Production Method 1

177760-52-0

1679-18-1

78979-62-1

Reaction Conditions

1.1 Reagents: Potassium carbonate Catalysts: Tetrakis(triphenylphosphine)palladium Solvents: Toluene ,  Water ;  1 h, 90 °C

Reference

Rational Design, Synthesis and Evaluation of Oxazolo[4,5-c]-quinolinone Analogs as Novel Interleukin-33 Inhibitors

Kim, Yujin; Ma, Chao; Park, Seonghu; Shin-, Yujin; Lee, Taeyun; et al, Chemistry - An Asian Journal, 2021, 16(22), 3702-3712

Production Method 2

109-94-4

39735-52-9

78979-62-1

Reaction Conditions

1.1 Reagents: Sodium hydride Catalysts: 18-Crown-6 Solvents: Toluene ;  0 °C; 0 °C → rt; rt → 60 °C; 20 min, 60 °C; 60 °C → rt
1.2 Solvents: Ethanol ;  rt
1.3 Reagents: Triethylamine ,  Triphenylphosphine ,  Iodine Solvents: Dichloromethane ;  5 min, rt
1.4 Solvents: Dichloromethane ;  12 h, rt

Reference

Synthesis of substituted esters of imidazoles, oxazoles, thiazoles, and diethyl pyrazine-2,5-dicarboxylate from a common acyclic precursor employing C-formylation strategy

Khose, Goraksha; Shinde, Shailesh; Panmand, Anil; Kulkarni, Ravibhushan; Munot, Yogesh; et al, Tetrahedron Letters, 2014, 55(16), 2671-2674

Production Method 3

23012-14-8

1198184-09-6

78979-62-1

Reaction Conditions

1.1 Reagents: Cesium carbonate Catalysts: 1,2-Bis(diphenylphosphino)ethane ,  Palladium diacetate Solvents: N-Methyl-2-pyrrolidone ;  15 h, 100 °C

Reference

Palladium-Catalyzed Direct Arylations, Alkenylations, and Benzylations through C-H Bond Cleavages with Sulfamates or Phosphates as Electrophiles

Ackermann, Lutz; Barfuesser, Sebastian; Pospech, Jola, Organic Letters, 2010, 12(4), 724-726

4-Oxazolecarboxylicacid, 2-(4-chlorophenyl)-, ethyl ester Raw materials

• Ethyl formate
• Ethyl 1,3-oxazole-4-carboxylate
• ethyl 2-amino-1,3-oxazole-4-carboxylate
• (4-chlorophenyl)boronic acid
• Ethyl 2-(4-Chlorobenzoyl)AminoAcetate

4-Oxazolecarboxylicacid, 2-(4-chlorophenyl)-, ethyl ester Preparation Products

• 4-Oxazolecarboxylicacid, 2-(4-chlorophenyl)-, ethyl ester (78979-62-1)

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• 61151-97-1(4-Oxazolecarboxylic acid, 2-(4-chlorophenyl)-5-methyl-, ethyl ester)
• 78979-61-0(4-Oxazolecarboxylicacid, 2-(4-methoxyphenyl)-, ethyl ester)
• 885273-19-8(4-Oxazolecarboxylicacid, 2-(3-methylphenyl)-, ethyl ester)
• 885274-58-8(4-Oxazolecarboxylicacid, 2-(2-ethylphenyl)-, ethyl ester)
• 39819-39-1(ethyl 2-phenyl-1,3-oxazole-4-carboxylate)
• 391248-21-8(Ethyl 2-(4-Aminophenyl)-1,3-oxazole--carboxylate)
• 200400-76-6(Ethyl 2-(4'-Hydroxyphenyl)-1,3-oxazole-4-carboxylate)
• 391248-23-0(Ethyl 2-(4-Bromophenyl)-1,3-Oxazole-4-Carboxylate)
• 132089-43-1(Ethyl 2-(3-chlorophenyl)oxazole-4-carboxylate)
• 885273-06-3(Ethyl 2-(3-Bromophenyl)Oxazole-4-Carboxylate)