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  Yu-Nong Li,Liang-Nian He,Xian-Dong Lang,Xiao-Fang Liu,Shuai Zhang RSC Adv., 2014,4, 49995-50002
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  Kaiyuan Huang,Wangkang Qiu,Meilian Ou,Xiaorui Liu,Zenan Liao,Sheng Chu RSC Adv., 2020,10, 18824-18829
• 3. An anti-ultrasonic-stripping effect in confined micro/nanoscale cavities and its applications for efficient multiscale metallic patterning?
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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Quinolines and derivatives Aminoquinolines and derivatives

Introduction to 8-Chloroquinolin-5-amine (CAS No. 75793-58-7)

8-Chloroquinolin-5-amine, with the CAS number 75793-58-7, is a compound that has garnered significant attention in the field of medicinal chemistry due to its unique structural properties and potential biological activities. This compound belongs to the class of quinolines, which are known for their diverse pharmacological effects, including antimalarial, antibacterial, and antiviral activities.

The chemical structure of 8-chloroquinolin-5-amine consists of a quinoline ring with a chlorine atom at the 8-position and an amino group at the 5-position. This specific arrangement of functional groups imparts distinct chemical and biological properties to the molecule. The presence of the chlorine atom enhances the lipophilicity of the compound, which can influence its bioavailability and cellular uptake. The amino group, on the other hand, provides opportunities for further functionalization and derivatization, making it a valuable starting material for drug discovery and development.

Recent research has focused on exploring the potential therapeutic applications of 8-chloroquinolin-5-amine. One notable area of interest is its antimalarial activity. Malaria remains a significant global health challenge, and the development of new antimalarial drugs is crucial to combat drug-resistant strains of the parasite. Studies have shown that 8-chloroquinolin-5-amine exhibits potent activity against Plasmodium falciparum, one of the most virulent species causing malaria. The mechanism of action involves disruption of parasite metabolism and inhibition of key enzymes involved in DNA replication and repair.

In addition to its antimalarial properties, 8-chloroquinolin-5-amine has also been investigated for its antibacterial and antiviral activities. Preliminary studies have demonstrated that this compound can inhibit the growth of various bacterial strains, including Gram-positive and Gram-negative bacteria. Its antiviral potential has been explored in vitro against several viruses, such as influenza and herpes simplex virus (HSV). The broad-spectrum activity of 8-chloroquinolin-5-amine makes it a promising candidate for further development as a multifunctional therapeutic agent.

The pharmacokinetic properties of 8-chloroquinolin-5-amine have also been studied to understand its behavior in biological systems. Research indicates that it has good oral bioavailability and a favorable pharmacokinetic profile, which are essential characteristics for a drug candidate. However, further studies are needed to optimize its pharmacokinetic parameters and enhance its therapeutic efficacy.

Safety and toxicity assessments are crucial steps in the drug development process. Preclinical studies have shown that 8-chloroquinolin-5-amine exhibits low toxicity at therapeutic concentrations. However, as with any new compound, comprehensive safety evaluations are required to ensure its long-term safety in humans. These assessments include in vitro cytotoxicity tests, animal toxicity studies, and genotoxicity evaluations.

The synthetic routes for preparing 8-chloroquinolin-5-amine have been well-documented in the literature. Common methods involve multi-step reactions starting from readily available precursors such as 2-aminoanthraquinone or 2-aminoacridine. These synthetic pathways provide flexibility in modifying the structure to enhance specific biological activities or improve pharmacological properties.

In conclusion, 8-chloroquinolin-5-amine (CAS No. 75793-58-7) is a promising compound with diverse biological activities and potential therapeutic applications. Its unique chemical structure and favorable pharmacokinetic properties make it an attractive candidate for further research and development in medicinal chemistry. Ongoing studies aim to elucidate its mechanisms of action, optimize its pharmacological profile, and evaluate its safety for clinical use.

• 948293-25-2(4-Amino-7,8-dichloroquinoline)
• 314272-29-2(7,8-Dichloroquinolin-5-amine)
• 114306-29-5(4-Quinolinamine,6-chloro-, hydrochloride (1:1))
• 103028-96-2(3-Chloroquinolin-6-amine)
• 20028-60-8(6-Chloroquinolin-4-amine)
• 65340-72-9(8-Chloroquinolin-4-amine)
• 23250-39-7(9-Acridinamine,2-chloro-)
• 23250-40-0(9-Acridinamine,4-chloro-)
• 61981-67-7(9-Acridinamine, 4-chloro-N-methyl-)
• 61260-22-8(3-Chloroquinolin-4-amine)