Production Method 1

81840-57-5

78954-23-1

Reaction Conditions

1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Ethanol

Reference

Synthesis of yakuchinone derivatives and their inhibitory activities on nitric oxide synthesis

Yoon, Joung Wha; Ahn, Hanna; Ryu, Jae-Ha; Kim, Hee-Doo, Yakhak Hoechi, 2001, 45(1), 16-22

Production Method 2

13633-25-5

78954-23-1

Reaction Conditions

1.1 Reagents: Magnesium Catalysts: Iodine Solvents: Tetrahydrofuran ;  40 °C; 1 h, 40 °C; 40 °C → 0 °C
1.2 0 °C; 3 h, 0 °C → rt

Reference

Concise and efficient total synthesis of oxyphyllacinol, yakuchione-A and yakuchione-B

Shi, Xiang; Deng, Yu; Kurtz, Nicole C.; Sun, Yue; Xue, Mingxing; et al, Synthetic Communications, 2022, 52(4), 513-520

Production Method 3

105955-06-4

78954-23-1

Reaction Conditions

1.1 Reagents: Carbon monoxide ,  1,8-Diazabicyclo[5.4.0]undec-7-ene ,  Water ,  Selenium Solvents: Tetrahydrofuran

Reference

Selective reduction of α,β-unsaturated carbonyl compounds with carbon monoxide and water assisted by selenium

Nishiyama, Yutaka; Makino, Yasuhiko; Hamanaka, Sawako; Ogawa, Akiya; Sonoda, Noboru, Bulletin of the Chemical Society of Japan, 1989, 62(5), 1682-4

Production Method 4

81840-57-5

78954-23-1

Reaction Conditions

1.1 Reagents: Water Catalysts: Palladium

Reference

Suppression of inducible nitric oxide synthase expression by yakuchinones and their analogues

Lee, Hwa Jin; Kim, Ji Sun; Yoon, Joung Wha; Kim, Hee-Doo; Ryu, Jae-Ha, Chemical & Pharmaceutical Bulletin, 2006, 54(3), 377-379

Yakuchinone A Raw materials

• 1-Bromo-4-phenylbutane
• (1E)-1-(4-hydroxy-3-methoxyphenyl)-7-phenylhept-1-en-3-one
• 1-Hepten-3-one, 1-(4-hydroxy-3-methoxyphenyl)-7-phenyl-

Yakuchinone A Preparation Products

• Yakuchinone A (78954-23-1)

• 1. Examination of deposit in commercial diluted phosphoric acid
  Analyst, 1880,5, 146-147
• 2. Excellent mechanical performance and enhanced dielectric properties of OBC/SiO2 elastomeric nanocomposites: effect of dispersion of the SiO2 nanoparticles?
  Xing Zhao,Lu Bai,Rui-Ying Bao,Zheng-Ying Liu,Ming-Bo Yang,Wei Yang RSC Adv., 2017,7, 46297-46305
• 3. Evidence of pre-micellar aggregates in aqueous solution of amphiphilic PDMS–PEO block copolymer?
  Domenico Lombardo,Gianmarco Munaò,Pietro Calandra,Luigi Pasqua,Maria Teresa Caccamo Phys. Chem. Chem. Phys., 2019,21, 11983-11991
• 4. Evolving better nanoparticles: Genetic algorithms for optimising cluster geometries
  Dalton Trans., 2003, 4193-4207
• 5. Evolution of hierarchical porous structures in supramolecular guest–host hydrogels?
  Christopher B. Rodell,Christopher B. Highley,Minna H. Chen,Neville N. Dusaj,Chao Wang,Lin Han,Jason A. Burdick Soft Matter, 2016,12, 7839-7847

• Solvents and Organic Chemicals Organic Compounds Phenylpropanoids and polyketides Diarylheptanoids Linear diarylheptanoids

• 6302-60-9(4-(3,4-dimethoxyphenyl)butan-2-one)
• 27113-22-0(Paradol)
• 27113-23-1(3-Dodecanone,1-(4-hydroxy-3-methoxyphenyl)-)
• 501665-75-4(3,5-Heptanedione, 1-(4-hydroxy-3-methoxyphenyl)-)
• 53172-03-5(3-Nonanone,1-(4-hydroxy-3-methoxyphenyl)-)
• 122-48-5(Zingerone)
• 149579-07-7(3,5-Heptanedione,1-(4-hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)-)
• 53172-02-4(3-Octanone,1-(4-hydroxy-3-methoxyphenyl)-)
• 79067-90-6(3,5-Tetradecanedione,1-(4-hydroxy-3-methoxyphenyl)-)
• 36062-04-1(Tetrahydrocurcumin)