Cas no 77-09-8 (Phenolphthalein)

Phenolphthalein is a widely used pH indicator in analytical chemistry, exhibiting a clear color transition from colorless to pink in the pH range of 8.2 to 10.0. Its high sensitivity and sharp endpoint make it a reliable choice for acid-base titrations, particularly in weak acid-strong base reactions. The compound is also employed in educational laboratories due to its stability and ease of use. Additionally, phenolphthalein has applications in medical diagnostics and as a component in some laxatives, though its use in pharmaceuticals has declined due to safety concerns. Its well-defined chemical properties and versatility in both industrial and academic settings underscore its utility as a standard indicator.
Phenolphthalein structure
Phenolphthalein structure
Product Name:Phenolphthalein
CAS No:77-09-8
MF:C20H14O4
MW:318.322765827179
MDL:MFCD00005913
CID:34067
PubChem ID:24861366
Update Time:2026-05-14

Phenolphthalein Chemical and Physical Properties

Names and Identifiers

    • 3,3-Bis(4-hydroxyphenyl)isobenzofuran-1(3H)-one
    • Phenolphthalein solution
    • 3,3-bis(p-hydroxyphenyl)phthalide
    • ,3-bis(4-hydroxyphenyl)-1(3H)-isobenzofuranore
    • 3,3-bis(4-hydroxyphenyl)-2-benzofuran-1(3H)-one
    • 2-[bis(4-hydroxyphenyl)methyl]benzoic acid
    • 3,3-Bis(4-hydroxyphenyl)-1,3-dihydro-2-benzofuran-1-one
    • C20H14O4
    • Phenolphthalein
    • PHENOLPHTHALEIN, INDICATOR ACS PH 8.2-9.8
    • 3,3-bis(4-hydroxyphenyl)-2-benzofuran-1-one
    • Indicator
    • 3,3-Bis(4-hydroxyphenyl)-1(3H)-isobenzofuranone
    • 3,3-Bis(4-hydroxyphenyl)phthalide
    • Phthalimetten
    • Euchessina
    • Phthalin
    • Phenolax
    • Purgophen
    • Espotabs
    • Trilax
    • Laxogen
    • Koprol
    • Purga
    • Lilo
    • Spulmako-lax
    • Feen-A-Mint Gum
    • Chocolax
    • Purgen
    • Ex-Lax
    • Fenolftalein
    • Correctol
    • Medilax
    • Doxidan
    • Alophen
    • Colax
    • Laxin
    • FemiLax
    • Dihydroxyphthalophenone
    • Phillips Gelcaps
    • Lax-Pills
    • Evac-Q-Tabs
    • Evac-Q-Kwik
    • Evac-U-Gen
    • Evac-Q-Kit
    • 1(3H)-Isobenzofuranone, 3,3-bis(4-hydroxyphenyl)-
    • Phenolphtaleine
    • Fenolftaleina
    • Phe
    • Phenolphthalein pH indicator solution
    • MDL: MFCD00005913
    • Inchi: 1S/C20H14O4/c21-15-9-5-13(6-10-15)20(14-7-11-16(22)12-8-14)18-4-2-1-3-17(18)19(23)24-20/h1-12,21-22H
    • InChI Key: KJFMBFZCATUALV-UHFFFAOYSA-N
    • SMILES: O1C(C2=C([H])C([H])=C([H])C([H])=C2C1(C1C([H])=C([H])C(=C([H])C=1[H])O[H])C1C([H])=C([H])C(=C([H])C=1[H])O[H])=O
    • BRN: 284423

Computed Properties

  • Exact Mass: 318.08900
  • Monoisotopic Mass: 318.089209
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 2
  • Hydrogen Bond Acceptor Count: 4
  • Heavy Atom Count: 24
  • Rotatable Bond Count: 2
  • Complexity: 438
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: 3.6
  • Topological Polar Surface Area: 66.8
  • Surface Charge: 0
  • Tautomer Count: 3

