3,5,3',5'-Tetrachlorobisphenol A (TCBPA) is a chlorinated derivative of bisphenol A, characterized by the substitution of chlorine atoms at the 3,5,3',5' positions of the phenolic rings. This structural modification enhances its thermal stability and flame-retardant properties, making it a valuable intermediate in the synthesis of high-performance polymers and flame-retardant materials. TCBPA exhibits improved resistance to degradation compared to its non-halogenated counterpart, contributing to its utility in applications requiring durability under harsh conditions. Its reactivity with epoxies and other resins allows for the production of specialized coatings and adhesives with enhanced chemical and thermal resistance. The compound is primarily used in industrial settings where halogenated additives are required for material performance.
3,5,3',5'-Tetrachlorobisphenol A structure
79-95-8 structure
Product Name:3,5,3',5'-Tetrachlorobisphenol A
CAS No:79-95-8
MF:C15H12Cl4O2
MW:366.0665807724
MDL:MFCD00002178
CID:563433
PubChem ID:87576081
Update Time:2025-06-07

3,5,3',5'-Tetrachlorobisphenol A Chemical and Physical Properties

Names and Identifiers

    • 3,5,3?,5?-Tetrachlorobisphenol A
    • Tetrachlorobisphenol A
    • 2,6-dichloro-4-[2-(3,5-dichloro-4-hydroxyphenyl)propan-2-yl]phenol
    • 4-[(3-Methylphenyl)amino]-3-pyridinesulfonamide
    • 2,2′,6,6′-Tetrachloro-4,4′-isopropylidenediphenol
    • 2,2-Bis(3,5-dichloro-4-hydroxyphenyl)propane
    • 4,4'-Isopropylidenebis(2,6-dichlorophenol)
    • Tetrachlorodian
    • Tetrachlordian
    • 2,2',6,6'-TETRACHLOROBISPHENOL A
    • 3,3',5,5'-Tetrachlorobisphenol A
    • 3,5,3',5'-Tetrachlorobisphenol A
    • Tetrachlordian [Czech]
    • Tetrachlorodian [Czech]
    • 2,2-Bis(4-hydroxy-3,5-dichlorophenyl)propane
    • 4,4'-propane-2,2-diylbis(2,6-dichlorophenol)
    • 4,4'-(1-Methylethylidene)bis(2,6-dichlorophenol)
    • Phenol, 4,4'-(1-methylethylid
    • 4,4′-(1-Methylethylidene)bis[2,6-dichlorophenol] (ACI)
    • Phenol, 4,4′-isopropylidenebis[2,6-dichloro- (6CI, 8CI)
    • 2,2-Bis[3,5-dichloro-4-oxyphenyl]propane
    • 2,2′,6,6′-Tetrachlorobisphenol A
    • 3,3′,5,5′-Tetrachlorobisphenol A
    • 3,5,3′,5′-Tetrachlorobisphenol A
    • 4,4′-Isopropylidenebis[2,6-dichlorophenol]
    • NSC 18248
    • NSC 67465
    • NCGC00248700-01
    • 4,6-dichlorophenol)
    • Phenol,4'-(1-methylethylidene)bis[dichloro-
    • 2,5-dichlorophenyl)propane
    • DTXCID601770
    • Phenol,4'-isopropylidenebis[dichloro-
    • UNII-FO0P9ET4BN
    • FO0P9ET4BN
