Cas no 79-17-4 (Pimagedine hydrochloride)

Pimagedine hydrochloride is a selective inhibitor of diamine oxidase (DAO) and advanced glycation end-product (AGE) formation. It is primarily utilized in biochemical and pharmacological research to study the role of AGEs in diabetic complications and aging processes. The compound effectively mitigates cross-linking of proteins by inhibiting AGE formation, making it valuable for investigating metabolic disorders and oxidative stress pathways. Its hydrochloride salt form ensures improved solubility and stability in aqueous solutions, facilitating experimental applications. Pimagedine hydrochloride is also noted for its potential neuroprotective properties in preclinical studies. Researchers value its specificity and reproducibility in modulating glycation-related pathways.
Pimagedine hydrochloride structure
Pimagedine hydrochloride structure
Product Name:Pimagedine hydrochloride
CAS No:79-17-4
MF:CH6N4
MW:74.08513879776
MDL:MFCD00242587
CID:81689
PubChem ID:2146
Update Time:2025-05-27

Pimagedine hydrochloride Chemical and Physical Properties

Names and Identifiers

    • pimagedine
    • Aminoguanidine
    • AMINOGUANIDINE HCL
    • [14C]-Pimagedine
    • [3H]-Pimagedine
    • 1-Aminoguanidine
    • amidinohydrazine
    • Aminate base
    • Amino(imino)methylhydrazine
    • amino-guanidine
    • Aminoguanidine (ag)
    • Aminoguanidine mordant
    • hydrazinecarboximidamide
    • N-Aminoguanidine
    • NCGC00015082-07
    • BDBM86154
    • YM-585
    • 79-17-4
    • NSC_2146
    • DTXSID5040964
    • HSCI1_000380
    • DB05383
    • GUANIDINE, AMINO-
    • SR-01000075164-1
    • Hydrazinecarboximidamide(9CI)
    • EINECS 201-183-1
    • CHEMBL225304
    • UNII-SCQ4EZQ113
    • Lopac-A-8835
    • PIMAGEDINE [WHO-DD]
    • CHEBI:40618
    • NCGC00015082-06
    • GER-11
    • SCQ4EZQ113
    • MDL-201228
    • NCGC00015082-04
    • Tocris-0787
    • CAS_2146
    • BDBM50207159
    • CCG-204198
    • NCGC00024791-03
    • Q409583
    • Monoaminoguanidine
    • Lopac0_000103
    • NCGC00015082-05
    • NCGC00015082-14
    • NCGC00024791-02
    • SDCCGSBI-0050039.P002
    • Carbamimidic acid, hydrazide; Guanylhydrazine
    • AMINOGUANIDINE [MI]
    • 2-azanylguanidine
    • NCGC00015082-03
    • NCGC00015082-15
    • amino guanidine
    • NCGC00015082-01
    • AKOS009031153
    • 2-aminoguanidine
    • Imino semicarbazide
    • PIMAGEDINE [MART.]
    • GTPL5135
    • SDCCGSBI-0050091.P002
    • 1-amino-guanidine
    • Lopac0_000050
    • W-104265
    • FT-0693034
    • Lopac-A-7009
    • AB00443011_04
    • NCGC00015082-02
    • NS00018672
    • CCRIS 3511
    • NCGC00024791-01
    • Pimagedine [INN]
    • Guanyl hydrazine
    • AGU
    • AMY873
    • Guanidine, amino- (8CI)
    • Carbamimidic acid, hydrazide
    • Guanylhydrazine
    • STL190849
    • PIMAGEDINE (MART.)
    • DTXCID3020964
    • pimagedina
    • BRD-K25114078-003-08-1
    • HY-B1041A
    • Hydrazinecarboximidamide (9CI)
    • pimagedinum
    • CS-0013747
    • BRD-K25114078-003-07-3
    • Pimagedine hydrochloride
    • MDL： MFCD00242587
    • Inchi： 1S/CH6N4/c2-1(3)5-4/h4H2,(H4,2,3,5)
    • InChI Key： HAMNKKUPIHEESI-UHFFFAOYSA-N
    • SMILES： N=C(NN)N