Experimental Properties

  • Color/Form: Colorless or yellowish crystals
  • Density: 0.918?g/mL?at 25?°C
  • Melting Point: 261-263?°C (lit.)
  • Boiling Point: 417.49°C (rough estimate)
  • Flash Point: Fahrenheit: 75.2 ° f
    Celsius: 24 ° c
  • Refractive Index: 1.5400 (estimate)
  • Solubility: Soluble in alcohol. Slightly soluble in ether. Slightly soluble in dimethyl sulfoxide and insoluble in benzene or hexane.
  • Water Partition Coefficient: <0.1 g/100 mL
  • Stability/Shelf Life: Stable. Incompatible with strong oxidizing agents, alkalies.
  • PSA: 66.76000
  • LogP: 3.56010
  • Merck: 7243
  • pka: 9.4(at 25℃)
  • λmax: 552nm, 553nm, 374nm, 205nm, 229nm, 276nm
  • PH: 8.0(colorless)-10(Red)
  • Color/Form: 0.5?wt. % in ethanol: water (1:1)
  • Solubility: Soluble in ethanol and alkali solution, slightly soluble in ether, 1g soluble in 12ml ethanol, about 100ml ether, very slightly soluble in chloroform, insoluble in water
  • Sensitiveness: Sensitive to humidity

Phenolphthalein Security Information

  • Symbol: GHS02 GHS08
  • Prompt:dangerous
  • Signal Word:Danger
  • Hazard Statement: H226,H341,H350
  • Warning Statement: P201,P281,P308+P313
  • Hazardous Material transportation number:UN 1993
  • WGK Germany:3
  • Hazard Category Code: 45-62-68
  • Safety Instruction: S45-S36/37-S33-S24-S16-S7
  • RTECS:SM8380000
  • Hazardous Material Identification: Xn
  • HazardClass:3
  • PackingGroup:II
  • TSCA:Yes
  • Storage Condition:4°C, protect from light
  • Safety Term:S36/37;S45
  • Risk Phrases:R22; R40

Phenolphthalein Customs Data

  • HS CODE:29322910
  • Customs Data:

    China Customs Code:

    29322910

Phenolphthalein Pricemore >>

Related Categories No. Product Name Cas No. Purity Specification Price update time Inquiry
XI GE MA AO DE LI QI ( SHANG HAI ) MAO YI Co., Ltd.
1072330025
Phenolphthalein
77-09-8 indicator ACS,Reag. Ph Eur
25G
707.73 2021-05-17
XI GE MA AO DE LI QI ( SHANG HAI ) MAO YI Co., Ltd.
1072330100
Phenolphthalein
77-09-8 indicator ACS,Reag. Ph Eur
100G
737.77 2021-05-17
XI GE MA AO DE LI QI ( SHANG HAI ) MAO YI Co., Ltd.
1072330500
Phenolphthalein
77-09-8 indicator ACS,Reag. Ph Eur
500G
2711.74 2021-05-17
TRC
P318010-5g
Phenolphthalein
77-09-8
5g
$ 164.00 2023-09-06
TRC
P318010-25g
Phenolphthalein
77-09-8
25g
$ 178.00 2023-09-06
TRC
P318011-50ml
Phenolphthalein (0.04% Solution in Ethanol)
77-09-8
50ml
$ 58.00 2023-09-06
TRC
P318010-250g
Phenolphthalein
77-09-8
250g
$ 230.00 2023-09-06
TRC
P318011-100ml
Phenolphthalein (0.04% Solution in Ethanol)
77-09-8
100ml
$ 63.00 2023-09-06
abcr
AB208414-500 ml
Phenolphthalein, 0.5% w/v in alcohol; .
77-09-8 0.5%
500ml
€86.10 2022-06-11
abcr
AB208414-1 l
Phenolphthalein, 0.5% w/v in alcohol; .
77-09-8 0.5%
1l
€122.80 2022-06-11

Phenolphthalein Production Method

Production Method 1

Reaction Conditions
1.1 Catalysts: 12-Tungstophosphoric acid ;  3 h, 423 K
Reference
MCM-41 Supported Phosphotungstic Acid for the Hydroxyalkylation of Phenol to Phenolphthalein
Jha, Ajay; et al, Industrial & Engineering Chemistry Research, 2012, 51(10), 3916-3922

Phenolphthalein Preparation Products

Phenolphthalein Suppliers

Suzhou Senfeida Chemical Co., Ltd
Gold Member
Audited Supplier Audited Supplier
(CAS:77-09-8)Phenolphthalein
Order Number:sfd8994
Stock Status:in Stock
Quantity:200kg
Purity:99.9%
Pricing Information Last Updated:Friday, 19 July 2024 14:35
Price ($):discuss personally
Tiancheng Chemical (Jiangsu) Co., Ltd
Gold Member
Audited Supplier Audited Supplier
(CAS:77-09-8)Phenolphthalein
Order Number:LE18479;LE2929093;LE4204
Stock Status:in Stock
Quantity:25KG,200KG,1000KG
Purity:99%
Pricing Information Last Updated:Friday, 20 June 2025 12:19
Price ($):discuss personally