    • Phenol, 4,4'-(1-methylethylidene)bis(2,6-dichloro-
    • BP_16
    • Q27116363
    • CHEBI:35004
    • CHEMBL1738928
    • 4,4'-Isopropylidenebis[2,6-dichlorophenol]
    • NSC67465
    • 4,4'- (1-Methylethylidene)bis(2,6-dichlorophenol)
    • Phenol, 4,4'-(1-methylethylidene)bis[2,6-dichloro-
    • 4,6-dichlorophenol]
    • 2,5-dichloro-4-hydroxyphenyl)propane
    • InChI=1/C15H12Cl4O2/c1-15(2,7-3-9(16)13(20)10(17)4-7)8-5-11(18)14(21)12(19)6-8/h3-6,20-21H,1-2H
    • 2,2-bis(3,5-dichloro-4-hydroxy-phenyl)propane
    • Phenol, 4,4'-(2,2-propanediyl) bis[2,6-dichloro]-
    • Phenol,4'-(1-methylethylidene)bis[2,6-dichloro-
    • CAS-79-95-8
    • NSC-67465
    • 4,4'-(propane-2,2-diyl)bis(2,6-dichlorophenol)
    • 4mgb
    • 2,6,6'-Tetrachlorobisphenol A
    • D92294
    • 4,4 inverted exclamation mark -Isopropylidenebis(2,6-dichlorophenol)
    • 2,6-dichloro-4-[1-(3,5-dichloro-4-hydroxy-phenyl)-1-methyl-ethyl]phenol
    • HSDB 2921
    • AKOS015848853
    • 2,2-bis-(3,5-dichloro-4-hydroxyphenyl)-propane
    • MFCD00002178
    • 2,2-Bis(3,5-dichloro-4-oxyphenyl)propane
    • 3-06-00-05462 (Beilstein Handbook Reference)
    • WLN: QR BG FG DX1&1&R DQ BG FG
    • 3,5,5'-Tetrachlorobisphenol A
    • 4,4'-(1-Methylethylidene)bis[2,6-dichlorophenol
    • 2,5-dichloro-4-oxyphenyl]propane
    • Tetrachlorobisphenol A, analytical standard
    • NSC-18248
    • T0062
    • 4,4'-isopropylidene bis(2,6-dichlorophenol)
    • Tetrachloro bisphenol A
    • FT-0674943
    • Tox21_303582
    • NS00006839
    • 79-95-8
    • 2,2',6,6'-TETRACHLOROBISPHENOL A [HSDB]
    • Phenol,4'-isopropylidenebis[2,6-dichloro-
    • NCGC00257461-01
    • NCGC00258111-01
    • 3,3',5'-Tetrachlorobisphenol A
    • CS-0213235
    • Oprea1_746572
    • Phenol, 4,4'-isopropylidenebis(2,6-dichloro-
    • 4,4'-Isopropylidene-2,2',6,6'-tetrachlorodiphenol
    • Phenol, 4,4'-(1-methylethylidene)bis(dichloro-
    • Phenol, 4,4'-isopropylidenebis(dichloro-
    • TETRACHLOROBISPHENOLA
    • Phenol, 4,4'-isopropylidenebis[2,6-dichloro-
    • NSC18248
    • 3osi
    • EINECS 201-237-4
    • 3,5,3',5'-Tetrachloro-4,4'-dihydroxy-diphenyl-dimethl-methane
    • DTXSID3021770
    • AI3-25181
    • BRN 2059573
    • BIDD:ER0632
    • Tox21_200557
    • SCHEMBL19109
    • 2,2',6,6'-Tetrachloro-4,4'-isopropylidenediphenol
    • XDH
    • MDL: MFCD00002178
    • Inchi: 1S/C15H12Cl4O2/c1-15(2,7-3-9(16)13(20)10(17)4-7)8-5-11(18)14(21)12(19)6-8/h3-6,20-21H,1-2H3
    • InChI Key: KYPYTERUKNKOLP-UHFFFAOYSA-N
    • SMILES: ClC1C(O)=C(Cl)C=C(C(C)(C)C2C=C(Cl)C(O)=C(Cl)C=2)C=1

