• 1. An aptamer-based keypad lock system?
  Yaqing Liu,Jiangtao Ren,Jing Li,Jiyang Liu,Erkang Wang Chem. Commun., 2012,48, 802-804
• 2. An anti-ultrasonic-stripping effect in confined micro/nanoscale cavities and its applications for efficient multiscale metallic patterning?
  Quan Xiang,Yiqin Chen,Zhiqin Li,Kaixi Bi,Guanhua Zhang,Huigao Duan Nanoscale, 2016,8, 19541-19550
• 3. An air-stable organometallic polymer containing titanafluorene moieties obtained by the Sonogashira–Hagihara cross-coupling polycondensation?
  Alvin Tanudjaja,Shinsuke Inagi,Fusao Kitamura,Toshikazu Takata,Ikuyoshi Tomita Dalton Trans., 2021,50, 3037-3043
• 4. An investigation of surface properties, local elastic modulus and interaction with simulated pulmonary surfactant of surface modified inhalable voriconazole dry powders using atomic force microscopy
  Michael Kappl,Paul M. Young,Daniela Traini,Sanyog Jain RSC Adv., 2016,6, 25789-25798
• 5. Alternative donor substrates for inverting and retaining glycosyltransferases?
  Luke L. Lairson,Warren W. Wakarchuk Chem. Commun., 2007, 365-367

Comprehensive Overview of 4-(4-Chlorophenyl)-2-fluorobenzoic acid (CAS 764722-93-2): Properties, Applications, and Research Insights

4-(4-Chlorophenyl)-2-fluorobenzoic acid (CAS 764722-93-2) is a fluorinated aromatic carboxylic acid derivative with significant relevance in pharmaceutical and agrochemical research. This compound, characterized by its chlorophenyl and fluorobenzoic acid moieties, has garnered attention due to its versatile applications in drug discovery and material science. Its molecular structure, combining halogenated aromatic rings, makes it a valuable intermediate for synthesizing bioactive molecules targeting inflammation, metabolic disorders, and other therapeutic areas.

In recent years, the demand for fluorinated organic compounds like 4-(4-Chlorophenyl)-2-fluorobenzoic acid has surged, driven by their enhanced metabolic stability and bioavailability. Researchers frequently explore its potential in structure-activity relationship (SAR) studies, particularly in designing kinase inhibitors or GPCR modulators. The compound's CAS number 764722-93-2 is often searched in academic databases, reflecting its growing role in medicinal chemistry.

From a synthetic perspective, 4-(4-Chlorophenyl)-2-fluorobenzoic acid is synthesized via palladium-catalyzed cross-coupling reactions or halogen-exchange methodologies. Its fluorine substitution at the 2-position of the benzoic acid ring influences electronic properties, making it a candidate for proton-coupled electron transfer (PCET) studies. These attributes align with current trends in green chemistry, where researchers prioritize atom-efficient routes to reduce waste.

The compound's physicochemical properties—such as its logP value, solubility profile, and crystalline structure—are critical for formulation scientists. Analytical techniques like HPLC and NMR spectroscopy are routinely employed to validate its purity, a topic frequently queried in quality control forums. Regulatory guidelines, including ICH Q3D for elemental impurities, further underscore the need for rigorous characterization.

Beyond pharmaceuticals, CAS 764722-93-2 finds niche applications in organic electronics, where its aromatic system contributes to charge transport in thin-film devices. This dual utility in life sciences and materials research positions it as a multidisciplinary building block, a keyword often linked to high-impact publications.

Environmental considerations also shape discussions around 4-(4-Chlorophenyl)-2-fluorobenzoic acid. Its biodegradation pathways and ecotoxicological profile are subjects of ongoing study, reflecting broader societal interest in persistent organic pollutants (POPs). Computational tools like molecular docking and QSAR models help predict its environmental fate, addressing queries from sustainability-focused researchers.

In summary, 4-(4-Chlorophenyl)-2-fluorobenzoic acid (CAS 764722-93-2) exemplifies the convergence of synthetic innovation and applied science. Its halogenated architecture and carboxylic acid functionality offer a robust platform for diverse scientific inquiries, making it a staple in modern chemical research.

• 1179618-11-1(5-(4-Chlorophenyl)-2-fluorobenzoic Acid)
• 1261913-97-6(4-(3,5-Dichlorophenyl)-2-fluorobenzoic acid)
• 1261892-24-3(2-(4-Chloro-2-methylphenyl)-6-fluorobenzoic acid)
• 926235-03-2(4-(3,4-Dichlorophenyl)-2-fluorobenzoic acid)
• 1261933-47-4(5-(3-Chlorophenyl)-2-fluorobenzoic acid)
• 926201-40-3(5-(3,4-Dichlorophenyl)-2-fluorobenzoic acid)
• 1261904-48-6(4-(4-chlorophenyl)-3-fluorobenzoic acid)
• 1261901-81-8(4-(4-Chloro-2-methylphenyl)-2-fluorobenzoic acid)
• 1261929-04-7(4-(3-Chlorophenyl)-2-fluorobenzoic acid)
• 1261901-57-8(4-(3-Chloro-4-methylphenyl)-2-fluorobenzoic acid)