Phenolphthalein Spectrogram

13C NMR
13C NMR
1H NMR JEOL DMSO-d6
1H NMR

Additional information on Phenolphthalein

Phenolphthalein (CAS No. 77-09-8): A Comprehensive Overview

Phenolphthalein (CAS No. 77-09-8) is a widely used organic compound with a rich history in both laboratory and industrial applications. This compound, known for its distinctive properties, has found extensive use as a pH indicator and in various analytical procedures. In this comprehensive overview, we will delve into the chemical structure, physical properties, applications, and recent research developments of Phenolphthalein.

Chemical Structure and Physical Properties

Phenolphthalein is a white to slightly yellow, crystalline solid with the molecular formula C20H14O4. It has a molar mass of 318.33 g/mol and is insoluble in water but soluble in organic solvents such as ethanol and acetone. The compound is characterized by its ability to change color in response to pH changes, making it an invaluable tool in acid-base titrations.

In its neutral form, Phenolphthalein is colorless. When the pH of the solution exceeds 8.2, it turns a vivid pink or magenta color due to the formation of its doubly ionized form. This color change is reversible and highly sensitive, allowing for precise determination of pH levels. The mechanism behind this color change involves the deprotonation of the phenolic hydroxyl groups in the molecule.

Applications in Analytical Chemistry

Phenolphthalein is primarily used as a pH indicator in various analytical procedures. Its sensitivity to pH changes makes it particularly useful in acid-base titrations, where it helps determine the endpoint of the reaction. The compound is also employed in educational settings to teach students about acid-base chemistry and pH measurement techniques.

Beyond its use as a pH indicator, Phenolphthalein has found applications in other areas of analytical chemistry. For instance, it can be used as a reagent in complexometric titrations to detect metal ions such as calcium and magnesium. Additionally, it has been utilized in the development of colorimetric sensors for environmental monitoring and industrial process control.

Recent Research Developments

The versatility of Phenolphthalein has led to ongoing research exploring new applications and properties. Recent studies have focused on enhancing its sensitivity and selectivity for specific analytes. For example, researchers have developed modified forms of Phenolphthalein that exhibit enhanced color changes at different pH levels or respond to specific chemical species.

In one notable study published in the Journal of Analytical Chemistry, scientists developed a novel derivative of Phenolphthalein that can detect trace amounts of heavy metals in water samples with high accuracy and sensitivity. This derivative was synthesized by attaching functional groups that specifically bind to metal ions, thereby enhancing its selectivity and detection capabilities.

Safety Considerations and Environmental Impact

Phenolphthalein is generally considered safe for laboratory use when proper handling protocols are followed, it is important to note that prolonged exposure or improper disposal can pose environmental risks. Studies have shown that high concentrations of Phenolphthalein can have adverse effects on aquatic life if released into water bodies without proper treatment.

To mitigate these risks, it is crucial to follow recommended safety guidelines for handling and disposing of Phenolphthalein. Proper waste management practices, such as neutralization before disposal or recycling through specialized facilities, can help minimize environmental impact.

FUTURE DIRECTIONS AND CONCLUSIONS

The future of Phenolphthalein-based research looks promising, with ongoing efforts aimed at developing more advanced derivatives and applications. As analytical techniques continue to evolve, the role of compounds like Phenolphthalein strong > will remain crucial in ensuring accurate and reliable measurements.

In conclusion, Phenolphthalein strong > (CAS No. 77-09-8) stands out as a versatile and essential compound in the field of analytical chemistry. Its unique properties make it an indispensable tool for pH measurement and other analytical procedures. With continued research and innovation, we can expect even more exciting developments in the use of this remarkable compound. p > article > < /response >

Recommended suppliers
Suzhou Senfeida Chemical Co., Ltd
(CAS:77-09-8)Phenolphthalein
sfd8994
Purity:99.9%
Quantity:200kg
Price ($):Inquiry
Email
Tiancheng Chemical (Jiangsu) Co., Ltd
(CAS:77-09-8)Phenolphthalein
LE18479;LE2929093;LE4204
Purity:99%/99%/99%
Quantity:25KG,200KG,1000KG/25KG,200KG,1000KG/25KG,200KG,1000KG
Price ($):Inquiry/Inquiry/Inquiry
Email