Computed Properties

  • Exact Mass: 363.95900
  • Monoisotopic Mass: 363.959140g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 2
  • Hydrogen Bond Acceptor Count: 2
  • Heavy Atom Count: 21
  • Rotatable Bond Count: 2
  • Complexity: 310
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Topological Polar Surface Area: 40.5
  • Surface Charge: 0
  • Tautomer Count: 3
  • XLogP3: 6.5

Experimental Properties

  • Color/Form: Uncertain.
  • Density: 1.4000 (estimate)
  • Melting Point: 133.0 to 137.0 deg-C
  • PSA: 40.46000
  • LogP: 6.03730
  • Solubility: Uncertain.

3,5,3',5'-Tetrachlorobisphenol A Security Information

  • Prompt:warning
  • Hazard Statement: H316
  • Warning Statement: P332+P313
  • Hazardous Material transportation number:NONH for all modes of transport
  • Hazard Category Code: 36/37/38
  • Safety Instruction: S26; S37/39
  • RTECS:SL6250000
  • Hazardous Material Identification: Xi
  • Risk Phrases:R36/37/38

3,5,3',5'-Tetrachlorobisphenol A Pricemore >>

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3,5,3',5'-Tetrachlorobisphenol A Production Method

Production Method 1

Reaction Conditions
1.1 Reagents: Sodium hypochlorite Solvents: Methanol ,  Water
1.2 Reagents: Sodium thiosulfate
Reference
1H and 13C NMR spectral assignments of halogenated transformation products of pharmaceuticals and related environmental contaminants
Solakyildirim, Kemal; Bulloch, Daryl N.; Larive, Cynthia K., Magnetic Resonance in Chemistry, 2014, 52(6), 310-317

Production Method 2

Reaction Conditions
1.1 Reagents: Hydrochloric acid ,  Hydrogen peroxide
Reference
Tetrahalogenated 4,4'-dihydroxydiphenylalkanes, their synthesis and some of their reactions
Islam, A. M.; et al, Egyptian Journal of Chemistry, 1980, 20(5), 483-90

3,5,3',5'-Tetrachlorobisphenol A Raw materials

3,5,3',5'-Tetrachlorobisphenol A Preparation Products

3,5,3',5'-Tetrachlorobisphenol A Suppliers

Tiancheng Chemical (Jiangsu) Co., Ltd
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(CAS:79-95-8)3,5,3',5'-Tetrachlorobisphenol A
Order Number:LE13124
Stock Status:in Stock
Quantity:25KG,200KG,1000KG
Purity:99%
Pricing Information Last Updated:Friday, 20 June 2025 12:08
Price ($):discuss personally

Additional information on 3,5,3',5'-Tetrachlorobisphenol A

3,5,3',5'-Tetrachlorobisphenol A (CAS No. 79-95-8): An Overview of Its Properties, Applications, and Recent Research

3,5,3',5'-Tetrachlorobisphenol A (TCBPA), with the CAS number 79-95-8, is a chlorinated derivative of bisphenol A (BPA). This compound has gained significant attention in the scientific community due to its unique chemical properties and potential applications in various industries. TCBPA is characterized by its high thermal stability and resistance to chemical degradation, making it a valuable material in the development of advanced polymers and resins.

The molecular structure of 3,5,3',5'-Tetrachlorobisphenol A consists of two phenol rings substituted with four chlorine atoms. This configuration imparts enhanced stability and reactivity compared to its parent compound, BPA. The presence of chlorine atoms also contributes to the compound's increased hydrophobicity, which is beneficial in applications requiring water resistance.

In recent years, the environmental and health implications of bisphenol derivatives have been extensively studied. While BPA has been linked to various adverse health effects, including endocrine disruption, the impact of 3,5,3',5'-Tetrachlorobisphenol A is less well understood. However, ongoing research is providing valuable insights into its behavior and potential risks.

A study published in the Journal of Environmental Science and Health in 2021 investigated the environmental fate and toxicity of TCBPA. The researchers found that TCBPA exhibits lower bioaccumulation potential compared to BPA but still poses some concerns regarding its persistence in aquatic environments. This finding underscores the need for continued monitoring and assessment of TCBPA's environmental impact.

In the field of materials science, 3,5,3',5'-Tetrachlorobisphenol A has shown promise as a monomer for the synthesis of high-performance polymers. Its unique chemical properties make it suitable for applications requiring enhanced mechanical strength and thermal stability. For instance, TCBPA-based epoxy resins have been developed for use in high-temperature electronics and aerospace components.

The pharmaceutical industry has also explored the potential applications of TCBPA. Preliminary studies suggest that derivatives of TCBPA may have antimicrobial properties, which could be useful in developing new disinfectants or coatings for medical devices. However, further research is needed to fully understand the mechanisms and efficacy of these compounds.

Recent advancements in analytical techniques have facilitated a deeper understanding of TCBPA's behavior at the molecular level. Techniques such as nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry (MS) have been employed to characterize TCBPA and its derivatives with high precision. These tools are essential for optimizing synthesis processes and ensuring product quality.

The regulatory landscape surrounding bisphenol derivatives is evolving rapidly. While TCBPA is not currently subject to the same stringent regulations as BPA, ongoing research may lead to changes in regulatory policies. Companies involved in the production or use of TCBPA are advised to stay informed about these developments to ensure compliance with future regulations.

In conclusion, 3,5,3',5'-Tetrachlorobisphenol A (CAS No. 79-95-8) is a versatile compound with a range of potential applications in materials science and pharmaceuticals. Its unique chemical properties make it an attractive candidate for developing advanced materials with enhanced performance characteristics. However, continued research is necessary to fully understand its environmental and health implications and to optimize its use in various industries.

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