Computed Properties

  • Exact Mass: 74.05920
  • Monoisotopic Mass: 74.059246
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 4
  • Hydrogen Bond Acceptor Count: 4
  • Heavy Atom Count: 5
  • Rotatable Bond Count: 1
  • Complexity: 41.6
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Surface Charge: 0
  • Tautomer Count: 2
  • XLogP3: -1.5
  • Topological Polar Surface Area: 90.4

Experimental Properties

  • Density: 1.72
  • Boiling Point: 261.4°C at 760 mmHg
  • Flash Point: 111.9°C
  • Refractive Index: 1.6660 (estimate)
  • PSA: 87.92000
  • LogP: 0.23440

Pimagedine hydrochloride Security Information

Pimagedine hydrochloride Pricemore >>

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Pimagedine hydrochloride Production Method

Production Method 1

Reaction Conditions
1.1 Reagents: Hydrazine Solvents: Water
Reference
Reduction of nitroguanidine. III. Synthesis of aminoguanidine
Smith, G. B. L.; Anzelmi, Edward, Journal of the American Chemical Society, 1935, 57,

Production Method 2

Reaction Conditions
1.1 Reagents: Ammonia Solvents: Isopropanol ;  12 h, reflux
Reference
Synthesis, antileishmanial activity and in silico studies of aminoguanidine hydrazones (AGH) and thiosemicarbazones (TSC) against Leishmania chagasi amastigotes
de Aquino, Thiago M. ; Franca, Paulo H. B.; Rodrigues, Erica E. E. S.; Nascimento, Igor. J. S. ; Santos, Paulo F. S. Jr.; et al, Medicinal Chemistry (Sharjah, 2022, 18(2), 151-169

Production Method 3

Reaction Conditions
1.1 Reagents: Hydrazine
Reference
Green catalyst Cu(II)-enzyme-mediated eco-friendly synthesis of 2-pyrimidinamines as potential larvicides against Culex quinquefasciatus mosquito and toxicity investigation against non-target aquatic species
Chidambaram, SathishKumar; Mostafa, Ashraf Abdel-Fattah; Abdulrahman Al-Askar, Abdulaziz; Sayed, Shaban R. M.; Radhakrishnan, SurendraKumar; et al, Bioorganic Chemistry, 2021, 109,

Production Method 4

Reaction Conditions
Reference
Hydrogenation of phenylacetylene and isoprene on Raney nickel catalysts in a hexane-water emulsion
Muratova, V. I.; Kabiev, T. K.; Sokol'skii, D. V., Osn. Organ. Sintez i Neftekhimiya, 1987, (23), 5-15

Production Method 5

Reaction Conditions
Reference
Methanol conversion in the presence of ZSM-5 zeolite. Analysis of reaction products. I
Hlozek, P.; Herain, Jiri; Novansky, Jozef; Moravek, Stefan; Hudec, Pavol, Ropa a Uhlie, 1988, 30(2), 110-16

Production Method 6

Reaction Conditions
Reference
Procedure for the preparation of tertiary olefins
, Federal Republic of Germany, , ,

Production Method 7

Reaction Conditions
1.1 Solvents: Ethanol ;  6 h, rt
Reference
Copper-Functionalized Silica-Coated Magnetic Nanoparticles for an Efficient Suzuki Cross-Coupling Reaction
Sonei, Samin; Taghavi, Faezeh; Khojastehnezhad, Amir ; Gholizadeh, Mostafa, ChemistrySelect, 2021, 6(3), 359-368

Production Method 8

Reaction Conditions
1.1 Reagents: Zinc Solvents: Acetic acid
Reference
Synthesis and characterization of complexes of copper(II) with 2-hydroxyl-1-naphthyl aldehyde guanyl hydrazone
Yang, Weimin; Liu, Lijun; Tuo, Shouwan; Liu, Yan, Huaxue Yanjiu Yu Yingyong, 2008, 20(11), 1476-1479

Production Method 9

Reaction Conditions
Reference
Preparation of C4-C5 isoolefins
, USSR, , ,

Production Method 10

Reaction Conditions
Reference
Methanol conversion in the presence of ZSM-5 zeolite. Analysis of reaction products. II
Hlozek, Pavel; Herain, Jiri; Moravek, Stefan; Novansky, Jozef; Hudec, Pavol, Ropa a Uhlie, 1988, 30(3), 185-92

Pimagedine hydrochloride Raw materials

Pimagedine hydrochloride Preparation Products

Pimagedine hydrochloride Related Literature

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