• 1. Exchangeability of amino acid residues with similar physicochemical properties in coiled-coil interactions?
  Guiying Zhang,Maosheng Cheng,Yanni Li,Keliang Liu,Lifeng Cai Chem. Commun., 2013,49, 11086-11088
• 2. Distributed research: a new paradigm for undergraduate research and global problem solving?
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• 3. Enantiopure 2,6-disubstituted piperidines bearing one alkene- or alkyne-containing substituent: preparation and application to total syntheses of indolizidine-alkaloids?
  Hui Liu,Deyong Su,Guolin Cheng,Jimin Xu,Xinyan Wang,Yuefei Hu Org. Biomol. Chem., 2010,8, 1899-1904
• 4. Fe3O4 nanoparticle chains with N-doped carbon coating: magnetotactic bacteria assisted synthesis and high-rate lithium storage?
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• 5. Enantio- & chemo-selective preparation of enantiomerically enriched aliphatic nitro alcohols using Candida parapsilosis ATCC 7330
  Sowmyalakshmi Venkataraman RSC Adv., 2015,5, 73807-73813

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Chlorobenzenes
• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Halobenzenes Chlorobenzenes

Comprehensive Analysis of (R)-1-(4-Chlorophenyl)ethanol (CAS No. 75968-40-0): Properties, Applications, and Industry Insights

(R)-1-(4-Chlorophenyl)ethanol (CAS No. 75968-40-0) is a chiral aromatic alcohol with significant relevance in pharmaceutical synthesis and fine chemical industries. This optically active compound, characterized by its 4-chlorophenyl group and hydroxyl functionality, serves as a versatile intermediate in asymmetric catalysis and enantioselective reactions. The growing demand for chiral building blocks in drug development has propelled interest in this molecule, particularly for applications in steroselective synthesis and API manufacturing.

Recent studies highlight the compound's role in developing non-racemic pharmaceuticals, aligning with the pharmaceutical industry's focus on enantiomerically pure drugs. Its CAS registry number 75968-40-0 is frequently searched in chemical databases, reflecting its importance in organocatalysis and chiral resolution processes. The (R)-configuration of this ethanol derivative offers distinct advantages in constructing complex molecular architectures, making it valuable for asymmetric hydrogenation research.

From a molecular perspective, (R)-1-(4-Chlorophenyl)ethanol exhibits unique physicochemical properties. The chlorophenyl moiety enhances lipophilicity, while the hydroxyl group enables hydrogen bonding - characteristics that influence its solubility profile and reactivity patterns. These attributes are particularly relevant for researchers investigating structure-activity relationships in medicinal chemistry. Analytical techniques like chiral HPLC and polarimetry are commonly employed to verify its enantiomeric purity, a critical quality parameter for pharmaceutical applications.

The synthesis of CAS 75968-40-0 typically involves biocatalytic reduction or transition metal-catalyzed asymmetric hydrogenation of corresponding ketones. Current industry trends emphasize green chemistry approaches, with particular interest in enzymatic kinetic resolution methods that offer higher atom economy and reduced environmental impact. These sustainable production methods address growing concerns about green synthesis in fine chemical manufacturing, a topic frequently queried in scientific literature searches.

In material science applications, (R)-1-(4-Chlorophenyl)ethanol demonstrates potential as a precursor for liquid crystal materials and chiral dopants. Its molecular structure allows for the introduction of various functional groups, enabling the creation of novel optically active polymers. This versatility explains why searches for "chiral alcohol applications" and "asymmetric synthesis intermediates" consistently include references to this compound in academic and industrial research.

Quality control of 75968-40-0 requires stringent analytical protocols. Modern characterization techniques such as NMR spectroscopy, mass spectrometry, and X-ray crystallography provide comprehensive structural verification. The compound's storage stability and handling requirements are common concerns among researchers, with optimal conditions typically involving inert atmospheres and temperature-controlled environments to preserve its enantiomeric excess.

Emerging research explores the compound's potential in catalytic asymmetric transformations, particularly in constructing chiral tertiary alcohols - a structural motif prevalent in bioactive molecules. This aligns with current pharmaceutical industry priorities for developing next-generation therapeutics with improved efficacy and reduced side effects. The compound's molecular descriptor features make it particularly valuable for computer-aided drug design (CADD) applications, a rapidly growing field in pharmaceutical R&D.

Regulatory aspects of (R)-1-(4-Chlorophenyl)ethanol production emphasize compliance with ICH guidelines for pharmaceutical intermediates. Documentation of genotoxic impurities and residual solvents represents a critical component of quality assurance protocols. These considerations reflect the compound's importance in GMP-compliant synthesis workflows, particularly for applications in clinical-stage pharmaceuticals.

The global market for chiral intermediates like CAS 75968-40-0 continues to expand, driven by increasing demand for single-enantiomer drugs. Market analysis indicates particular growth in Asia-Pacific regions, where contract research organizations and custom synthesis providers are scaling up production capabilities. This geographic trend corresponds with search engine data showing rising queries for "chiral chemical suppliers" and "pharmaceutical intermediates sourcing" in these emerging markets.

Future research directions for (R)-1-(4-Chlorophenyl)ethanol may explore its utility in continuous flow chemistry systems and photocatalytic transformations - two areas gaining traction in process chemistry optimization. The compound's structural features make it an interesting candidate for developing novel chiral ligands and organocatalysts, potentially enabling more efficient routes to complex active pharmaceutical ingredients (APIs).

• 6939-95-3(1-(3-Chlorophenyl)ethanol)
• 3391-10-4(1-(4-Chlorophenyl)ethanol)
• 75968-35-3(1-(4-chlorophenyl)ethanol)
• 152142-03-5((1R)-1-(4-chlorophenyl)-1,2-ethanediol)
• 99528-42-4((S)\u200b-\u200b1-\u200b(4-\u200bChlorophenyl)\u200bethanol)
• 119-56-2(4-Chlorobenzhydrol)
• 90-97-1(4,4'-Dichlorobenzhydrol)
• 7477-64-7(1-(4-Chlorophenyl)ethane-1,2-diol)
• 123535-85-3(Benzenemethanol, 4-chloro-a-phenyl-, (aR)-)
• 1475-11-2(1-(3,4-Dichlorophenyl)ethanol)