• 1. Embedding heteroatoms: an effective approach to create porphyrin-based functional materials
  Norihito Fukui,Keisuke Fujimoto,Hideki Yorimitsu,Atsuhiro Osuka Dalton Trans., 2017,46, 13322-13341
• 2. Dissociation of aryl sulfonyl phthalimide radical anions: relevance to the biological activity of arylsulfonyl amides?
  Abdelaziz Houmam,Emad M. Hamed Chem. Commun., 2012,48, 11328-11330
• 3. Evidence of field induced slow magnetic relaxation in cis-[Co(hfac)2(H2O)2] exhibiting tri-axial anisotropy with a negative axial component?
  Denis V. Korchagin,Elena A. Yureva,Alexander V. Akimov,Eugenii Ya. Misochko,Gennady V. Shilov,Artem D. Talantsev,Roman B. Morgunov,Alexander A. Shakin,Sergey M. Aldoshin,Boris S. Tsukerblat Dalton Trans., 2017,46, 7540-7548
• 4. Emerging investigator series: bacteriophages as nano engineering tools for quality monitoring and pathogen detection in water and wastewater
  Fereshteh Bayat Environ. Sci.: Nano, 2021,8, 367-389
• 5. Excitation dependent bidirectional electron transfer in phthalocyanine-functionalised MoS2 nanosheets?
  Christopher J. Harrison,Kyle J. Berean,Enrico Della Gaspera,Jian Zhen Ou,Richard B. Kaner,Kourosh Kalantar-zadeh,Torben Daeneke Nanoscale, 2016,8, 16276-16283

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Diazines Halopyrimidines
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Diazines Pyrimidines and pyrimidine derivatives Halopyrimidines

Comprehensive Overview of 2-Chloropyrimidine Hydrochloride (CAS No. 77722-80-6): Properties, Applications, and Industry Insights

2-Chloropyrimidine hydrochloride (CAS No. 77722-80-6) is a versatile heterocyclic compound widely used in pharmaceutical synthesis, agrochemical development, and material science. With the molecular formula C₄H₄Cl₂N₂, this white to off-white crystalline powder has gained significant attention due to its role as a key intermediate in drug discovery and fine chemical manufacturing. Its unique pyrimidine core structure allows for diverse functionalization, making it invaluable in modern organic chemistry.

The growing demand for pyrimidine derivatives in biomedical research has positioned 2-Chloropyrimidine HCl as a critical building block. Recent studies highlight its applications in developing kinase inhibitors, a hot topic in cancer therapeutics. Researchers frequently search for "pyrimidine-based drug synthesis" and "chloropyrimidine reactivity," reflecting the compound's importance in addressing current healthcare challenges. The hydrochloride salt form enhances solubility, a property highly valued in pharmaceutical formulations.

From a chemical perspective, 77722-80-6 exhibits remarkable stability under standard conditions, with a melting point range of 210-215°C. Its reactivity at the 2-position chlorine atom enables selective substitutions, a feature exploited in parallel synthesis workflows. The compound's structure-activity relationships (SAR) are frequently studied, particularly in designing small molecule therapeutics targeting protein-protein interactions. These characteristics align with current trends in precision medicine and personalized drug development.

Industrial applications of 2-Chloropyrimidine hydrochloride extend beyond pharmaceuticals. The compound serves as a precursor in electronic materials manufacturing, particularly for organic semiconductors used in flexible displays. This connection to green technology solutions addresses the rising interest in "eco-friendly chemical processes" and "bio-based materials." Manufacturers emphasize the compound's role in developing energy-efficient materials, responding to global sustainability initiatives.

Quality control standards for CAS 77722-80-6 require rigorous analytical verification, typically through HPLC purity analysis (>98%) and spectroscopic characterization. The scientific community actively discusses "pyrimidine scaffold optimization" techniques, with particular focus on improving yield and selectivity in multi-step syntheses. These discussions frequently appear in medicinal chemistry forums and process chemistry publications, demonstrating the compound's ongoing relevance in research.

Emerging applications in bioconjugation chemistry have further expanded the utility of 2-Chloropyrimidine HCl. Its ability to form stable linkages with biomolecules supports advancements in diagnostic probe development and targeted drug delivery systems. These applications resonate with current searches for "next-generation biotherapeutics" and "smart drug formulations," positioning the compound at the forefront of biopharmaceutical innovation.

The global market for chloropyrimidine derivatives shows consistent growth, driven by increased R&D investment in orphan drug development and rare disease treatments. Supply chain specialists monitor "high-purity pyrimidine availability" and "GMP-grade intermediates" as critical procurement factors. Regulatory compliance remains paramount, with manufacturers adhering to ICH guidelines and REACH regulations to ensure product consistency and safety.

Recent patent analyses reveal novel applications of 77722-80-6 in photodynamic therapy agents and molecular imaging contrast media. These developments connect to trending searches about "non-invasive diagnostics" and "theranostic platforms." The compound's adaptability across multiple scientific disciplines underscores its importance in contemporary research landscapes, from academic laboratories to industrial-scale production facilities.

Storage and handling recommendations for 2-Chloropyrimidine hydrochloride emphasize protection from moisture and light, typically suggesting airtight containers with desiccants. These protocols align with best practices for sensitive reagents management, a frequent topic in laboratory safety training programs. The compound's stability profile makes it suitable for international shipping, supporting global collaboration in drug discovery projects.

Future research directions likely involve exploring continuous flow chemistry approaches for 2-Chloropyrimidine synthesis, addressing industry demands for process intensification. The compound's role in developing AI-designed pharmaceuticals also presents exciting possibilities, merging traditional chemistry with computational drug design methodologies. These forward-looking applications ensure CAS 77722-80-6 will remain a compound of significant scientific and commercial interest.

• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)