• 1. Exchanged ligands on the surface of a giant cluster: [(MoO3)176(H2O)63(CH3OH)17Hn](32 – n)–
  Chem. Commun., 1998, 1501-1502
• 2. Establishment and implications of a characterization method for magnetic nanoparticle using cell tracking velocimetry and magnetic susceptibility modified solutions
  Huading Zhang,Lee R. Moore,Maciej Zborowski,P. Stephen Williams,Shlomo Margel,Jeffrey J. Chalmers Analyst, 2005,130, 514-527
• 3. Examination of deposit in commercial diluted phosphoric acid
  Analyst, 1880,5, 146-147
• 4. Examination of the hydrogen-bonding networks in small water clusters (n = 2–5, 13, 17) using absolutely localized molecular orbital energy decomposition analysis?
  Erika A. Cobar,Paul R. Horn,Robert G. Bergman,Martin Head-Gordon Phys. Chem. Chem. Phys., 2012,14, 15328-15339
• 5. Emerging investigator series: bacteriophages as nano engineering tools for quality monitoring and pathogen detection in water and wastewater
  Fereshteh Bayat Environ. Sci.: Nano, 2021,8, 367-389

• Solvents and Organic Chemicals Organic Compounds Organic acids and derivatives Carboxylic acids and derivatives Carboxylic acid derivatives Carboxylic acid amides

2-Chloro-N-(1-cyanocycloheptyl)-acetamide (CAS No. 78735-01-0): A Comprehensive Overview

2-Chloro-N-(1-cyanocycloheptyl)-acetamide (CAS No. 78735-01-0) is a chemical compound that has garnered significant attention in the fields of organic chemistry and pharmacology due to its unique structural properties and potential applications. This compound is characterized by its chlorinated acetyl group and a cyanocycloheptyl amine moiety, which contribute to its distinct reactivity and biological activity. Recent studies have highlighted its role in drug discovery, particularly in the development of novel therapeutic agents targeting various disease states.

The synthesis of 2-Chloro-N-(1-cyanocycloheptyl)-acetamide involves a multi-step process that typically begins with the preparation of the cyanocycloheptane ring. This is achieved through cycloaddition reactions or other ring-forming techniques, followed by functionalization to introduce the necessary substituents. The introduction of the chloroacetyl group is a critical step, often involving nucleophilic acyl substitution or other acylation methods. The optimization of these steps has been a focus of recent research, with advancements in catalytic systems and reaction conditions significantly improving yield and purity.

One of the most intriguing aspects of 2-Chloro-N-(1-cyanocycloheptyl)-acetamide is its ability to act as a versatile building block in organic synthesis. Its chlorinated acetyl group makes it an excellent substrate for nucleophilic substitutions, enabling the construction of diverse amide derivatives. Moreover, the cyanocycloheptyl moiety provides a rigid and potentially bioactive framework, which can be further modified to enhance pharmacokinetic properties such as solubility and bioavailability.

Recent research has explored the biological activity of 2-Chloro-N-(1-cyanocycloheptyl)-acetamide and its derivatives. Studies have demonstrated that this compound exhibits moderate inhibitory activity against several enzymes implicated in inflammatory diseases, such as cyclooxygenase (COX) and lipoxygenase (LOX). Additionally, it has shown potential as an antagonist for certain G-protein coupled receptors (GPCRs), which are key targets in the treatment of cardiovascular and neurological disorders.

The structural flexibility of 2-Chloro-N-(1-cyanocycloheptyl)-acetamide has also been exploited in the design of prodrugs and drug delivery systems. By modifying the cyanocycloheptyl ring, researchers have been able to create derivatives with enhanced stability and reduced toxicity, making them more suitable for clinical applications. These advancements underscore the importance of this compound as a valuable tool in medicinal chemistry.

In terms of industrial applications, 2-Chloro-N-(1-cyanocycloheptyl)-acetamide is increasingly being used as an intermediate in the synthesis of agrochemicals and specialty chemicals. Its ability to undergo various transformations while retaining its core structure makes it an attractive candidate for large-scale production processes. Furthermore, its compatibility with modern green chemistry practices has positioned it as a sustainable choice for chemical manufacturers.

Looking ahead, the continued exploration of 2-Chloro-N-(1-cyanocycloheptyl)-acetamide is expected to yield further insights into its potential applications. Ongoing research is focused on optimizing its synthesis, expanding its biological profile, and developing novel formulations that leverage its unique properties. As our understanding of this compound deepens, it is likely to play an even more pivotal role in advancing both academic research and industrial innovation.

• 61555-45-1(Acetamide, 2-chloro-N-(1-cyanobutyl)-N-methyl-)
• 4550-68-9(N-(1-cyanocyclohexyl)acetamide)
• 730950-03-5(2-chloro-N-(1-cyano-1,2-dimethylpropyl)acetamide)
• 78734-62-0(2-CHLORO-N-(1-CYANO-1-CYCLOPROPYLETHYL)ACETAMIDE)
• 78734-78-8(2-chloro-N-(1-cyanocyclohexyl)acetamide)
• 78734-79-9(2-CHLORO-N-(1-CYANOCYCLOHEXYL)-N-METHYLACETAMIDE)
• 207557-35-5((2S)-1-(2-chloroacetyl)pyrrolidine-2-carbonitrile)
• 565452-98-4((2R)-1-(Chloroacetyl)-2-pyrrolidinecarbonitrile)
• 274901-37-0(2-Pyrrolidinecarbonitrile, 1-(chloroacetyl)-)
• 78734-65-3(2-chloro-N-(1-cyanocyclopentyl)acetamide)