Cas no 786719-60-6 (2-Amino-2',4'-difluoroacetophenone Hydrochloride)

2-Amino-2',4'-difluoroacetophenone Hydrochloride is a fluorinated aromatic compound with a molecular formula of C8H7F2NO·HCl. This hydrochloride salt is characterized by its high purity and stability, making it suitable for use as an intermediate in pharmaceutical synthesis and organic chemistry research. The presence of both amino and difluoro substituents enhances its reactivity in nucleophilic and electrophilic reactions, particularly in the construction of heterocyclic frameworks. Its crystalline form ensures consistent handling and solubility in polar solvents. The compound is commonly employed in the development of bioactive molecules, including potential drug candidates, due to its versatile functional groups and reliable performance under controlled conditions.
2-Amino-2',4'-difluoroacetophenone Hydrochloride structure
786719-60-6 structure
Product Name:2-Amino-2',4'-difluoroacetophenone Hydrochloride
CAS No:786719-60-6
MF:C8H8ClF2NO
MW:207.605028152466
MDL:MFCD07783701
CID:68831
Update Time:2025-06-08

2-Amino-2',4'-difluoroacetophenone Hydrochloride Chemical and Physical Properties

Names and Identifiers

    • 2-Amino-1-(2,4-difluorophenyl)ethanone hydrochloride
    • 2-Amino-1-(2,4-difluorophenyl)-ethanone hydrochloride
    • 2-Amino-2',4'-difluoroacetophenone, HCl
    • 2-Amino-2',4'-difluoroacetophenone Hydrochloride
    • MDL： MFCD07783701
    • Inchi： 1S/C8H7F2NO.ClH/c9-5-1-2-6(7(10)3-5)8(12)4-11;/h1-3H,4,11H2;1H
    • InChI Key： IVNYKZOEFAMYSL-UHFFFAOYSA-N
    • SMILES： Cl.FC1C=C(C=CC=1C(CN)=O)F

Computed Properties

  • Exact Mass: 207.02600
  • Hydrogen Bond Donor Count: 1
  • Hydrogen Bond Acceptor Count: 2
  • Heavy Atom Count: 13
  • Rotatable Bond Count: 2

Experimental Properties

  • PSA: 43.09000
  • LogP: 2.60850

2-Amino-2',4'-difluoroacetophenone Hydrochloride Security Information

  • Hazardous Material Identification： Xi

2-Amino-2',4'-difluoroacetophenone Hydrochloride Customs Data

  • HS CODE：2922399090
  • Customs Data：

    China Customs Code:

    2922399090

    Overview:

    2922399090 Other amino aldehydes\Amino ketones and their salts(Including aminoquinone and its salts,Except those containing more than one oxygen-containing group). VAT:17.0% Tax refund rate:9.0% Regulatory conditions:nothing MFN tariff:6.5% general tariff:30.0%

    Declaration elements:

    Product Name, component content, use to, The color of ethanolamine and its salt should be reported, The package of ethanolamine and its salt shall be declared

    Summary:

    2922399090 other amino-aldehydes, amino-ketones and amino-quinones, other than those containing more than one kind of oxygen function; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

2-Amino-2',4'-difluoroacetophenone Hydrochloride Pricemore >>

Related Categories No. Product Name Cas No. Purity Specification Price update time Inquiry
SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd.
A186631-1g
2-Amino-2',4'-difluoroacetophenone Hydrochloride
 786719-60-6 97%
1g
 ￥455.90 2023-09-04
SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd.
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2-Amino-2',4'-difluoroacetophenone Hydrochloride
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Alichem
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2-Amino-1-(2,4-difluorophenyl)ethanone hydrochloride
 786719-60-6 95%
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 $345.42 2023-09-01
Alichem
A019117016-10g
2-Amino-1-(2,4-difluorophenyl)ethanone hydrochloride
 786719-60-6 95%
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 $564.30 2023-09-01
SHANG HAI MAI KE LIN SHENG HUA Technology Co., Ltd.
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 786719-60-6 ≥98%
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Apollo Scientific
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 786719-60-6 99%
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Apollo Scientific
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2,4-Difluorophenacylamine hydrochloride
 786719-60-6 99%
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Chemenu
CM373151-1g
2-Amino-1-(2,4-difluorophenyl)ethanone hydrochloride
 786719-60-6 95%+
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Chemenu
CM373151-5g
2-Amino-1-(2,4-difluorophenyl)ethanone hydrochloride
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TRC
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2-Amino-2',4'-difluoroacetophenone Hydrochloride Related Literature

Additional information on 2-Amino-2',4'-difluoroacetophenone Hydrochloride

Recent Advances in the Study of 2-Amino-2',4'-difluoroacetophenone Hydrochloride (CAS: 786719-60-6)

The compound 2-Amino-2',4'-difluoroacetophenone Hydrochloride (CAS: 786719-60-6) has recently garnered significant attention in the field of chemical biology and pharmaceutical research. This brief aims to synthesize the latest findings related to this compound, focusing on its synthesis, biological activity, and potential applications in drug development. The compound, characterized by its unique difluoroacetophenone structure, has shown promise in various therapeutic areas, including oncology and infectious diseases.

Recent studies have highlighted the compound's role as a key intermediate in the synthesis of novel pharmaceutical agents. A 2023 publication in the Journal of Medicinal Chemistry demonstrated its utility in the development of kinase inhibitors, where it served as a critical building block for compounds targeting aberrant signaling pathways in cancer cells. The study reported that derivatives of 2-Amino-2',4'-difluoroacetophenone Hydrochloride exhibited potent inhibitory activity against specific oncogenic kinases, with IC50 values in the nanomolar range.

In addition to its applications in oncology, research has explored the antimicrobial properties of this compound. A team at the University of Cambridge published findings in Antimicrobial Agents and Chemotherapy, showing that structurally modified versions of 2-Amino-2',4'-difluoroacetophenone Hydrochloride displayed broad-spectrum activity against drug-resistant bacterial strains. The mechanism of action appears to involve disruption of bacterial cell wall synthesis, making it a potential candidate for addressing the global challenge of antibiotic resistance.

The synthetic pathways for 2-Amino-2',4'-difluoroacetophenone Hydrochloride have also seen advancements. A recent patent (WO2023056789) describes an improved, high-yield synthesis method that reduces byproduct formation and enhances purity. This development is particularly significant for scaling up production while maintaining the compound's pharmacological integrity, addressing a critical need in industrial pharmaceutical applications.

Looking ahead, the versatility of 2-Amino-2',4'-difluoroacetophenone Hydrochloride continues to inspire innovative research directions. Current investigations are exploring its potential in neurodegenerative disease therapeutics, with preliminary data suggesting neuroprotective effects in in vitro models of Alzheimer's disease. As research progresses, this compound may emerge as a valuable tool in addressing some of the most pressing challenges in modern medicine.

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